The perception of odor blends and mixtures: Modulation, Inhibition and Enhancement of Olfactory Receptors alters perception of complex blends

对气味混合物和混合物的感知：嗅觉受体的调节、抑制和增强改变了对复杂混合物的感知

• 批准号: 10201117
• 负责人: Stuart J Firestein
• 金额: $ 20.25万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201117
• 关键词: 2019-nCoV; Academic Medical Centers; Anosmia; Appearance; Cells; Cessation of life; Cilia; Complex; Disease; Dysgeusia; Fever; Fixatives; Freezing; Hour; Human; Immune response; Infection; Microscopy; Neurologic Effect; Neurologic Symptoms; Nose; Pathology; Pathway interactions; Patients; Perception; Procedures; Recovery; Reporting; Respiratory Signs and Symptoms; Smell Perception; Stains; Surgeon; Symptoms; Techniques; Time; Tissue Sample; Tissues; Viral; Virus; Virus Diseases; comorbidity; experience; human tissue; hyposmia; interest; olfactory receptor; pandemic disease; respiratory; tissue degeneration; tissue preparation; vascular abnormality

PROJECT SUMMARY/ABSTRACT This application seeks to take advantage of a unique opportunity to obtain significant amounts of human nasal tissue form recent CV-19 positive post mortems. Working with the Columbia University Medical Center Pathology Department and an ENY surgeon tissue is being recovered from post mortem procedures performed within 24 hours of death. We currently have 20 tissue samples of OE (attached to cribiform plate) and OB, in fixative and refrigerated or flash frozen. At the outset of the pandemic spread of the virus there were initially anecdotal, but now well quantified, reports of sudden anosmia and dysgeusia (likely a result of the anosmia) appearing 2-4 days before onset of the documented respiratory and fever symptoms of CV19. Although not all cases of CV19 experience the anosmia, all anosmias eventually became positive for CV19. The sense of smell is reportedly recovered in all surviving patients but requires 4-6 weeks post infection, long after other viral symptoms have resolved. The appearance of anosmia in the absence of respiratory symptoms – both before and after the disease time course, is of special interest as it differs significantly from hyposmias experienced during other respiratory illnesses. We will utilize human post mortem tissue to investigate, with advanced microscopy techniques and tissue preparation, several possible causes for this mysterious anosmia – including cell loss, tissue degeneration, cilia loss, vascular abnormalities, immune response comorbidities, and direct viral infection.

项目摘要/摘要 该申请旨在利用独特的机会获得大量 人类鼻组织形成最近的CV-19阳性验尸。与哥伦比亚合作 大学医学中心病理学系和ENY外科医生正在恢复 从死后24小时内执行的验尸程序。我们目前有20个 OE的组织样品（附着在外骨板上）和OB，以固定和冷藏或闪光 冷冻。在病毒的大流行开始时，最初有轶事，但 现在已经量化了充分的量化，突然的厌食症和肿瘤症（可能是厌食的结果） 出现在记录的CV19呼吸道和发烧症状前2-4天。 尽管并非所有CV19案件都经历了厌氧，但所有的厌氧都最终变成了 CV19阳性。据报道，所有尚存的患者都恢复了嗅觉，但 感染后需要4-6周，在其他病毒症状解决后很长时间。这 在没有呼吸道症状的情况下出现厌食 疾病时间课程具有特别的兴趣 在其他呼吸系统疾病期间。我们将利用人类验尸组织调查， 使用先进的显微镜技术和组织制备，这几种可能的原因 神秘的厌食症 - 包括细胞丧失，组织变性，纤毛丧失，血管异常， 免疫反应合并症和直接病毒感染。