Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease

神经退行性疾病和阿尔茨海默病的分子生物学培训

• 批准号: 10176310
• 负责人: Bruce A YANKNER
• 金额: $ 88.98万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176310
• 关键词: Alzheimer' s Disease; Molecular Biology; Nerve Degeneration; Training

Project Abstract We propose to continue a highly successful Training Program in the Molecular Biology of Neurodegeneration and Alzheimer's disease - a program devoted to the training of pre- and postdoctoral students for careers as independent research scientists in universities and health-related research laboratories. The trainers are all Harvard faculty members with active research programs related to neurodegeneration, with an emphasis on Alzheimer's disease and other neurodegenerative disorders related to aging. They are drawn from the Harvard Medical School and six affiliated research hospitals: Beth Israel-Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, and McLean Hospital. Bringing a wide range of experience and experimental approaches to the problems of age- related neurodegeneration, the Program faculty includes molecular biologists, geneticists, cell biologists, neuropathologists, and biochemists. The predoctoral students are recruited into and drawn from the graduate students in the degree-granting Neuroscience Program of the Harvard Medical School. The postdoctoral students are chosen from among applicants nominated by individual faculty members of the Program. Selection of trainees occurs through a competitive process mediated by a Training Grant Advisory Committee. A total of six predoctoral trainees and eight postdoctoral trainees are proposed for a primary training faculty of 26 individuals experienced in basic and applied studies of age-related neurodegeneration. In all cases, the main criteria for successful candidates is dedication and interest in aging and neurodegeneration research and the highest level of academic achievement in their previous training. Students are required to participate in special neurodegeneration courses, seminars, and symposia. Close monitoring of student progress and career advising provide an effective structure for the entire training process. The purpose of the Program is to create a framework within which the best training of future researchers devoted to problems in aging and neurodegeneration can take place, and the already extensive collaborative interactions among the Program faculty can be propagated at all levels, from student to Professor.

项目摘要 我们建议继续开展非常成功的分子生物学培训计划 神经退行性疾病和阿尔茨海默氏病 - 一个致力于训练前和阿尔茨海默氏病的计划 在大学和健康相关领域担任独立研究科学家的博士后学生 研究实验室。培训师都是哈佛大学的教员，从事活跃的研究项目 与神经退行性疾病相关，重点是阿尔茨海默病和其他神经退行性疾病 与衰老有关的疾病。他们来自哈佛医学院和六个附属机构 研究医院：贝斯以色列女执事医疗中心、布莱根妇女医院、 儿童医院、达纳法伯癌症研究所、马萨诸塞州总医院和麦克莱恩 医院。为解决年龄问题带来广泛的经验和实验方法 相关的神经退行性疾病，该项目的教职人员包括分子生物学家、遗传学家、细胞学家 生物学家、神经病理学家和生物化学家。 博士前生是从研究生中招收和抽选的。 哈佛医学院授予学位的神经科学项目。博士后学生 从该计划的个别教员提名的申请人中选出。 学员的选拔是通过培训补助金咨询介导的竞争过程进行的 委员会。拟招收博士前实习生 6 名，博士后实习生 8 名。 由 26 名在与年龄相关的基础和应用研究方面经验丰富的人员组成的初级培训教师 神经变性。在所有情况下，成功候选人的主要标准是奉献精神和兴趣 在衰老和神经退行性研究方面取得了最高水平的学术成就 之前的训练。学生需要参加特殊的神经退行性疾病课程， 研讨会和座谈会。密切监控学生的进步和职业建议提供了 整个培训过程的有效结构。该计划的目的是创建一个 为致力于老龄化问题的未来研究人员提供最佳培训的框架 神经退行性变可能发生，并且神经元之间已经广泛的协作相互作用 项目教师可以在各个级别上传播，从学生到教授。