Qualitative and Quantitative Determination of Pesticides in Beverages and Similar Food Matrices by High Performance Liquid Chromatography-Quadrupole Time-of-Flight (HPLC-QToF) Analysis

申请标题：新泽西州食品检测计划--食品安全与防御(2020-2025年) 项目名称：果蔬饮料中农药的定性和定量检测 高效液相色谱-四极杆飞行时间分析 项目摘要-规程D：特殊项目，分析轨道3：方法开发和验证 新泽西州卫生部(NJDOH)正在追查美国食品和药物管理局(FDA) 实验室灵活资助模式合作协议侧重于提高能力和能力 新泽西州要维护食品安全和保障。化学恐怖主义、生物监测、医用大麻和食品 NJDOH环境化学实验室服务内的测试实验室(CT实验室) (ECLS)将参与果汁和蔬菜扩展杀虫剂方法的开发- 基础饮料。食品应急网络(FERN)方法CHE.0006和CHE.0008是 非常适合于筛选食物中的毒素和毒物，包括一些杀虫剂、杀虫剂和除草剂。 然而，这些方法范围很广，不包括商业应用的全部杀虫剂清单和 由于主要是筛查方法，它们的目标分析物水平约为百万分之几(Ppm)。低- 远低于ppm水平的杀虫剂可能不会被检测到，并留在市场的食品中。低水平 如果食用杀虫剂，会带来更大的健康风险，特别是对婴儿或儿童。 为了解决这一食品安全问题，一种高灵敏度的农药方法能够分析超过65种农药 将由CT实验室开发。该实验室将利用其专业知识和经验开发这样一种 大麻测试方法，以创建一种适用于食品的方法，从果汁和蔬菜开始 饮料。这一新方法将把目标分析物的数量扩大到68种以上，包括 新泽西州2015年进行的农药使用调查中列出的大多数农药，将大大降低检测率 限制到十亿分之一(Ppb)级别。这一能力将为FDA提供更多信息，以确定 测量的杀虫剂水平将公众的健康置于危险之中。 CT实验室将使用这种方法支持其他食品农药研究，通过识别和确认 根据FDA的要求，在各种食品中存在杀虫剂。通过执行本文件中详细介绍的工作 提出和管理一个综合的食品安全体系，ECLS将能够扩大其食品防御和 安全活动，同时进一步保障公众健康，并为FDA提供额外的网络能力。

Application Title: New Jersey Food Testing Program - Food Safety and Defense (2020-2025) Project Title: Qualitative and Quantitative Determination of Pesticides in Fruit- and Vegetable-based Beverages by High Performance Liquid Chromatography-Quadrupole Time-of-Flight (HPLC-QToF) Analysis Project Summary – Discipline D: Special Projects, Analytical Track 3: Method Development and Validation The New Jersey Department of Health (NJDOH) is pursuing the U.S. Food and Drug Administration’s (FDA) Laboratory Flexible Funding Model cooperative agreement focused on improving the capability and capacity of NJ to maintain food safety and security. Chemical Terrorism, Biomonitoring, Medicinal Marijuana, and Food Testing Laboratory (CT Laboratory) housed within NJDOH’s Environmental Chemistry Laboratory Services (ECLS) will participate in the method development of an expanded pesticides method for juice- and vegetable- based beverages. The Food Emergency Response Network (FERN) methods CHE.0006 and CHE.0008 are excellent for the screening of food for toxins and poisons, including some pesticides, insecticides, and herbicides. However, these are wide ranging methods that do not include the full list of pesticides applied commercially and because the are primarily screening methods, they target analytes at around parts-per-million (ppm) levels. Low- level pesticides far below ppm levels can go undetected and remain in food items in markets. Low-level pesticides pose greater health risks if consumed, especially for babies or children. To address this food safety issue, a highly sensitive pesticide method capable of analyzing over 65 pesticides will be developed by the CT Laboratory. The laboratory will use its expertise and experience developing such a method for marijuana testing to create a method usable for food stuffs, starting with juice- and vegetable-based beverages. This new method will expand the number of target analytes to more than 68 pesticides, including most of pesticides listed in the NJ Pesticide Use Survey conducted in 2015, and will significantly lower detection limits down to parts-per-billion (ppb) level. This capability will provide more information for the FDA to determine measured pesticide levels that put the public’s health at risk. The CT Laboratory will use this method to support other food pesticide research by identifying and confirming the presence of pesticides in various foods as requested by the FDA. By conducting the work detailed in this proposal and managing an integrated food safety system, ECLS will be able to expand its food defense and safety activities while further safeguarding public health and provide the FDA with additional network capability.