Core M: Implementation Science

摘要 艾滋病毒预防和治疗干预措施的进展，以及前所未有的投资 使这些干预措施规模化，为预防新的感染提供了机会，避免了艾滋病毒相关的发病率 并极大地改变了艾滋病毒/艾滋病的流行。然而，最近科学研究的全部潜力 艾滋病毒治疗和预防方面的进展尚未实现，有效的干预措施尚未得到 充分扩展到有效的项目中。实施科学可以提高对 这些方案，并在人口层面影响健康。鉴于当务之急是将基于证据的 对广泛实施的项目的干预，实施科学是NIH的科学优先事项， 国内和全球公共卫生机构，以及华盛顿大学/弗雷德·哈奇CFAR成员。 华盛顿大学/弗雷德·哈奇CFAR是将实施科学研究与公共卫生联系起来的理想地点 在美国和全球范围内的项目。我们的CFAR教职员工在定义多学科、 实施科学研究方法，并制定了新的公共卫生和 实施科学。此外，CFAR附属调查人员领导各种计划来实施和 扩大艾滋病毒预防和治疗干预措施，与 美国和世界各地的卫生部门。 我们建议建立一个新的实施科学核心，以发展实施科学 CFAR社区内的专门知识，促进新的跨学科实施科学研究，以及 将华盛顿大学的研究和公共卫生活动联系起来，以促进现实世界公共卫生中的实施科学 设置。这一努力将为初级研究人员创造新的培训机会，导致新的和创新的 研究，并最终提高努力转化科学证据的速度、效率和质量 将艾滋病毒预防和护理纳入有效的大规模健康计划。ISC的具体目标是：1)制造艾滋病毒 研究能力和促进地方、国家和国际学术-公共卫生合作 通过短期课程、研讨会和在线培训与实施研究有关；以及2) 增加外部资助、国内和国际实施的科研项目 学术机构和公共卫生机构的参与。为了实现这些目标，ISC将支持 培训和研讨会，以培养研究人员与实施科学有关的技能，并吸引新的研究人员 进入该领域；为初级教员组成一个导师小组，旨在促进新竞争对手的发展 研究建议；为CFAR附属研究人员提供咨询和分析专业知识 在与实施科学有关的领域应用和支持正在进行的项目；并建立联系 CFAR调查人员与国际和国内卫生部门之间的合作，以识别和培养 合作研究。

Abstract Advances in HIV prevention and treatment interventions, together with unprecedented investments to bring these interventions to scale, presents an opportunity to prevent new infections, avert HIV-related morbidity and mortality, and dramatically alter the HIV/AIDS epidemic. However, the full potential of recent scientific advances in HIV treatment and prevention has yet to be realized, and efficacious interventions have not been adequately scaled into effective programs. Implementation science can improve the uptake and effectiveness of these programs, and impact health at the population level. Given the imperative to translate evidence-based interventions into widely implemented programs, implementation science is a scientific priority for the NIH, domestic and global public health agencies, and UW/Fred Hutch CFAR members. The UW/Fred Hutch CFAR is ideally situated to link implementation science research with public health programs both within the U.S., and globally. Our CFAR faculty is at the forefront in defining multidisciplinary, implementation science research methods, and has developed novel training curricula in public health and implementation science. Furthermore, CFAR-affiliated investigators lead diverse programs to implement and scale-up HIV prevention and treatment interventions that have developed strong, collaborative relationships with health departments throughout the U.S. and internationally. We propose to establish a new Implementation Science Core to develop implementation science expertise within the CFAR community, fostering new interdisciplinary implementation science research, and linking UW’s research and public health activities to promote implementation science in real-world public health settings. This effort will create new training opportunities for junior researchers, lead to new and innovative research, and ultimately improve the speed, efficiency, and quality of efforts to translate scientific evidence on HIV prevention and care into effective, large scale health programs. ISC’s specific aims are: 1) to build HIV research capacity and foster local, national and international academic-public health collaborations related to implementation research though short courses, seminars, and online training; and 2) to increase externally funded, domestic and international implementation science research projects involving academic institutions and public health agencies. To advance these aims, the ISC will support trainings and seminars to build investigators’ skills related to implementation science and draw new researchers into the field; form a mentorship group for junior faculty designed to foster the development of new competitive research proposals; provide consulting and analytic expertise to CFAR-affiliated researchers on grant applications and in support of ongoing projects in areas related to implementation science; and create linkages between CFAR investigators and international and domestic health departments to identify and cultivate collaborative research.