Virtual Reality-based Rehabilitation for Children with Traumatic Brain Injuries

基于虚拟现实的脑外伤儿童康复

• 批准号: 10178242
• 负责人: Jiabin Shen
• 金额: $ 24.89万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10178242
• 关键词: 3-Dimensional; Accounting; Address; Adherence; Adverse event; Age; Attention; Award; Brain Injuries; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Child Development; Childhood; Clinical; Clinical Trials; Cognitive; Computer software; Congresses; Control Groups; Coupled; Data; Development; Doctor of Philosophy; Effectiveness; Emotional; Ensure; Family; Fostering; Future; Goals; Grant; Health; Healthcare; Home environment; Immersion; Impaired cognition; Impairment; Inpatients; Internet; Intervention; Interview; Knowledge; Life; Measures; Mediating; Mentors; Mentorship; Mission; National Institute of Child Health and Human Development; Outcome; Outcome Assessment; Pathway interactions; Pediatric Hospitals; Phase; Positioning Attribute; Postdoctoral Fellow; Quality of life; Randomized; Randomized Clinical Trials; Rehabilitation Outcome; Rehabilitation therapy; Reporting; Research; Research Institute; Research Personnel; Research Priority; Research Training; Safety; Sample Size; Scholarship; Scientist; Services; Short-Term Memory; Structure; Technology; Testing; Training; Training Activity; Training Programs; Transferable Skills; Trauma; Trauma Research; Traumatic Brain Injury; Treatment Efficacy; Visit; base; career; career development; cognitive function; cognitive rehabilitation; cognitive skill; cognitive training; computerized; design; disability; evidence base; executive function; experience; flexibility; follow-up; frontal lobe; functional improvement; group intervention; health related quality of life; improved; innovation; long-term rehabilitation; mobile computing; multidisciplinary; novel; pediatric trauma; post intervention; professor; programs; psychologic; recruit; rehabilitation research; research and development; safety and feasibility; severe injury; skills; social rehabilitation; tenure track; theories; virtual environment; virtual reality; virtual reality game; virtual reality system

Jiabin Shen, PhD, is a Research Scientist (postdoc equivalent position) in the Center for Pediatric Trauma Research at The Research Institute at Nationwide Children’s Hospital (NCH). His long-term career goal is to become an accomplished research scientist with a programmatic line of research focused on theory-driven and technology-assisted psychological rehabilitation for childhood TBI. Childhood TBI is a leading cause of acquired disability in U.S. children with 700,000 cases every year, which often result in significant impairment in broad cognitive functions, particularly in executive functions (EFs) that are critical to children’s development, especially in children with moderate to severe TBI. Although the Centers for Disease Control and Prevention (CDC) has identified post-TBI cognitive rehabilitation as the top unmet health care need for children with TBI, interventions specifically designed for children’s EF rehabilitation post-TBI remain unavailable. Virtual reality (VR) offers exciting potential as an alternative strategy for EF rehabilitation of childhood TBI for its flexibility in training content, capability for affordable remote access, and potential of increased adherence and skill transfer. However, the safety/efficacy of VR-based EF rehabilitation of childhood TBI remains to be established. This Pathway to Independence Award (K99/R00) proposal outlines structured career development and research plans aiming to assess the safety and efficacy of an innovative VR-based EF training program for children with moderate to severe TBI. During the K99 phase, Dr. Shen will conduct a small parallel-group randomized clinical trial (RCT) to evaluate the VR research paradigm, safety, and preliminary efficacy of the intervention among 30 children 7-17 years with moderate to severe TBI. Coupled with a structured training plan, the K99 phase will help Dr. Shen gain expertise in: (1) childhood TBI rehabilitation and outcome assessment, (2) technology-assisted childhood TBI rehabilitation, and (3) advanced design and analysis for RCTs in pediatric rehabilitation settings. Dr. Shen’s research and training during the K99 phase will be supported by the mentorship of an established and multidisciplinary team with extensive expertise in guiding trainees to successful academic careers as independent investigators, as well as the Inpatient Rehabilitation Unit and research core services at NCH. Along with the career development support from his Scholarship Oversight Committee, the K99 award will ensure Dr. Shen’s successful transition to the R00 phase as an independent tenure-track assistant professor in pediatric rehabilitation research. During the R00 phase, Dr. Shen will conduct a full-scale parallel-group RCT to formally evaluate the efficacy of the VR program on children’s core EFs, daily EFs, attention problems, and health-related quality-of-life outcomes. The expertise and skills gained from this K99/R00 award will inform the development of a comprehensive VR program for cognitive, emotional, and social rehabilitation among children with TBI and other acquired brain injuries.

Jiabin Shen博士是儿科创伤中心的研究科学家（博士后同等职位） 全国儿童医院研究所（NCH）。他的长期职业目标是 成为一名有成就的研究科学家，其研究重点是理论驱动， 儿童TBI的技术辅助心理康复。儿童TBI是导致 获得性残疾在美国儿童与700，000例，每年，这往往会导致重大损害 广泛的认知功能，特别是对儿童发展至关重要的执行功能（EF）， 特别是在患有中度至重度TBI的儿童中。尽管疾病控制和预防中心 (CDC)已经确定TBI后认知康复是TBI儿童最未满足的医疗保健需求， 专门为创伤性脑损伤后儿童EF康复设计的干预措施仍然不可用。虚拟现实 (VR)作为儿童TBI EF康复的替代策略，其灵活性提供了令人兴奋的潜力， 培训内容、可负担得起的远程访问能力，以及提高遵守率和技能转让的潜力。 然而，儿童TBI的VR为基础的EF康复的安全性/有效性仍有待确定。 这条通往独立的道路奖（K99/R 00）提案概述了结构化的职业发展， 研究计划旨在评估基于VR的创新EF培训计划的安全性和有效性， 患有中度至重度TBI的儿童。在K99阶段，沈博士将进行一个小型平行组 随机临床试验（RCT），以评估VR研究范式，安全性和初步疗效， 对30名7-17岁中重度TBI儿童进行干预。再加上结构化的培训计划， K99阶段将帮助沈医生获得以下方面专业知识：（1）儿童TBI康复和结果评估， (2)技术辅助的儿童TBI康复;（3）先进的RCT设计和分析， 儿科康复机构。沈博士在K99阶段的研究和培训将得到 一个成熟的多学科团队的指导，在指导学员方面具有广泛的专业知识， 成功的学术生涯作为独立的调查员，以及住院康复单位， 在NCH的研究核心服务。 沿着他的奖学金监督委员会的职业发展支持，K99奖将 确保沈博士成功过渡到R 00阶段，作为一个独立的终身助理教授， 儿科康复研究在R 00阶段，沈博士将进行一项全面的平行组RCT， 正式评估VR项目对儿童核心EF、日常EF、注意力问题的有效性， 健康相关的生活质量结果。从K99/R 00奖项中获得的专业知识和技能将为 为儿童的认知、情感和社会康复开发全面的VR计划 创伤性脑损伤和其他后天性脑损伤