Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease

项目摘要 我们建议继续在分子生物学的一个非常成功的培训计划， 神经退行性疾病和阿尔茨海默氏病-一个致力于训练前和 博士后学生在大学和卫生相关领域从事独立研究科学家的职业 研究实验室。培训师都是哈佛大学的教员，他们都有活跃的研究项目 与神经变性有关，重点是阿尔茨海默病和其他神经变性 与衰老有关的疾病他们来自哈佛医学院和六个附属医院 研究医院：贝斯以色列女执事医疗中心，布里格姆妇女医院， 儿童医院、达纳-法伯癌症研究所、马萨诸塞州总医院和姆克林 医院为年龄问题带来了广泛的经验和实验方法- 相关的神经变性，该计划的教师包括分子生物学家，遗传学家，细胞 生物学家、神经病理学家和生物化学家。 博士预科生是从研究生中招收和抽取的， 授予学位的哈佛医学院神经科学项目。博士后 从该计划的个别教师提名的申请人中选择。 受训人员的甄选是通过竞争过程进行的，并由培训补助金咨询委员会进行调解。 以马克思共有六名博士前培训生和八名博士后培训生被提议参加一个 初级培训学院，由26名在与年龄有关的基础和应用研究方面经验丰富的人员组成 神经变性在所有情况下，成功候选人的主要标准是奉献精神和兴趣 在衰老和神经退行性疾病的研究和最高水平的学术成就， 以前的训练。学生必须参加特殊的神经变性课程， 研讨会和座谈会。密切监测学生的进步和职业咨询提供了一个 整个培训过程的有效结构。该计划的目的是建立一个 在这个框架内，对未来致力于老龄化问题的研究人员进行最好的培训， 神经退行性变可能发生，而已经广泛的协作相互作用之间的 课程教师可以在各个级别传播，从学生到教授。

Project Abstract We propose to continue a highly successful Training Program in the Molecular Biology of Neurodegeneration and Alzheimer's disease - a program devoted to the training of pre- and postdoctoral students for careers as independent research scientists in universities and health-related research laboratories. The trainers are all Harvard faculty members with active research programs related to neurodegeneration, with an emphasis on Alzheimer's disease and other neurodegenerative disorders related to aging. They are drawn from the Harvard Medical School and six affiliated research hospitals: Beth Israel-Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, and McLean Hospital. Bringing a wide range of experience and experimental approaches to the problems of age- related neurodegeneration, the Program faculty includes molecular biologists, geneticists, cell biologists, neuropathologists, and biochemists. The predoctoral students are recruited into and drawn from the graduate students in the degree-granting Neuroscience Program of the Harvard Medical School. The postdoctoral students are chosen from among applicants nominated by individual faculty members of the Program. Selection of trainees occurs through a competitive process mediated by a Training Grant Advisory Committee. A total of six predoctoral trainees and eight postdoctoral trainees are proposed for a primary training faculty of 26 individuals experienced in basic and applied studies of age-related neurodegeneration. In all cases, the main criteria for successful candidates is dedication and interest in aging and neurodegeneration research and the highest level of academic achievement in their previous training. Students are required to participate in special neurodegeneration courses, seminars, and symposia. Close monitoring of student progress and career advising provide an effective structure for the entire training process. The purpose of the Program is to create a framework within which the best training of future researchers devoted to problems in aging and neurodegeneration can take place, and the already extensive collaborative interactions among the Program faculty can be propagated at all levels, from student to Professor.