Administrative Core

摘要 行政核心的总体目标是确保及时有效地执行拟议工作 通过对项目及核心领导和研究人员的管理、协调和监督 并解决可能出现的任何冲突。行政核心将确保 对项目和核心B进行了优化，以实现以下目标：鉴定新的基因功能， 结核分枝杆菌的药物靶点和代谢反应及其与临床传播表型的相关性 分离株，开发结核病治疗传播阻断潜力的新测试，新的动物模型 结核病的气源性传播，允许对结核分枝杆菌和结核杆菌的遗传学进行实验性修改 气雾化液滴的特性，以及降低R0的新方法的考虑。

ABSTRACT The overall goal of the Administrative Core is to ensure timely and effective execution of proposed work through management, coordination and supervision of the Project and Core Leaders and research personnel and resolution of any conflicts that may arise. The Administrative Core will ensure that the interaction of the Projects and Core B are optimized so as to succeed in the following goals: identification of new gene functions, drug targets and metabolic responses in Mtb, correlation of these with the transmission phenotype of clinical isolates, development of new tests for a TB treatment's transmission-blocking potential, new animal models for aerogenic transmission of TB that allow experimental modification of the genetics of Mtb and the characteristics of aerosolized droplets, and consideration of new approaches to reduce R0.