UAB U-SPECT6CTUHROI Imager

本申请的广泛和长期目标是提供所提出的U- SPECT 6CTUHROI仪器到UAB研究基础设施进行同步 功能和解剖成像在广泛的生物和临床前应用。的 SPECT 6CTUHROI系统可通过超高分辨率获得精确的3D解剖信息 （4体素）计算机断层扫描（CT），与大量功能成像相结合 试剂（荧光，生物发光和/或放射性）在同一动物在同一时间， 提供了对生物应用的广泛适用性。共定位功能和解剖 信息提供了对疾病发病机理和治疗反应的上级理解， 加速研究进展，技术尚未提供给UAB社区。 因此，扫描仪为我们的研究创造了动物研究能力的范式转变 社区将促进纵向重复测量设计，提高再现性， 减少动物使用，并使组织水平的更详细的了解 发病机制这些设备将由NIH资助的一个大型团体使用， 跨多个疾病领域的合作研究者，包括呼吸和 环境疾病、肾脏疾病和微生物应用。多模态 该工具将被集成到一个高生产力和多学科的研究基础设施， 将改善对影响广泛患者的疾病的理解和治疗。 该仪器将由NIH支持的小动物成像设施管理，并与 由多学科呼吸成像核心，格雷戈里弗莱明詹姆斯 囊性纤维化研究中心和UAB-UCSD奥布莱恩急性肾损伤中心， 提供强大的用户基础，图像采集和分析方面的专业知识， 这些设施中的互补成像技术。强大和可持续 管理计划将确保以可持续的方式进入主要用户群及其他用户群。 该平台旨在促进具有重大影响的多学科研究。

The broad and long-term objectives of this application is to provide the proposed U- SPECT6CTUHROI instrumentation to the UAB research infrastructure to conduct simultaneous functional and anatomic imaging over a wide array of biological and preclinical applications. The SPECT6CTUHROI system allows for precise anatomic information in 3D by ultra-high resolution (4 voxel) computed tomography (CT) that is coupled with functional imaging with a large number of agents (fluorescent, bioluminescent, and/or radioactive) in the same animal at the same time, providing broad applicability to biological applications. Co-localized functional and anatomic information provides superior understanding of disease pathogenesis and therapeutic response, accelerating research progress, with techniques not yet available to the UAB community. Hence, the scanner creates a paradigm shift in animal research capabilities for our research community. Longitudinal repeated measure designs will be facilitated, improving reproducibility, reducing animal utilization, and empowering more detailed understanding of tissue-level pathogenesis. The equipment will be utilized by a large group of NIH-funded, established, and collaborative investigators spanning multiple disease areas, including respiratory and environmental diseases, kidney disease, and microbiological applications. The multi-modality tool will be integrated into a highly productive and multi-disciplinary research infrastructure, and will improve the understanding and treatment of disorders that affect a wide array of patients. The instrument will be managed by the NIH supported Small Animal Imaging Facility, and co- supported by the Multi-disciplinary Respiratory Imaging Core, the Gregory Fleming James Cystic Fibrosis Research Center, and the UAB-UCSD O'Brien Center for Acute Kidney Injury, providing a strong base of users, expertise in image acquisition and analysis, and several complementary imaging techniques housed in these facilities. The strong and sustainable management plan will assure access to the primary user base and beyond in a sustainable platform intended to foster multi-disciplinary research of substantial impact.