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Comparative analysis of genetic factor in Buerger disease

布尔格病遗传因素的比较分析

基本信息

批准号：
09041176
负责人：
KOBAYASHI Yasushi
金额：
$ 8.96万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09041176/
关键词：
Buerger's disease Throboangitis Obliterans HLA 血管炎バ-ジャー病閉塞性血栓性血管炎

项目摘要

Buerger's Disease, Thromboangitis obliterans, is known to be a intractable vasculitis maimly involving middle size arteries of lower extremities and also vein. It also involves the aretry of upper arm and visceral arteries. The pathogenesis of Buerger's disease is atill unknown even smoking is known exacerbate this morbid condition.Inthis project, we focused in the genetic factor of Buerger's disease to know its pathogenesis especially on HLA and MIC-A in the patients of Japanese, other Asian countries, Middle East, South Americans.At the biginning, we showed HLA-DR4, 15a and 16 was significantly associated with Buerger's disease in Japanese. The we started registration of Buerger's disease from Japan, India, Thailand, Mexico, Colombia, Turkey, Israel and U.S.A.according the standard criteria of diagnisis of Buerger's disease.And we held two International Conference on Buerger's Disease. 1st conference was held in Karuizawa, Japan from Novemver 4 to 6, 1997 and second congress was in Atlanta, U.S.A.from October 5 to 8,1998.We invited specialists on Buger's disease and discussed on 1) clinical views, 2) pathogenesis, 3) molecular mechanism of thrombogenesis in Buerger's disease, 4) the risk of smoking in Buerger's disease, 5) genetic factor in the pathogenesis of Buerger's disease, 6) adhesion molecules, 7) diagnosis and so on. We also discussed on Talayasu Arteritis , Temporal arteritis, and IAAA as well.Finally we reported our activity of this project in the special issue of lnternational Journal of Cardiology in 1998.

血栓闭塞性脉管炎（Thromboangitisobliterans，Buerger病）是一种顽固性血管炎，主要累及下肢中等大小的动脉和静脉。它还涉及上臂动脉和内脏动脉。Buerger病的发病机制至今仍不清楚，吸烟是其发病的重要因素，本课题主要从遗传因素入手，对日本、亚洲其他国家、中东、南美等地Buerger病患者的HLA和MIC-A进行了研究，初步发现日本人的HLA-DR 4、15 a和16与Buerger病有显著相关性。根据Buerger病的诊断标准，我们从日本、印度、泰国、墨西哥、哥伦比亚、土耳其、以色列和美国等国家开始登记Buerger病，并召开了两次Buerger病国际会议。第一届会议于1997年11月4日至6日在日本轻井泽召开，第二届会议于1998年10月5日至8日在美国亚特兰大召开。我们邀请了Buger病的专家，讨论了1）Buerger病的临床观点，2）发病机制，3）血栓形成的分子机制，4）Buerger病的吸烟风险，本文就Buerger病的发病机制、遗传因素、粘附分子、诊断等方面进行了综述，并对Talayasu动脉炎、颞动脉炎、IAAA等进行了讨论，最后在1998年《国际心脏病杂志》专刊上报道了我们的研究活动。