High-Value Biorenewable Peptides from Proteinaceous Biomass

贝尔和洛克斯顿创新公司是一家高度创新的循环经济公司，是从南德文郡的一个农场剥离出来的。我们的财团已经认识到了从丰富的农业和食品加工共同流中生产高价值生物可再生材料(HVB)的机会。许多副产物，如榨油过程中产生的油籽预滤饼和酿造酵母和谷物的废渣，蛋白质含量很高，通常被丢弃或在低经济价值的应用中下游使用。来自不同自然来源的蛋白质具有独特的氨基酸组成，无论是在流行程度上还是在它们的序列方面。因此，这些生物可再生蛋白质的蛋白质分解将产生在大小、氨基酸组成和序列上不同的小肽的独特分布。这种多样性使不同的高价值市场部门得以迎合，如营养、个人护理和制药，因为不同的多肽具有不同的生物学特性。从历史上看，定制的多肽一直是以高昂的成本从化学/化石燃料原料中合成的。识别独特的高价值生物可再生蛋白质，然后生产定制的多肽和混合物(水解物)，将使循环经济方法能够为多个行业提供服务，从而对环境产生好处。我们的财团汇集了发展成功和可扩展的绿色化学品业务所必需的部分：贝尔和洛克斯顿创新公司凭借其强大的农业、食品和农业生产经验，生物可再生能源开发中心(BDC)凭借其对废物和同流作价技术的深入知识，和Thomas Swan&Co Ltd作为一家成熟的化学品制造企业，实现扩大生产，同时实现向100%生物可再生饲料转移的使命。我们将从与BDC进行的成功的价态可行性研究中继续这个项目，与我们的市场制造合作伙伴Thomas Swan合作，开发一种可扩展和可申请专利的工艺，以控制所得到的多肽水解物的组成和分子量范围，每种多肽水解物都具有各自独特的生物活性，并针对特定市场。为了在合理的时间框架内实现收入，我们将首先专注于个人护理应用(护肤、护发)，在这些应用中，对这类多肽的高需求已经存在，并受到比例监管。

Bell & Loxton Innovations is a highly innovative, circular-economy spin-out from a working farm in South Devon. Our consortium has recognised an opportunity to produce high-value biorenewable (HVB) materials from abundant agricultural and food-processing co-streams. Many co-streams such as oilseed presscake created during oil extraction and spent brewing yeast and grain are high in protein and are routinely discarded or used downstream in low-economic value applications. Proteins from different natural sources have unique compositions of amino acids both in prevalence and in terms of their sequence. Consequently, proteolysis of these biorenewable proteins will create unique distributions of smaller peptides that differ in size, amino acid compositions and sequence. This diversity enables different high-value market sectors to be catered for such as nutrition, personal care and pharmaceuticals as different peptides have different biological properties.Historically, bespoke peptides have been chemically synthesised at high cost from chemical/fossil fuel feedstocks. Identifying unique high-value biorenewable proteins and then producing tailored peptides and blends (hydrolysates) will enable a circular economy approach to supplying multiple industry sectors with a consequent benefit to the environment.Our consortium brings together the necessary parts for developing a successful and scalable 'green' chemicals business: Bell & Loxton Innovations with its strong farming, food and agricultural production experience, The Biorenewables Development Centre (BDC) with its in-depth knowledge of waste and co-stream valorisation techniques, and Thomas Swan & Co Ltd as an established chemicals manufacturing business to enable scale-up production coupled with a mission to move to 100% biorenewable feedstocks.Continuing this project from a successful valorisation feasibility study conducted with the BDC, we will work with our route to market manufacturing partner, Thomas Swan, to develop a scalable and patentable process that controls the composition and molecular weight range of resulting peptide hydrolysates each with their own unique bioactivity and targeted to specific markets. To enable revenues within a reasonable timeframe, we will focus initially on personal care applications (skincare, haircare) where a high demand for such peptides already exists and is proportionally regulated.