Digital Technology Core

数字技术核心

• 批准号: 10203780
• 负责人: Zachary Beattie
• 金额: $ 28.71万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10203780
• 关键词: Aging; Agitation; Alzheimer' s Disease; Alzheimer' s disease related dementia; Analgesics; Appointment; Area; Atrophic; Automobile Driving; Behavior; Biological Markers; Caregivers; Clinical; Clinical Markers; Clinical assessments; Cognition; Collaborations; Communities; Computers; Computing Methodologies; Data; Dementia; Devices; Diagnosis; Early Diagnosis; Elderly; Environment; Evolution; Fostering; Gait speed; Genetic; Home; Impaired cognition; Intervention; Investigation; Laboratories; Life; Liquid substance; Maps; Measurement; Measures; Medial; Methodology; Modeling; Monitor; Moods; Motor; Oregon; Outcome; Participant; Pathologic; Pathology; Patients; Pattern; Peer Review; Pharmaceutical Preparations; Phase; Physical activity; Physiology; Process; Protocols documentation; Psychometrics; Research; Research Personnel; Resources; Risk; Sampling; Sister; Sleep; Symptoms; Technology; Temporal Lobe; Testing; Time; Videoconferencing; Visit; advanced dementia; aging brain; care recipients; cognitive change; cohort; computational platform; dementia care; digital; experience; follow-up; improved; insight; interest; novel strategies; programs; sensor; social engagement; statistics; training opportunity; volunteer; white matter change

Project Summary: Digital Technology Core Given limitations of conventional clinical assessments to precisely map change trajectories, our research community increasingly seeks methodologies that incorporate continuous, real-world and objective measurement of key features (e.g., mobility, cognition, sleep, medication taking, driving) using the pervasive computing platform and methodologies of ORCATECH (Oregon Center for Aging & Technology). This new approach has important application in many areas of dementia research beyond early detection, such as caregiver/care recipient activities; agitation in institutional settings; and objective digital biomarkers (DB) of sleep, physical activity, and the environment. Use of these technologies is not limited to assessment, but may also deliver interventions, such as dementia care programs via home video. Given the growing use and promise of DB and related technologies, this proposal will consolidate and build upon recent advances through the Oregon Alzheimer’s Disease Research Center’s Digital Technology Core (DTC). Specific Aims are: 1. To maintain and make available for research, an OADRC dementia-specific focused Life Laboratory cohort of research volunteers (healthy controls, MCI, and AD) who will have deployed in their homes state-of-the-art sensing and pervasive computing platforms. 2. To obtain and make available for research, DB data on OADRC subjects. 3. To foster collaborative research involving DB and related technologies.

项目概要：数字技术核心 考虑到传统临床评估在精确绘制变化轨迹方面的局限性，我们的研究 社区越来越多地寻求将连续的、真实的和客观的 关键特征的测量（例如，移动性、认知、睡眠、服药、驾驶）， ORCATECH（俄勒冈州老龄化与技术中心）的计算平台和方法。这个新 这种方法在痴呆症研究的许多领域都有重要的应用，而不仅仅是早期发现，例如 护理人员/护理接受者活动;机构环境中的躁动;以及以下各项的客观数字生物标志物（DB）： 睡眠、身体活动和环境。这些技术的使用不仅限于评估， 还提供干预措施，例如通过家庭视频提供痴呆症护理计划。鉴于越来越多的使用和 DB和相关技术的承诺，这项建议将巩固和建立在最近的进展，通过 俄勒冈州阿尔茨海默病研究中心的数字技术核心（DTC）。具体目标是： 1.为了维持和提供研究，一个OADRC专门针对痴呆症的生命实验室 研究志愿者队列（健康对照、MCI和AD），他们将在家中部署 最先进的传感和普及计算平台。 2.获取并提供OADRC受试者的DB数据用于研究。 3.促进涉及数据库和相关技术的合作研究。