Chemical Studies on Bioluminescent Material and Natural Product in Tropical Area

在天然生物活性物质化学领域，海洋生物新结构和重要化合物的研究取得了显着进展。本项目的目的是在热带地区新的发光生物中寻找新的生物发光系统。它还包括这些热带地区具有强烈活性的天然产品。为了比较，这些发光系统以及其他生物活性物质已经与冲绳地区的比较。财政年度H10，5研究人员访问并停留了一到两个月，继续他们的研究工作，特别是核磁共振和质谱学的分析研究。因此，已经建立了许多序列异质性的肽，毛霉毒素，以及一些环肽。在发光方面，已经发现了各种各样的发光生物，特别是在参加普吉岛海洋生物中心活动的采样巡航期间。它们是泰国南部安达曼海的海笔、裸目、鱿鱼、蠕虫、介形虫。通过目前的合作研究计划，在名古屋大学和朱拉隆功、坤基恩、蒙王理工学院、玛希多尔、松拉王子大学的天然产品化学家之间建立了新的研究渠道。它在科学上是相当成功的。

In the field of chemistry of naturally occurring bioactive materials there have been remarkable progress of new structures and important compounds from marine organisms. This project aims at searching for a new bioluminescent system in new luminous organisms in tropical area. It also includes strongly active natural products in these tropical area. For comparison, those luminous systems as well as other biologically active materials have been compared with those in Okinawan area.Fiscal year H10, 5 researchers have visited and stayed for one or two months to continue their research work, particularly analytical studies with NMR and Mass Spectroscopy. As a results many sequence heterogeneity of peptaibol, trichotoxin, have been established as well as some cyclic peptides. In respect to the luminescence, various many kinds of luminous organisms have been found, particularly during joining the sampling cruise with the activity of Phuket Marine Biology Center. They are sea pen, nudibranch, squid, worm, ostracod in Andaman Sea, South Thailand. Bringing a CCD spectrometer, a portable HPLC, etc afforded quite productive results for identification of the possible luminous system.New research channel among natural product chemists in Nagoya University and Chulalongkom, Khon Keen, King Mong Institute of Technology, Mahidol, Prince of Songkla Universities have been established through the current cooperative research program. It was quite successful in scientifically.