Mobile DNA activity in the mammalian primordial germline

在怀孕早期，胚胎中的少数细胞成为原始生殖细胞(PGCs)。这些PGC最终将产生精子或卵细胞，代表着关键的代际遗传联系。移动DNA序列以PGC为目标，创造新的可遗传的遗传变化。这项建议旨在分析PGC中移动DNA活动的活性、调节和后果。该项目期望产生关于哺乳动物遗传多样性起源的重要知识。预期成果包括加强跨学科和新的实验系统的国家和国际合作。预期的好处是加强对哺乳动物遗传多样性和疾病背后的突变过程的理解。

Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.