Chemical Studies on Bioluminescent Material and Natural Product in Tropical Area

在天然生物活性物质化学领域，新结构和重要的海洋生物化合物的研究取得了显著进展。本项目旨在热带地区新的发光生物中寻找新的发光系统。它还包括在这些热带地区强烈活跃的天然产品。H10财政年度，有5名研究人员访问并停留了一个或两个月，继续他们的研究工作，特别是NMR和质谱的分析研究。因此，已经确定了peptaibol、肉毒毒素以及一些环肽的许多序列异质性。在发光方面，发现了各种发光生物，特别是在参加普吉海洋生物中心活动的采样巡航期间。在泰国南部的安达曼海，它们是海笔、裸鳃类、鱿鱼、蠕虫、介形类。利用CCD光谱仪、便携式高效液相色谱仪等对可能的发光体系进行了鉴定，获得了相当多的结果。通过目前的合作研究计划，在名古屋大学和朱拉隆功大学、孔敬大学、King Mong技术研究所、玛希隆大学、宋卡王子大学的天然产物化学家之间建立了新的研究渠道。它在科学上是相当成功的。

In the field of chemistry of naturally occurring bioactive materials there have been remarkable progress of new structures and important compounds from marine organisms. This project aims at searching for a new bioluminescent system in new luminous organisms in tropical area. It also includes strongly active natural products in these tropical area. For comparison, those luminous systems as well as other biologically active materials have been compared with those in Okinawan area.Fiscal year H10, 5 researchers have visited and stayed for one or two months to continue their research work, particularly analytical studies with NMR and Mass Spectroscopy. As a results many sequence heterogeneity of peptaibol, trichotoxin, have been established as well as some cyclic peptides. In respect to the luminescence, various many kinds of luminous organisms have been found, particularly during joining the sampling cruise with the activity of Phuket Marine Biology Center. They are sea pen, nudibranch, squid, worm, ostracod in Andaman Sea, South Thailand. Bringing a CCD spectrometer, a portable HPLC, etc afforded quite productive results for identification of the possible luminous system.New research channel among natural product chemists in Nagoya University and Chulalongkom, Khon Keen, King Mong Institute of Technology, Mahidol, Prince of Songkla Universities have been established through the current cooperative research program. It was quite successful in scientifically.