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Wobble Genomics: Unlocking the world of genes

Wobble Genomics：解锁基因世界

基本信息

批准号：
10000729
负责人：
金额：
$ 37.78万
依托单位：
WOBBLE GENOMICS
依托单位国家：
英国
项目类别：
Study
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=10000729
关键词：
Wobble Genomics Unlocking world genes

项目摘要

Imagine what we could do if we could find every gene. We could breed crops resistant to disease, develop better treatments for cancer, or diagnose illnesses before they become untreatable. Wobble Genomics is working to make this a reality.Genes are the basis of all life. Every cell in your body is constantly expressing genes in the form of RNA. These RNA are signals which provide directions for biological functions. If we could understand these signals, we could decipher the code of life. Our most advanced means of detecting these signals is through a technology called RNA sequencing.While this technology has the potential to revolutionize a wide range of biology, it is currently limited by a basic biological phenomenon. Most of the RNA produced by a cell are common to all cells and are thus uninformative. This means that most of the data we attain through RNA sequencing is essentially noise.Our Level-Up technology solves this problem by making it easier to find important RNA while our TAMA software provides greater insight into gene functions. Finding and understanding these RNA/genes will benefit a wide range of biotechnology including drug development, diagnostics, gene editing, agriculture, and conservation efforts.Wobble Genomics will help usher in the age of RNA and provide a foundation for the next generation of biotechnology.

想象一下，如果我们能找到每一个基因，我们能做什么。我们可以培育抗病作物，开发更好的癌症治疗方法，或者在疾病变得无法治疗之前对其进行诊断。 Wobble Genomics 正在努力使这成为现实。基因是所有生命的基础。你体内的每个细胞都在不断以 RNA 的形式表达基因。这些RNA是为生物功能提供方向的信号。如果我们能够理解这些信号，我们就能破译生命的密码。我们检测这些信号的最先进方法是通过一种称为 RNA 测序的技术。虽然这项技术有可能彻底改变广泛的生物学，但目前它受到基本生物学现象的限制。细胞产生的大部分 RNA 对所有细胞来说都是通用的，因此信息量不大。这意味着我们通过 RNA 测序获得的大部分数据本质上都是噪音。我们的 Level-Up 技术可以更轻松地找到重要的 RNA，同时我们的 TAMA 软件可以更深入地了解基因功能，从而解决了这个问题。寻找和了解这些 RNA/基因将有利于广泛的生物技术，包括药物开发、诊断、基因编辑、农业和保护工作。Wobble Genomics 将帮助迎来 RNA 时代，并为下一代生物技术奠定基础。