BIOLOGICAL TESTING FACILITY - CONTRACEPTIVE TARGET WEB APPLICATION

早期阶段非甾体避孕药发现和开发的一个主要障碍是受已知目标和容易获得这些信息的限制。重要的是促进避孕目标的发现、管理和可得性，目的是开发新方法以推进下一代安全避孕药物/装置。为了减轻这一障碍，建立了生物信息学驱动的方法，从现有数据库和文献中识别和管理这些靶标。为了进一步方便访问和友好的用户界面，需要一个web应用程序。生物测试设施具有生物信息学、网页设计和应用能力来完成这项任务，此外还允许快速评估（体外和体内）目标物质的新组合物、有效性评估、安全性/毒理学评估、药物配方、输送系统和避孕装置，然后进行临床批量制备/释放和持续的稳定性测试，以在临床试验中进行评估。BTF提供全面的项目管理和能力，以支持新目标产品鉴定、药物发现/优化、临床前活动和避孕药开发的所有阶段，以及导致提交新药研究（IND）申请的相关任务

One major obstacle in early phase non-steroidal contraceptive discovery and development is limited by known targets and readily accessibility of this information. It is important to facilitate the discovery, curation and availability of contraceptive targets with the aim of developing new approaches to advance next generation of safe contraceptive drug/device. To alleviate this obstacle, bioinformatics driven approach to identify and curate those targets from the existing databases as well as from literature was established. To further allow easy accessibility and friendly user interface for this database, a web application is needed. The Biological Testing Facility has bioinformatics and web design and application capability to achieve this task, in addition to permit rapid evaluation (in vitro and in vivo) of new compositions of matter to the target, efficacy evaluation, safety/ toxicology assessment, drug formulations, delivery systems, and devices for contraceptives followed by clinical batch preparation/ release and continued stability testing of drugs to be evaluated in clinical trials. The BTF provides overall project management and the capabilities to support all phases of novel target product identification, drug discovery/ optimization, preclinical activities and development of contraceptives and associated tasks leading to the filing of investigational new drug (IND) applications