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中文摘要
翻译
项目摘要 该项目概述了我们的计划,即开发一种可用于资源有限地区的新型SARS-CoV-2病毒的快速即时诊断测试。该项目的基础是一种高选择性的荧光报告探针,当被主要的病毒蛋白酶SARS-CoV-2 Mpro激活时,它会产生光。这种方法将能够快速测试(<30分钟)容易获得的临床样品(即,唾液),该检测器具有有限的功率需求并且可以与标准智能电话接口以提供诊断。
英文摘要
Project Summary The project outlines our plans to develop a rapid, point-of-care diagnostic test for the novel SARS-CoV-2 virus that can be used in resource-limited locations. The foundation of the project is a highly selective chemiluminescent reporter probe that produces light when activated by the major viral protease SARS-CoV-2 Mpro. This approach will enable rapid testing (<30 min) of easily obtained clinical samples (i.e., saliva) using a detector that has limited power needs and that can interface with standard smart phones to provide a diagnosis.
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Covalent inhibitors of host cell entry by SARS-CoV-2 for treatment of COVID-19
  • 批准号:
    10377746
  • 项目类别:
  • 资助金额:
    $19.68万
  • 财政年份:
    2022
  • 负责人:
    Matthew Bogyo
  • 依托单位:
Covalent inhibitors of host cell entry by SARS-CoV-2 for treatment of COVID-19
  • 批准号:
    10611435
  • 项目类别:
  • 资助金额:
    $23.61万
  • 财政年份:
    2022
  • 负责人:
    Matthew Bogyo
  • 依托单位:
Targeting bacterial proteases involved in PAR signaling to treat inflammatory bowel diseases
  • 批准号:
    10389858
  • 项目类别:
  • 资助金额:
    $50.97万
  • 财政年份:
    2021
  • 负责人:
    Matthew Bogyo
  • 依托单位:
Targeting bacterial proteases involved in PAR signaling to treat inflammatory bowel diseases
  • 批准号:
    10670358
  • 项目类别:
  • 资助金额:
    $45.8万
  • 财政年份:
    2021
  • 负责人:
    Matthew Bogyo
  • 依托单位:
海外基金