ShEEP Request for an X-Ray Irradiation System

ShEEP 请求 X 射线辐照系统

• 批准号: 10177392
• 负责人: David Wald
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177392
• 关键词: 2019-nCoV; American; Anesthesia procedures; Animals; Area; Bacteria; Biological; Biology; Bone Marrow Transplantation; COVID-19; Cell Culture Techniques; Cells; Ceramics; Cesium; Collaborations; Collimator; Devices; Diagnostic radiologic examination; Disease Progression; Dose; Ensure; Environment; Equipment; Fostering; Funding; Health; Hematopoiesis; Homologous Transplantation; Human; Image; Imaging Device; Immune response; Individual; Isoflurane; Lead; Location; Longevity; Maintenance; Malignant Neoplasms; Medical center; Metals; Minor; Modeling; Multimodal Imaging; Mus; Mutation; Neurologic; Output; Play; Radiation Dose Unit; Radiation exposure; Radioactive; Reagent; Records; Research; Research Personnel; Roentgen Rays; Role; SARS-CoV-2 infection; Safety; Sampling; Security; Sheep; Site; Specimen; Sterility; Supervision; System; Technology; Time; Time Factors; Training; Transplantation; Tube; Veterans; Virus; Work; animal facility; animal imaging; anticancer research; base; cancer therapy; cost; design; high efficiency particulate air filter; image guided radiation therapy; imaging system; instrument; irradiation; neoplastic cell; nervous system disorder; programs; radiation effect; research study; touchpad; waiver; x-ray irradiation

The requested equipment is an X-RAD 320 large chamber self-contained X-ray system from Precision X-ray Inc. This equipment would significantly advance the existing research of a large number of VA researchers, enable the extension of current studies in new directions and foster collaborations among multiple VA investigators. The irradiator has built in functionality to perform both X-ray irradiation as well as bioluminescent imaging of small animals. There is currently no equipment at the Cleveland VA Medical Center to perform irradiation of any sort for research studies or bioluminescent imaging of small animals. This instrument will play a major role in enabling VA research to be performed on site at the Cleveland VA Medical Center that currently is not feasible and can only be performed off site. Acquisition of the irradiator will greatly enhance Cleveland VA research efforts in a variety of fields including cancer research, neurological research and studies on SARS-COV2. In addition to being the only instrument that incorporates imaging and irradiation into a single device, a major advantage of this instrument is its safety. Unlike radioactive irradiators that have major safety and regulatory concerns, this X-ray based instrument is safe and reliable. The Cleveland VA research program has 4 Major and several minor users whose research will be significantly impacted by this instrument. In addition, it is expected that the availability of this currently unavailable technology will help foster new directions for other local VA researchers. All of the users have strong track records of VA and other national funding that will help support the use of this machine. The PI will help lead the efforts to supervise and maintain the equipment as well as train other users. Overall, the purchase of the X-RAD 320 irradiator will fill a major unmet need for many VA researchers and facilitate future research efforts.

所要求的设备是一台X-RAD 320大腔体自给式X射线系统 这种设备将极大地推进现有的大型 退伍军人管理局研究人员的数量，使目前的研究能够在新的方向上扩展并促进 多名退伍军人管理局调查人员之间的合作。该辐照器具有内置的功能 对小动物进行X射线照射和生物发光成像。的确有 目前，克利夫兰退伍军人医疗中心没有任何设备可以进行任何类型的照射 小动物的研究或生物发光成像。这件乐器将演奏一首主旋律 在使退伍军人管理局研究能够在克利夫兰退伍军人医疗中心现场进行方面发挥的作用 目前是不可行的，只能在场外进行。收购辐照器将 大大加强克利夫兰退伍军人管理局在包括癌症在内的各种领域的研究工作 SARS-COV2的研究、神经学研究和研究。除了成为唯一一个 将成像和辐射集成到单个设备中的仪器，这是一个主要优势 这台仪器最重要的是它的安全性。与放射性辐射器不同的是，放射性辐射器具有重大的安全性和 监管方面的担忧，这种基于X射线的仪器是安全可靠的。克利夫兰退伍军人事务部 研究计划有4个主要用户和几个次要用户，他们的研究将具有重要意义 受到这一工具的影响。此外，预计目前这款产品的可用性 不可用的技术将有助于为其他当地退伍军人管理局的研究人员培养新的方向。所有的 用户在退伍军人管理局和其他国家资金方面有良好的记录，这将有助于支持 使用这台机器。PI将帮助领导监督和维护设备的工作，如 以及培训其他用户。总体而言，购买X-RAD 320辐照器将填补一个重大未满足的问题 需要许多退伍军人管理局的研究人员，并促进未来的研究工作。