ShEEP Request for an X-Ray Irradiation System

ShEEP 请求 X 射线辐照系统

• 批准号: 10177392
• 负责人: David Wald
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177392
• 关键词: 2019-nCoV; American; Anesthesia procedures; Animals; Area; Bacteria; Biological; Biology; Bone Marrow Transplantation; COVID-19; Cell Culture Techniques; Cells; Ceramics; Cesium; Collaborations; Collimator; Devices; Diagnostic radiologic examination; Disease Progression; Dose; Ensure; Environment; Equipment; Fostering; Funding; Health; Hematopoiesis; Homologous Transplantation; Human; Image; Imaging Device; Immune response; Individual; Isoflurane; Lead; Location; Longevity; Maintenance; Malignant Neoplasms; Medical center; Metals; Minor; Modeling; Multimodal Imaging; Mus; Mutation; Neurologic; Output; Play; Radiation Dose Unit; Radiation exposure; Radioactive; Reagent; Records; Research; Research Personnel; Roentgen Rays; Role; SARS-CoV-2 infection; Safety; Sampling; Security; Sheep; Site; Specimen; Sterility; Supervision; System; Technology; Time; Time Factors; Training; Transplantation; Tube; Veterans; Virus; Work; animal facility; animal imaging; anticancer research; base; cancer therapy; cost; design; high efficiency particulate air filter; image guided radiation therapy; imaging system; instrument; irradiation; neoplastic cell; nervous system disorder; programs; radiation effect; research study; touchpad; waiver; x-ray irradiation

The requested equipment is an X-RAD 320 large chamber self-contained X-ray system from Precision X-ray Inc. This equipment would significantly advance the existing research of a large number of VA researchers, enable the extension of current studies in new directions and foster collaborations among multiple VA investigators. The irradiator has built in functionality to perform both X-ray irradiation as well as bioluminescent imaging of small animals. There is currently no equipment at the Cleveland VA Medical Center to perform irradiation of any sort for research studies or bioluminescent imaging of small animals. This instrument will play a major role in enabling VA research to be performed on site at the Cleveland VA Medical Center that currently is not feasible and can only be performed off site. Acquisition of the irradiator will greatly enhance Cleveland VA research efforts in a variety of fields including cancer research, neurological research and studies on SARS-COV2. In addition to being the only instrument that incorporates imaging and irradiation into a single device, a major advantage of this instrument is its safety. Unlike radioactive irradiators that have major safety and regulatory concerns, this X-ray based instrument is safe and reliable. The Cleveland VA research program has 4 Major and several minor users whose research will be significantly impacted by this instrument. In addition, it is expected that the availability of this currently unavailable technology will help foster new directions for other local VA researchers. All of the users have strong track records of VA and other national funding that will help support the use of this machine. The PI will help lead the efforts to supervise and maintain the equipment as well as train other users. Overall, the purchase of the X-RAD 320 irradiator will fill a major unmet need for many VA researchers and facilitate future research efforts.

所要求的设备是X-RAD 320大型室式独立x射线系统