High-Value Biorenewable Peptides from Proteinaceous Biomass

Bell & Loxton Innovations是一家高度创新的循环经济公司，从南德文郡的一个农场衍生出来。我们的联盟已经认识到从丰富的农业和食品加工共流中生产高价值生物可再生（HVB）材料的机会。在榨油过程中产生的油籽榨汁和酿造用的酵母和谷物等许多共流都富含蛋白质，通常被丢弃或用于低经济价值的下游应用。来自不同天然来源的蛋白质在流行度和序列方面都具有独特的氨基酸组成。因此，这些生物可再生蛋白质的蛋白质水解将产生不同大小、氨基酸组成和序列的小肽的独特分布。由于不同的多肽具有不同的生物学特性，这种多样性使不同的高价值市场部门能够得到满足，例如营养、个人护理和药品。从历史上看，定制肽是由化学/化石燃料原料以高成本化学合成的。确定独特的高价值生物可再生蛋白质，然后生产定制的肽和混合物（水解物），将使循环经济方法能够为多个工业部门提供服务，从而对环境有利。我们的联盟汇集了发展成功和可扩展的“绿色”化学品业务的必要部分：贝尔和洛克斯顿创新公司拥有丰富的农业、食品和农业生产经验，生物可再生能源发展中心（BDC）拥有对废物和共流增值技术的深入了解，托马斯斯旺有限公司是一家成熟的化学品制造企业，能够扩大生产规模，同时实现100%生物可再生原料的使命。在与BDC进行的成功的估值可行性研究之后，我们将继续这个项目，与我们的市场制造伙伴Thomas Swan合作，开发一种可扩展和可专利的工艺，控制所产生的肽水解物的组成和分子量范围，每种肽水解物都有自己独特的生物活性，并针对特定市场。为了在合理的时间范围内实现收入，我们将首先关注个人护理应用（护肤，护发），这些应用已经存在对此类肽的高需求并按比例进行调节。

Bell & Loxton Innovations is a highly innovative, circular-economy spin-out from a working farm in South Devon. Our consortium has recognised an opportunity to produce high-value biorenewable (HVB) materials from abundant agricultural and food-processing co-streams. Many co-streams such as oilseed presscake created during oil extraction and spent brewing yeast and grain are high in protein and are routinely discarded or used downstream in low-economic value applications. Proteins from different natural sources have unique compositions of amino acids both in prevalence and in terms of their sequence. Consequently, proteolysis of these biorenewable proteins will create unique distributions of smaller peptides that differ in size, amino acid compositions and sequence. This diversity enables different high-value market sectors to be catered for such as nutrition, personal care and pharmaceuticals as different peptides have different biological properties.Historically, bespoke peptides have been chemically synthesised at high cost from chemical/fossil fuel feedstocks. Identifying unique high-value biorenewable proteins and then producing tailored peptides and blends (hydrolysates) will enable a circular economy approach to supplying multiple industry sectors with a consequent benefit to the environment.Our consortium brings together the necessary parts for developing a successful and scalable 'green' chemicals business: Bell & Loxton Innovations with its strong farming, food and agricultural production experience, The Biorenewables Development Centre (BDC) with its in-depth knowledge of waste and co-stream valorisation techniques, and Thomas Swan & Co Ltd as an established chemicals manufacturing business to enable scale-up production coupled with a mission to move to 100% biorenewable feedstocks.Continuing this project from a successful valorisation feasibility study conducted with the BDC, we will work with our route to market manufacturing partner, Thomas Swan, to develop a scalable and patentable process that controls the composition and molecular weight range of resulting peptide hydrolysates each with their own unique bioactivity and targeted to specific markets. To enable revenues within a reasonable timeframe, we will focus initially on personal care applications (skincare, haircare) where a high demand for such peptides already exists and is proportionally regulated.