NEUROPHYSIOLOGICAL CORRELATES

这项研究计划的总体目标是调查 关于慢性乙醇神经毒性性质的重要问题。 慢性乙醇治疗（CET）的影响， 将在大鼠中研究营养控制条件， 神经生理学测量以评估突触功能。 海马 将被用作模型神经系统来检查特性， 破坏性和可能的补偿性改变的参数 由CET制作。 研究计划分为以下几个部分 类别：1）突触改变的进一步表征 海马体对CET的反应。 在这个系列中 细胞外场电位记录技术将用于评估 突触强度、分布和可塑性在一些内在的 海马传入神经 2)连合纤维的研究 海马作为乙醇潜在敏感靶点 神经毒性 3)CET对烧伤后功能恢复的影响 将使用生理技术评估脑损伤。 4)分析 CET后海马不同亚区的再发抑制。 第五章） 开发多种神经生理学制剂的计划 海马，以评估乙醇神经毒性的潜在机制。 来自该动物模型的信息将用于表征 长时间接触乙醇产生的大脑变化矩阵， 将增加不断增长的数据库， 可以开发治疗人类酒精中毒的技术， 修改.

The overall objective of this program of research is to investigate important questions regarding the nature of chronic ethanol neurotoxicity. The effect of chronic ethanol treatment (CET) under nutritionally-controlled conditions will be investigated in the rat using neurphysiological measures to assess synaptic function. The hippocampus will be used as a model neural system to examine the characteristics and parameters of the destructive and possible compensatory alterations produced by CET. The research plan is devided into the following categories: 1) Further characterization of alterations in synaptic function in the hippocampus in response to CET. In this series extracellular field potential recording techniques will be used to assess synaptic strength, distribution and plasticity in a number of intrinsic hippocampal afferents. 2) Investigation of the commissural fibers of the hippocampus as a potentially sensitive target site of ethanol neurotoxicity. 3) The effect of CET on functional recovery following brain damage will be assessed using physiological techniques. 4) Analysis of recurrent inhibition in different hippocampal subfields after CET. 5) Plans for the development multiple neurophysiological preparations of the hippocampus to evaluate the potential mechanisms of ethanol neurotoxicity. The information derived from this animal model will serve to characterize the matrix of changes in brain produced by prolonged ethanol exposure and will add to the growing data base from which preventative and therapeutic techniques for the treatment of human alcoholism can be developed and modified.