Measurement of trace elements with micro-PIXE method in myeloma cells and development of novel drugs

Micro-PIXE法测定骨髓瘤细胞中微量元素及新药开发

• 批准号: 26460720
• 负责人: Murakami Hirokazu
• 金额: $ 3.16万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460720/
• 关键词: 多発性骨髄腫; マイクロPIXE; 微量元素; ボルテゾミブ; bortezomib

项目成果

Post-marketing surveillance of the treatment with THALEDR CAPSULE in patients with relapsed/refractory multiple myeloma.

THALEDR 胶囊治疗复发/难治性多发性骨髓瘤患者的上市后监测。

• 发表时间: 2015
• 期刊: International Journal of Myeloma
• 作者: Hirokazu Murakami;Kazuyuki Shimizu and Toshiyuki Takagi.
• 通讯作者: Kazuyuki Shimizu and Toshiyuki Takagi.

Loop Regulation Between microRNAs and Epigenetics Underlie microRNA Dysregulation in Multiple Myeloma and Is Associated with the Disease Progression

microRNA 和表观遗传学之间的环路调节是多发性骨髓瘤中 microRNA 失调的基础，并与疾病进展相关

• 发表时间: 2015
• 作者: Kei Kimura;et al.
• 通讯作者: et al.

Prognostic Impact of Cytogenetic Abnormalities in Adult Patients with Philadelphia-Chromosome(Ph)-Negative Acute Lymphoblastic Leulemia(ALL) Who Underwent Allogeneic Stem Cell Transplant(allo-SCT)

细胞遗传学异常对接受同种异体干细胞移植（allo-SCT）的费城染色体（Ph）阴性急性淋巴细胞白血病（ALL）成年患者的预后影响

• 发表时间: 2015
• 作者: Hiroaki Shimizu;et al.
• 通讯作者: et al.

High expression level and D148E polymorphism of APE1 are associated with acute myeloid leukemia

APE1高表达及D148E多态性与急性髓系白血病相关

• 发表时间: 2015
• 作者: Nanami Gotoh;et al.
• 通讯作者: et al.

Methylation and Hydroxymethylation Status of Tumor Suppressor Genes and Common Fragile Sites Genes in Acute Myeloid Leukemia

急性髓系白血病抑癌基因和常见脆弱位点基因的甲基化和羟甲基化状态

• 发表时间: 2014
• 作者: Suda I;Handa H;Kaneko A;Masuda Y;Kimura K;Kuroda Y;Kasamatsu T;Minato Y;Tahara K;Shimizu H;Ishizaki T;Mitsui T;Yokohama A;Koiso H;Takizawa M;Saitoh T;Hatsumi N;Takada S;Sakura T;Tsukamoto N;Nojima Y;Murakami H
• 通讯作者: Murakami H