Identification, Surveillance, and Control of Vector-Borne and Zoonotic Infectious Diseases in Uganda

乌干达媒介传播疾病和人畜共患传染病的识别、监测和控制

• 批准号: 10160724
• 负责人: JULIUS JULIAN LUTWAMA
• 金额: $ 279.36万
• 依托单位: UGANDA VIRUS RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10160724
• 关键词: Identification; Surveillance; Control; Vector; Borne

Project Abstract: While outbreaks of new, exotic infectious diseases, as well as the resurgence of old killer diseases, have surfaced all over the globe in the past decades, no continent has been harder hit than Africa. Sub-Saharan Africa is among the most affected region and is often referred to as the “Infectious Continent.” Africa is faced with the greatest burden of old and new infectious diseases, and yet it has very low levels of resource to manage them. Uganda, like much of sub-Saharan Africa, has had numerous highly infectious disease outbreaks occurring concurrently or in very quick succession over the past few years. Presently, there is an outbreak of Crimean Congo Hemorrhagic Fever virus infection among people. Over 15 cases have been diagnosed in the past few months. In the past 2 years, Uganda has been experiencing Rift Valley Fever Virus outbreaks together with Yellow Fever virus and Marburg virus outbreaks. There is need for precise and effective targeting of resources, where laboratory disease detection, identification, monitoring, risk mapping and assessment systems are put in place as the best strategy to stop disease spread at an early stage or preventing them altogether. The aim of this proposal is to describe a multiyear project investigating and controlling vector-borne and zoonotic disease in Uganda. Our proposal is to improve and maintain an effective, coordinated program of diagnostics and surveillance of vector-borne infections and High Hazard Hemorrhagic Fever Viruses to collect data and information on the diseases, vectors and reservoir systems, ensuring prompt recognition and confirmation of disease outbreaks which would enable action to be taken before the diseases have affected many people, thereby reducing morbidity and mortality. We aim to investigate, characterize and control environmental and faunal aspects of filovirus outbreaks in Uganda and neighboring countries. In under-resourced countries, like Uganda, the impact of infectious diseases is often devastating - decreasing survival rates, particularly among children, and impeding opportunities for economic growth and development. Ultimately, national surveillance systems need to be strong enough to provide not only constant alert and rapid response to outbreaks of known endemic diseases, but also ready to respond to a sudden unexpected outbreak of an unknown disease. Early detection of diseases, through improved laboratory and field surveillance, new diagnostic tools, risk mapping, and continued monitoring as envisaged in this proposal will assist to alleviate poverty, suffering and death of the Ugandans due to zoonotic and vector-borne diseases. In this proposal we are requesting for assistance of in funding of US $ 2,999,978.00 to sustain and improve systems of surveillance and detection of diseases to reduce morbidity and mortality in affected people as well as reduce spread of the diseases to other areas. This proposal will be a collaboration of the Uganda Virus Research Institute (UVRI), together with different Branches of the US Centers for Diseases Control and Prevention, USA.

项目摘要：随着新的、外来传染病的爆发，以及旧杀手的死灰复燃， 在过去的几十年里，各种疾病在地球仪上到处出现，但没有哪个大陆比非洲受到的打击更严重。 撒哈拉以南非洲是受影响最严重的地区之一，通常被称为“传染大陆”。 非洲面临着新旧传染病的最大负担，但它的发病率很低， 资源来管理它们。乌干达和撒哈拉以南非洲的许多国家一样， 在过去几年中同时或非常迅速地连续发生的疾病爆发。目前， 克里米亚刚果出血热病毒在人群中爆发。超过15例 在过去的几个月里被诊断出来。在过去的2年里，乌干达一直在经历裂谷， 发热病毒暴发与黄热病毒和马尔堡病毒暴发一起。有必要 精确和有效的资源定位，其中实验室疾病检测，识别，监测， 建立风险绘图和评估系统，作为阻止疾病传播的最佳战略， 早期阶段或完全阻止它们。本提案的目的是描述一个多年期项目 在乌干达调查和控制病媒传播和人畜共患疾病。我们的建议是改善和 维持有效、协调的病媒传染病诊断和监测方案， 收集关于高危险性出血热病毒的疾病、病媒和 水库系统，确保迅速识别和确认疾病爆发， 在疾病影响到许多人之前采取行动，从而降低发病率和死亡率。 我们的目标是调查、描述和控制非洲丝状病毒暴发的环境和动物方面。 乌干达和邻国。在资源不足的国家，如乌干达， 疾病往往是毁灭性的--降低生存率，特别是儿童的生存率，并阻碍 经济增长和发展的机会。最终，国家监测系统需要 强大到不仅能够对已知的地方性疾病的爆发提供持续的警报和快速反应， 疾病，但也准备应对突然爆发的未知疾病。早期 通过改进实验室和实地监测、新的诊断工具、风险绘图， 本建议所设想的持续监测将有助于减轻贫困、痛苦和死亡， 由于动物传染病和病媒传播的疾病，乌干达人受到严重影响。在这份提案中，我们请求协助 提供2 999 978.00美元，用于维持和改进疾病监测和检测系统 降低受影响人群的发病率和死亡率，并减少疾病向其他地区的传播。 这项提案将是乌干达病毒研究所（UVRI）的合作， 美国疾病控制和预防中心的分支机构。