In Vivo Fluorescence and Bioluminescence Imager with CT

带 CT 的体内荧光和生物发光成像仪

• 批准号: 10177666
• 负责人: Rena Lapidus
• 金额: $ 60万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177666
• 关键词: 3-Dimensional; Animals; Baltimore; Bioluminescence; Communicable Diseases; Data; Disease; Dose; Fluorescence; Funding; Grant; Individual; Inflammation; Institution; Malignant Neoplasms; Maryland; Measures; Monitor; Mus; Nature; Neurobiology; Pathology; Research Personnel; Research Project Grants; Schools; Services; Structure; System; Three-Dimensional Imaging; Time; United States National Institutes of Health; Universities; Update; X-Ray Computed Tomography; bioluminescence imaging; drug development; experimental study; fluorescence imaging; imager; imaging capabilities; in vivo; in vivo imaging; in vivo imaging system; instrument; novel therapeutics; operation; tomography; tool

PROJECT SUMMARY Bioluminescent and fluorescent in vivo imaging on whole animal has become an increasingly important and necessary tool for biomedical researchers in many fields including cancer, neurobiology, infectious diseases and inflammation. In vivo imaging facilitates a better understanding of disease pathology, disease monitoring, and drug development. Perkin Elmer’s IVIS SpectrumCT measures bioluminescence, fluorescence, 2D and 3D imaging capabilities and included an integrated low-dose and ultra-fast CT imaging. Many of the research projects described in this application are translational in nature and will lead to new therapeutics or better understanding of disease states. Our current system purchased in 2005 and updated in 2012 and has become unreliable leading to significant downtime of the instrument. Many of our investigator who conduct longitudinal mice experiments have lost time, money, data and effort due to unexpected unavailability of our current IVIS Xenogen. We have nearly 55 users of the existing system from schools within the University of Maryland Baltimore (UMB) and various centers of excellence. We have identified a group of 20 NIH-funded investigators with 36 NIH and other federal grants whose individual projects would be directly and substantially benefitted by having continued access to a reliable, state-of-the-art instrument to conduct bioluminescence and fluorescence imaging in whole animals. Significant commitment by the institution towards installation and sustained long-term operations has been made in order obtain the state-of-the- art bioluminescence/fluorescence system with a built-in CT system for 3D tomography applications. The management and operational structure for this instrument is already in place with an outstanding technical team that strives to provide excellent service to the end users.

项目摘要 对整个动物的生物发光和荧光体内成像已经成为一种新的方法。 越来越重要和必要的工具，生物医学研究人员在许多领域，包括 癌症、神经生物学、传染病和炎症。体内成像有助于更好地 了解疾病病理学、疾病监测和药物开发。珀金埃尔默 IVIS SpectrumCT测量生物发光、荧光、2D和3D成像能力 并包括集成的低剂量和超快速CT成像。许多研究项目 在本申请中描述的是翻译性质的，并且将导致新的治疗剂或 更好地了解疾病状态。我们目前的系统于2005年购买， 2012年，并且变得不可靠，导致仪器的大量停机时间。我们的许多 进行纵向小鼠实验研究人员已经损失了时间、金钱、数据和精力 因为我们目前的IVIS Xenogen无法使用我们有近55名用户 来自马里兰州巴尔的摩大学（UMB）和各个学校的现有系统 卓越中心。我们已经确定了一个由20名NIH资助的研究人员组成的小组， 和其他联邦拨款，其个别项目将直接和实质性受益 通过持续使用可靠的、最先进的仪器来进行生物发光， 和荧光成像。机构对以下方面的重大承诺： 安装和持续的长期运作，以获得国家的- 用于3D断层扫描的内置CT系统的生物发光/荧光系统 应用.该工具的管理和业务结构已经到位 拥有一支优秀的技术团队，致力于为最终用户提供优质的服务。