A rapid and inexpensive point of care diagnostic for SARS-CoV-2 infection
A rapid and inexpensive point of care diagnostic for SARS-CoV-2 infection
批准号:
10163296
负责人:
Matthew Bogyo
金额:
$35.48万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-07-01 至 2021-06-30
关键词:
2019-nCoVAmidesBiological AssayCOVID-19CellsCellular PhoneClinicClinicalClinical TrialsCyclic PeptidesDataDetectionDiagnosisDiagnosticDiagnostic testsEquipmentFood SafetyFoundationsHandHumanImmune responseIndustrializationIndustryInfectionLasersLibrariesLightLocationLow incomeMeasuresMolecularNonprofit OrganizationsPatientsPeptide HydrolasesPersonsPhotonsPositioning AttributePreparationProcessProtocols documentationPublic HealthRecombinantsRecording of previous eventsRecoveryReporterReportingResourcesSalivaSamplingSideSignal TransductionSocial DistanceTechnologyTest ResultTestingUnited StatesViralVirusVirus DiseasesVisible RadiationWidespread Diseasechemical reactionclinically relevantcommercializationcostdesigndetectorepidemiology studyfirst-in-humanin vitro Modelnovelpandemic diseaseparent grantpathogenpoint of carepoint-of-care diagnosticsprotein aminoacid sequencesmall moleculevalidation studiesviral RNA
中文摘要
项目总结
英文摘要
Project Summary
The project outlines our plans to develop a rapid, point-of-care diagnostic test for the novel SARS-CoV-2 virus that can be used in resource-limited locations. The foundation of the project is a highly selective chemiluminescent reporter probe that produces light when activated by the major viral protease SARS-CoV-2 Mpro. This approach will enable rapid testing (<30 min) of easily obtained clinical samples (i.e., saliva) using a detector that has limited power needs and that can interface with standard smart phones to provide a diagnosis.
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海外基金