High-Value Biorenewable Peptides from Proteinaceous Biomass

来自蛋白质生物质的高价值生物可再生肽

• 批准号: 10017038
• 金额: $ 40万
• 依托单位: BELL & LOXTON INNOVATIONS LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10017038
• 关键词: Value; Biorenewable; Peptides; Proteinaceous; Biomass

Bell & Loxton Innovations is a highly innovative, circular-economy spin-out from a working farm in South Devon. Our consortium has recognised an opportunity to produce high-value biorenewable (HVB) materials from abundant agricultural and food-processing co-streams. Many co-streams such as oilseed presscake created during oil extraction and spent brewing yeast and grain are high in protein and are routinely discarded or used downstream in low-economic value applications. Proteins from different natural sources have unique compositions of amino acids both in prevalence and in terms of their sequence. Consequently, proteolysis of these biorenewable proteins will create unique distributions of smaller peptides that differ in size, amino acid compositions and sequence. This diversity enables different high-value market sectors to be catered for such as nutrition, personal care and pharmaceuticals as different peptides have different biological properties.Historically, bespoke peptides have been chemically synthesised at high cost from chemical/fossil fuel feedstocks. Identifying unique high-value biorenewable proteins and then producing tailored peptides and blends (hydrolysates) will enable a circular economy approach to supplying multiple industry sectors with a consequent benefit to the environment.Our consortium brings together the necessary parts for developing a successful and scalable 'green' chemicals business: Bell & Loxton Innovations with its strong farming, food and agricultural production experience, The Biorenewables Development Centre (BDC) with its in-depth knowledge of waste and co-stream valorisation techniques, and Thomas Swan & Co Ltd as an established chemicals manufacturing business to enable scale-up production coupled with a mission to move to 100% biorenewable feedstocks.Continuing this project from a successful valorisation feasibility study conducted with the BDC, we will work with our route to market manufacturing partner, Thomas Swan, to develop a scalable and patentable process that controls the composition and molecular weight range of resulting peptide hydrolysates each with their own unique bioactivity and targeted to specific markets. To enable revenues within a reasonable timeframe, we will focus initially on personal care applications (skincare, haircare) where a high demand for such peptides already exists and is proportionally regulated.

贝尔和洛克斯顿创新公司是一家高度创新的循环经济公司，来自南德文郡的一个农场。我们的联盟已经认识到有机会从丰富的农业和食品加工并流中生产高价值的生物可再生（HVB）材料。许多共流，例如在油提取过程中产生的油籽压饼和废啤酒酵母和谷物，蛋白质含量高，通常被丢弃或用于低经济价值的下游应用。来自不同天然来源的蛋白质在普遍性和它们的序列方面都具有独特的氨基酸组成。因此，这些生物可再生蛋白质的蛋白水解将产生在大小、氨基酸组成和序列上不同的较小肽的独特分布。这种多样性使不同的高价值市场部门能够得到满足，例如营养品、个人护理和药品，因为不同的肽具有不同的生物特性。历史上，定制肽是以高成本从化学/化石燃料原料化学合成的。鉴定独特的高价值生物可再生蛋白质，然后生产定制的肽和混合物（水解产物）将实现循环经济方法，为多个工业部门提供服务，从而对环境有利。我们的财团汇集了开发成功且可扩展的“绿色”化学品业务的必要部分：Bell &洛克斯顿创新公司拥有丰富的农业、食品和农业生产经验，生物可再生能源开发中心（BDC）拥有对废物和同流价值评估技术的深入了解，和托马斯天鹅有限公司作为一个成熟的化学品制造企业，使规模化生产加上使命转移到100%生物可再生原料。继续从一个成功的价值评估可行性研究与BDC进行这个项目，我们将与我们的路线到市场的制造合作伙伴，托马斯天鹅，开发一种可扩展和可申请专利的工艺，控制所得肽水解产物的组成和分子量范围，每种肽水解产物都具有其独特的生物活性，并针对特定市场。为了在合理的时间范围内实现收入，我们将首先专注于个人护理应用（护肤，护发），其中对此类肽的需求已经很高，并按比例进行监管。