Explorative studies of novel IgE ligands

项目摘要 大多数过敏反应是由免疫球蛋白E（IgE）抗体引起的，这些抗体对过敏原具有特异性， 引发由肥大细胞和嗜碱性粒细胞介导的强有力的炎症反应。IgE与高亲和力的 受体（FcεRI）在这些过敏效应细胞上表达，使其成为一种常见的中心相互作用， 不同的过敏原特异性反应抗IgE抗体（奥马珠单抗）目前用于治疗过敏性 哮喘和慢性特发性荨麻疹，证明了抑制IgE：FcεRI相互作用的可行性， 治疗益处。我们已经开发了多种方法来鉴定IgE的小分子配体， 并为进一步的研究确定了有希望的线索。在本提案中，我们将进一步调查这些线索， 探索生产用于IgE功能和抑制的新型探针的可能性。 !

Project Summary Most allergic reactions are caused by immunoglobulin E (IgE) antibodies that are specific for allergens and that trigger potent inflammatory responses mediated by mast cells and basophils. IgE binds to the high affinity receptor (FcεRI) expressed on these allergic effector cells, making this a central interaction that is common to different allergen-specific responses. The anti-IgE antibody (omalizumab) is currently used to treat allergic asthma and chronic idiopathic urticaria, demonstrating the feasibility of inhibiting the IgE:FcεRI interaction for therapeutic benefit. We have developed multiple approaches to identifying small molecule ligands for the IgE and identified promising leads for further studies. In this proposal, we will further investigate these leads to explore the possibility of producing novel probes for IgE function and inhibition. !