High-throughput discovery of natural product fungicides targeting Zymoseptoria tritici

针对小麦发酵腐霉的天然产物杀菌剂的高通量发现

• 批准号: 10003775
• 金额: $ 37.37万
• 依托单位: BACTOBIO LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10003775
• 关键词: throughput; discovery; natural; product; fungicides

_Z. tritici_ is the most damaging wheat pathogen, responsible for yield losses of up to 50% annually. Farmers use up to 3 fungicide applications to manage this disease, but widespread use of chemical fungicides is causing pathogen resistance. We urgently need novel fungicides. This project will exploit Baccuico's library of natural compound-producing bacteria to target field samples of _Z. tritici_ provided by CHAP. We're developing a rapid and high-throughput screen to find 5 -- 10 active natural compounds before confirming their activity in plants in CHAPs industrial and environmentally controlled greenhouses as a safer, greener alternative to chemical fungicides.

Z.小麦赤霉病是最具破坏性的小麦病原体，每年造成高达50%的产量损失。农民使用多达3种杀真菌剂来控制这种疾病，但化学杀真菌剂的广泛使用正在导致病原体耐药性。我们迫切需要新的杀菌剂。该项目将利用Baccuico的天然化合物生产细菌库来针对_Z的现场样品。trilliant_由trilliant提供。我们正在开发一种快速和高通量的筛选方法，以找到5 - 10种活性天然化合物，然后确认它们在CHAP工业和环境控制温室中的植物中的活性，作为化学杀真菌剂的更安全，更绿色的替代品。