NEUROPHYSIOLOGICAL CORRELATES

这项研究计划的总体目标是调查 关于慢性乙醇神经毒性的性质的重要问题。 慢性乙醇治疗(CET)在慢性酒精中毒中的作用 将在大鼠身上调查营养控制的条件 评估突触功能的神经生理学测量。海马体 将被用作模型神经系统来检验其特性和 破坏性和可能的补偿性改变的参数 由CET制作。研究计划分为以下几个部分 分类：1)突触改变的进一步特征 海马区的功能对CET的反应。在本系列中 将使用细胞外场电位记录技术来评估 突触强度、分布和可塑性在一些固有的 海马区传入神经。2)三叉神经连合纤维的研究 作为乙醇潜在敏感靶点的海马体 神经毒性。3)CET对患者术后功能恢复的影响 大脑损伤将使用生理学技术进行评估。4)分析 CET后不同海马区复发性抑制的差异。5) 开发多种神经生理学制剂的计划 以评估乙醇神经毒性的潜在机制。 从这个动物模型中获得的信息将有助于描述 长期接触酒精和酒精所产生的大脑变化的基质 将增加不断增长的数据库，从这些数据库中可以预防和治疗 可以开发治疗人类酒精中毒的技术并 修改过的。

The overall objective of this program of research is to investigate important questions regarding the nature of chronic ethanol neurotoxicity. The effect of chronic ethanol treatment (CET) under nutritionally-controlled conditions will be investigated in the rat using neurphysiological measures to assess synaptic function. The hippocampus will be used as a model neural system to examine the characteristics and parameters of the destructive and possible compensatory alterations produced by CET. The research plan is devided into the following categories: 1) Further characterization of alterations in synaptic function in the hippocampus in response to CET. In this series extracellular field potential recording techniques will be used to assess synaptic strength, distribution and plasticity in a number of intrinsic hippocampal afferents. 2) Investigation of the commissural fibers of the hippocampus as a potentially sensitive target site of ethanol neurotoxicity. 3) The effect of CET on functional recovery following brain damage will be assessed using physiological techniques. 4) Analysis of recurrent inhibition in different hippocampal subfields after CET. 5) Plans for the development multiple neurophysiological preparations of the hippocampus to evaluate the potential mechanisms of ethanol neurotoxicity. The information derived from this animal model will serve to characterize the matrix of changes in brain produced by prolonged ethanol exposure and will add to the growing data base from which preventative and therapeutic techniques for the treatment of human alcoholism can be developed and modified.