Mechanisms, functions and evoution of Wnt-signaling pathways

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The DFG funds since December 2008 the research group (Forschergruppe) which focuses on the analysis of the Wnt-signaling network. This regulator module is essential for embryonic development and is responsible for a number of human diseases. The signaling event triggered by Wnt-type growth factors are competitive research filed with high relevance for biological and medical research. 8 groups which work on different aspects of Wnt-signaling joined the Forschergruppe. The participating groups are affiliated with the University Heidelberg (T. Holstein, Zoology; S. Özbek, Zoology; S. Hardt, Cardiologie; H. Steinbeisser, Human Genetics), the University Karlsruhe (D. Wedlich, Zoology; D. Gradl, Zoology) und with the German Cancer Research Center (DKFZ) Heidelberg (M. Boutros; C. Niehrs). The Forschergruppe addresses the following questions:- How are Wnt-proteins modified, secreted and - how do they form activity gradients?- How do components of the Wnt-signaling cascade interact inside and outside the cell?- What are the roles of Wnt-signaling molecules in organ formation and remodeling?The group uses a structure function approach which requires an arsenal of techniques from biochemistry, structural biology, cell biology and physiology. The members contribute a very complementary set of expertise and experimental models. In this context the animal /embryo models (Hydra/Nematostella; Drosophila, Xenopus und mouse) used by members of the Forschergruppe are of particular importance.