Molecular Storage System (MoSS): Intelligent DNA Data Storage

分子存储系统（MoSS）：智能DNA数据存储在过去的几年里，包括Helixworks在内的几个小组已经展示了DNA存储系统。存储的信息从几兆字节稳步增加到几百兆字节。然而，目前基于亚磷酰胺化学的DNA合成技术被设计用于制造用于生物应用的无错误DNA。如今，合成DNA每核苷酸的成本为0.001美元，这使得DNA存储比磁带贵7个数量级。基于FET Open项目生成的结果？OligoArchive？（赠款协议863320），三个参与者（Helixworks技术有限公司，帝国理工学院科学技术和医学，和EURECOM）正在寻求采取OligoArchive的结果进一步，通过发展的MoSS？一种新的DNA存储系统，基于一种新的酶技术，用于大规模写入DNA（这项创新由JRC评估？的市场创造潜力指标框架，因为有一个？嗨？市场创造潜力）。在MoSS中，我们将研究新的酶促合成技术，通过利用使用DNA作为数据存储介质不需要精确，无错误的合成，可以大大降低DNA合成的成本。我们的联盟成员在结构生物学（特别是DNA结合蛋白），合成生物学和自动化（包括无细胞蛋白合成）的学术研究（Imperial，Eurecom）以及工业研究（Helixworks）中处于最前沿，追求新颖，可扩展的酶促合成技术，可以提供低成本，高通量的DNA存储写入路径。

Molecular Storage System (MoSS): Intelligent DNA Data Storage Several groups, including Helixworks, have demonstrated DNA storage systems over the last few years. The information stored has steadily increased from a few kilobytes to several hundred megabytes. However, current DNA synthesis techniques based on phosphonamidite chemistry are designed for manufacturing error-free DNA for biological applications. Today, synthetic DNA costs $0.001 per nucleotide, making DNA storage seven orders of magnitude more expensive than tape. Based on results generated from the FET Open project ?OligoArchive? (grant agreement 863320), three of the participants (Helixworks Technologies Limited, Imperial College of Science Technology and Medicine, and EURECOM) are seeking to take the OligoArchive results further, through the development of MoSS ? a new DNA storage system based on a novel enzymatic technique for writing DNA at scale (this innovation was assessed by the JRC?s Market Creation Potential indicator framework as having a ?High? level of market creation potential). In MoSS, we will investigate novel enzymatic synthesis techniques that can dramatically reduce cost of DNA synthesis by exploiting that using DNA as a data storage medium does not require precise, error-free synthesis. Our consortium members are at the forefront in both academic research (Imperial, Eurecom) in structural biology (especially DNA-binding proteins), synthetic biology, and automation (including cell-free protein synthesis), and industrial research (Helixworks) in pursuing novel, scalable, enzymatic synthesis techniques that can offer low-cost, high-throughput write path to DNA storage.