Development of Population Level Serotyping Technology and Antibody Profiling for Infectious Pathogens with focus on Influenza and SARS-CoV-2
Development of Population Level Serotyping Technology and Antibody Profiling for Infectious Pathogens with focus on Influenza and SARS-CoV-2
开发传染病病原体的人群水平血清分型技术和抗体分析，重点关注流感和 SARS-CoV-2
批准号：
10193123
负责人：
Eric Okerberg
金额：
$72.85万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-09-05 至 2022-02-28
关键词：
2019-nCoVAntibodiesAntigensAutoimmune DiseasesBar CodesBindingBiological AssayBiological ModelsCOVID-19COVID-19 pandemicCommunicable DiseasesDNADNA LibraryDNA analysisDNA sequencingDataDetectionDevelopmentDiseaseEpitopesExposure toFerretsGTP-Binding Protein alpha Subunits, GsGoalsGrantHumanImmobilizationImmunoglobulinsImmunologyInfluenzaInfluenza A Virus, H1N1 SubtypeInfluenza A virusLibrariesMethodsMonitorNucleotidesPatientsPeptide antibodiesPeptidesPhasePloidiesPopulationProteinsProteomeProteomicsPublishingSamplingSerologic testsSerologicalSerotypingSerumSmall Business Innovation Research GrantSpecific qualifier valueSpecificitySurfaceTechnologyTimeTranslatingVeterinary MedicineViralbasebiosecuritycostdigitaldrug discoveryepidemiology studyimprovedindividual patientnovelpandemic diseasepathogenpathogen exposureprospectiveresponsesingle moleculeusabilityuser-friendly
中文摘要
翻译
摘要
该提案的目标是重新利用为下一代开发的技术
蛋白质组学开发高度可扩展的传染性疾病数字血清分型技术
疾病分析，特别适用于流感和新冠肺炎。该方法是
广泛适用，并应大大提高成本，灵敏度，可用性，
人群水平的血清分型通量大大提高了传染病
监测和监视。
英文摘要
ABSTRACT
The goal of this proposal is to repurpose technology developed for Next-Gen
Proteomics to develop a highly-scalable digital serotyping technology for infectious
disease analysis, with particular application to influenza and Covid-19. The approach is
broadly applicable and should greatly improve upon cost, sensitivity, usability, and
throughput of population-level serotyping and greatly improve infectious disease
monitoring and surveillance.
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