SYNTHESIS OF RADIOSENSITIZING AGENTS

放射增敏剂的合成

• 批准号: 3614814
• 负责人: MARTIN TRACEY
• 金额: $ 49.71万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1990-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3614814
• 关键词: cytotoxicity; drug design /synthesis /production; hamsters; human tissue; nitrogenous heterocyclic compound; radiation dosage; radiosensitizer; tissue /cell culture

The objectives of this contract are to design, synthesize and characterize new and/or novel non-nitro radiosensitizers. The contractor is expected to develop the leads which result from the screening effort (NCI contract N01-CM-67868), which evaluates compounds for their radiosensitivity activity. The contractor is expected to synthesize analogs of the lead compounds and develop in vitro and in vivo data on the efficacy of these compounds as radiosensitizers. New radiosensitizers for clinical use are expected from this contract.

本合同的目的是设计、综合和表征