Biological Bases of Drug-Seeking Behavior

项目摘要/摘要 这一博士后和博士后培训计划支持对有能力进行 从分子水平到认知/临床水平的生物学机制的临床前研究 是发展、维持和消除吸毒行为的基础。二十三名成员 俄勒冈健康与科学大学(OHSU)的研究生教师担任博士后导师 研究人员和博士生进入基础科学研究生课程的行为 神经科学、神经科学、生理学和药理学或生物化学。主要研究领域代表 四个层次。一些教员主要在细胞/分子水平上工作，使用分子生物学、细胞 生物学和电子显微镜技术。其他教职人员主要从事生理学、 生物化学和药物系统，使用受体结合，放射自显影，体内微透析和 伏安法和电生理技术，以及一些主要在行为药理学和 药物遗传学，使用行为测试，静脉给药，数量遗传学和 基因图谱，以及计算机建模技术。最后，一些教员研究人类受试者， 使用认知测试和各种成像技术。现有教职员工广泛合作的领域 包括：多巴胺能系统的研究，从分子生物学到行为学；广泛的研究 药物反应的遗传决定因素，从分子到统计基因图谱；以及这项研究 对药物反应的获得性和非获得性决定因素，特别是它们的奖赏效应和药物自身 行政管理。所有主要类别药物的敏感性、耐受性和依赖/停药现象 虐待行为正在积极调查中。培训包括扎实的基础科学基础，特别是 关于滥用药物的药理学培训，以及广泛和持续地参与研究。实习生 还通过互动研讨会接受负责任的研究工作的广泛指导 涵盖科学方方面面的伦理考虑。OHSU和这一培训计划已经投入了相当多的资金 努力招聘和留住来自不同背景的受训人员。这些努力已经产生了一个 接受生物学培训的研究生和博士后研究员明显更加多样化 寻毒行为的基础。

Project Summary / Abstract This program for pre- and post-doctoral training supports the training of specialists who are able to conduct preclinical research at levels ranging from the molecular to the cognitive/clinical on the biological mechanisms underlying the development, maintenance, and elimination of drug-seeking behavior. Twenty-three members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for postdoctoral research fellows and for Ph.D. students matriculating into basic science graduate programs in behavioral neuroscience, neuroscience, physiology and pharmacology, or biochemistry. Major research areas represent four levels. Some faculty members work primarily at the cellular/molecular level, using molecular biological, cell biological, and electron microscopic techniques. Other faculty work principally at the level of physiological, biochemical and pharmacological systems, using receptor binding, autoradiography, in vivo microdialysis and voltammetry, and electrophysiological techniques, and some work primarily in behavioral pharmacology and pharmacogenetics, using behavioral testing, intravenous drug self-administration, quantitative genetics and genetic mapping, as well as computer modelling techniques. Finally, some faculty work with human subjects, using cognitive testing and a variety of imaging techniques. Areas of extensive existing faculty collaboration include: studies of dopaminergic systems, ranging from molecular biology to behavior; extensive studies of genetic determinants of drug responses, at all levels from molecular to statistical gene mapping; and the study of learned and unlearned determinants of responses to drugs, particularly their rewarding effects and drug self- administration. Sensitivity, tolerance, and dependence/withdrawal phenomena for all major classes of drugs of abuse are under active investigation. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in abused drugs, and extensive and continuous participation in research. Trainees also receive extensive instruction in the responsible conduct of research through interactive seminars that cover ethical considerations in all aspects of science. OHSU and this training program have put considerable efforts into recruiting and retaining trainees from diverse backgrounds. These efforts have resulted in a significantly more diverse pool of graduate students and postdoctoral fellows receiving training in the biological basis of drug-seeking behavior.