Exploiting soil microbiomes for development of natural fungicides targeting P. infestans

利用土壤微生物群开发针对致病疫霉的天然杀菌剂

• 批准号: 10026048
• 金额: $ 36.99万
• 依托单位: BACTOBIO LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10026048
• 关键词: Exploiting; soil; microbiomes; development; natural

Potato late blight is one of the most damaging diseases facing England's crops. Untreated, it can devastate crops within 2 weeks of infection. Each year the disease is estimated to cause £3.5Bn in direct losses and control costs, including £800Mn in EU and UK alone.Managing blight requires the most fungicide applications of any crop in the UK, with growers using an average of 10 or up to 20 treatments to ensure yield (vs 1-3 fungicide treatments used on other major crops). Such extensive use of synthetic chemicals is resulting in resistance build-up and widespread environmental damage.With all of today's solutions either at-risk of resistance build-up or regulator removal, new solutions are needed now to prevent the spread of resistant varieties, maintain future crop security and meet demands for improving agricultural efficiencies.Using a combination of cutting-edge synthetic biology, directed evolution, machine learning and bioinformatics approaches, we aim to analyse soil microbiomes from 10 UK potato farms and identify 5 novel bacterially-derived fungicides against _P. infestans._ Discovery of new fungicides against this major global pathogen will provide a compelling case for further investment from key global agricultural players.Overall, our aim is to provide growers with more effective, more sustainable options for crop protection against late blight and to safeguard England's potato industry into the future. This ambition aligns with UK Plant Science Research Strategy to develop better, greener soil management practices and will support farmers in achieving the UK's ambitions to boost productivity and reduce the environmental impact of farming for sustainable potato production.

马铃薯晚疫病是英国作物面临的最具破坏性的疾病之一。未经治疗，它可以在感染后2周内使作物枯萎。据估计，每年该病造成的直接损失和防治费用为35亿英镑，其中仅在欧盟和英国就有8亿英镑。在英国，管理枯萎病需要使用最多的杀菌剂，种植者平均使用10或多达20种杀菌剂来确保产量（相比之下，其他主要作物使用1-3种杀菌剂）。合成化学品的广泛使用导致了抗药性的增强和广泛的环境破坏。由于目前所有的解决方案都存在抗药性增强或调节剂去除的风险，现在需要新的解决方案来防止抗药性品种的传播，维护未来的作物安全并满足提高农业效率的需求。结合尖端合成生物学、定向进化、利用机器学习和生物信息学方法，我们的目标是分析来自10个英国马铃薯农场的土壤微生物组，并确定5种新型细菌衍生的杀真菌剂。针对这一全球主要病原体的新型杀菌剂的发现将为全球主要农业参与者的进一步投资提供令人信服的理由。总的来说，我们的目标是为种植者提供更有效、更可持续的作物保护选择，以防止晚疫病，并保护英格兰的马铃薯产业走向未来。这一雄心与英国植物科学研究战略相一致，以开发更好，更绿色的土壤管理实践，并将支持农民实现英国提高生产力和减少农业对可持续马铃薯生产的环境影响的雄心。