UT Southwestern Integrated Program for the Advancement of Neuroscience Research Careers

项目总结/摘要 临床医生-科学家处于独特的地位，可以弥合发现和神经治疗之间的差距（ 神经疾病治疗的开发和实施）。尽管有大量的机会 对于新的科学发现，特别是在神经科学领域， 职业生涯一直在下降。鼓励医生科学家的计划由NIH发起，几个不是- 营利性机构很有希望，但申请早期职业发展奖的人数 专注于临床或以患者为导向的研究，如K 08和K23，自2005年以来一直在稳步下降（NIH 数据书：研究职业发展趋势（K）奖）。有前途的年轻医生科学家 他们在科学生涯中遇到重大障碍，包括长期培训 持续时间，财务挑战，未来支持的不确定性，有限的高质量研究，以及缺乏 有效的榜样和导师。因此，迫切需要鼓励临床神经科学家， 继续研究，并在临床实习和奖学金期间提供专家科学职业发展 训练UT西南神经科学研究职业发展综合计划 (UT SWANS）旨在为未来的临床神经科学家做好准备，将基础科学发现转化为 通过消除成功的障碍来实现临床相关的治疗。UT SWANS将保护研究时间， 居住和奖学金培训，提供特殊的指导，并给予先进的研究培训， 神经病学（成人和儿科）、神经外科、神经病理学和急诊医学的住院医师， 对研究有浓厚的兴趣。UT SWANS导师的多元化名册包括完善的 基础、临床和转化研究的研究人员。该计划将有一个综合的，多学科的 研究培训的方法，并将针对参与者的研究教育需求，重点是 神经治疗学的发展，只要有可能。该计划将增加 有才华的个人发展成为未来的领导者在转化研究和临床神经治疗学 research.

PROJECT SUMMARY/ABSTRACT Clinician-scientists are uniquely positioned to bridge the gap between discovery and neurotherapeutics (the development and implementation of treatments for neurological disease). In spite of substantial opportunities for new scientific discoveries, in the neurosciences particularly, the number of physicians choosing research careers has been declining. Programs to encourage physician scientists initiated by the NIH and several not- for-profit institutions were promising, but the number of applications for Early Career Development Awards focused on clinical or patient-oriented research, such as K08 and K23, has steadily declined since 2005 (NIH Data Book: Trends in Research Career Development (K) Awards). Promising young physician-scientists experience significant obstacles as they progress in their science careers, which include extended training duration, financial challenges, uncertainty about future support, limited exposure to quality research, and lack of effective role models and mentors. Thus, there is a pressing need to encourage clinician-neuroscientists to continue in research and provide expert scientific career development during clinical residency and fellowship training. The UT Southwestern Integrated Program for the Advancement of Neuroscience Research Careers (UT SWANS) is designed to prepare future clinician-neuroscientists to translate basic science discoveries into clinically-relevant treatments by removing barriers to success. UT SWANS will protect research time during residency and fellowship training, provide exceptional mentoring and give advanced research training to residents in Neurology (adult and pediatric), Neurosurgery, Neuropathology, and Emergency Medicine who have an strong interest in research. The diverse roster of UT SWANS mentors includes well-established researchers in basic, clinical and translational research. The program will have an intergrated, multidisciplinary approach to research training and will be tailored to the participant's research educational needs, with a focus on the development of neurotherapeutics, whenever possible. This program will increase the likelihood that talented individuals develop into the future leaders in translational research and clinical neurotherapeutics research.