Molecular switch for WNT5A/B expression through TCF-4 isoforms in human liver cancer cells

人肝癌细胞中通过 TCF-4 亚型实现 WNT5A/B 表达的分子开关

• 批准号: 26461025
• 负责人: Koga Hironori
• 金额: $ 3.16万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461025/
• 关键词: Wntシグナル; T-cell factor-4; 癌幹細胞; TCF-4; Wnt; isoform; Hes1; Notch

项目成果

幹細胞未分化状態維持因子Hes1はNotchおよびWntからのdual regulationを受ける

干细胞未分化状态维持因子Hes1接受Notch和Wnt双重调控

• 发表时间: 2016
• 作者: Iwamoto H;Nakamura T;Koga H;Izaguirre-Carbonell J;Kamisuki S;Sugawara F;Abe M;Iwabata K;Ikezono Y;Sakaue T;Masuda A;Yano H;Ohta K;Nakano M;Shimose S;Shirono T;Torimura T.;古賀浩徳，矢野博久，鳥村拓司
• 通讯作者: 古賀浩徳，矢野博久，鳥村拓司

Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK1

• DOI: 10.1158/1541-7786.mcr-16-0285
• 发表时间: 2017-06-01
• 期刊: MOLECULAR CANCER RESEARCH
• 影响因子: 5.2
• 作者: Ikezono, Yu;Koga, Hironori;Torimura, Takuji
• 通讯作者: Torimura, Takuji

Expression of HES1, a Notch regulator of biliary features, is regulated by T-cell factor-4 isoforms

HES1（胆道特征的 Notch 调节因子）的表达受 T 细胞因子 4 亚型调节

• 发表时间: 2015
• 作者: Koga H;Yano H;Torimura T
• 通讯作者: Torimura T

Antiangiogenic and Antitumor Activities of Aflibercept, a Soluble VEGF Receptor-1 and -2, in a Mouse Model of Hepatocellular Carcinoma.

• DOI: 10.1016/j.neo.2016.05.001
• 发表时间: 2016-07
• 期刊: Neoplasia (New York, N.Y.)
• 作者: Torimura T;Iwamoto H;Nakamura T;Abe M;Ikezono Y;Wada F;Sakaue T;Masuda H;Hashimoto O;Koga H;Ueno T;Yano H
• 通讯作者: Yano H

Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces "angiogenic switch off" in a hepatoma mouse model.

• DOI: 10.1038/mto.2015.20
• 发表时间: 2015
• 期刊: Molecular therapy oncolytics
• 作者: Iwamoto H;Nakamura T;Koga H;Izaguirre-Carbonell J;Kamisuki S;Sugawara F;Abe M;Iwabata K;Ikezono Y;Sakaue T;Masuda A;Yano H;Ohta K;Nakano M;Shimose S;Shirono T;Torimura T
• 通讯作者: Torimura T