CONTROL-CORE: A Modular Simulation Environment for Design and Prototyping of Closed-loop Peripheral Neuromodulation Control Systems using the O2S2PARC Platform

该方案的总体目标是开发一个名为 用于电子实验的控制核心，包括设计、分析、原型制作、部署 以及执行用于外围设备的闭环刺激的反馈控制体系结构 神经系统。为了推进这一目标，我们将使用现有的心脏数据和模型 和胃肠道(GI)系统，并利用O？S？帕洛阿尔托实验室平台 所提出的控制核心仿真平台的基本构建块。两个人 选定的系统以两种方式涵盖了SPARC相关器官的两个极端：(1)非常慢 (GI系统)到非常快(心脏)的时间尺度；和(2)完全数据驱动(GI系统)到非常详细 机械(心脏)模型由于对这些器官的基本了解程度不同。 这将使我们能够开发可能适用于其他SPARC相关的工具 介于这两个极端之间的器官/功能。我们将使用集装箱和工作流 管理服务创建模块化算法库，以确保重现性。 控制核心将是成功部署电动闭环系统的核心 未来1-4年的神经调节疗法，使实验者、模型师和 使设备开发人员能够在统一的框架中协同工作并共享成果。特别是， 利用闭合外周开发个性化治疗的体内研究规划 提供的电子测试能力将极大地促进神经调节策略的实施 由控制核心控制。为此，将执行的主要任务包括： 任务1-开发控制核心算法库以实现模块化构建， 闭环式神经调节控制结构的仿真与原型。我们将发展 基于数据驱动模型(GI)和机械模型的闭环控制算法 (心脏的)器官系统的。 任务2--为集装箱运输开发控制核心软件和服务 算法和模型，以及容器的编排，以构建和制作闭合环的原型 控制管道，并与O2S2PARC平台无缝集成。 任务3-将控制核心与O2S2PARC平台集成并验证闭环系统 在O2S2PARC中使用心脏力学模型和GI数据驱动模型进行模拟。 验证后，我们将准备文件并传播工具和程序。 我们将采用迭代设计和开发流程，以确保与 O2S2PARC平台。该项目的主要成果包括： (1)包含至少一个GI数据驱动模型和一个机械/混合灰箱 适用于O2S2PARC内控制器测试的心脏系统模型。 (2)至少一种将测量输出连接到刺激输入的闭环控制算法 用于胃肠道系统，以及用于O2S2PARC以外的心脏系统。 (3)确定SIM-CORE兼容所需技术能力的计划 用于模拟具有闭环系统的管道系统的控制核心。 (4)至少一个模型和一个控制器的实施，在闭环、集装箱化和 部署在O2S2PARC平台上。 (5)针对每个说明性案例演示仿真的闭环控制系统--GI O2S2PARC内的系统和心脏系统。

The overarching objective of this proposal is to develop a virtual simulation environment called CONTROL-CORE for in silico experimentation with the design, analysis, prototyping, deployment and execution of feedback control architectures for closed-loop stimulation of the peripheral nervous system. To advance this goal, we will use existing data and models in the cardiac and gastrointestinal (GI) systems and leverage the O²S²PARC platform to demonstrate the basic building blocks for the proposed CONTROL-CORE simulation platform. The two chosen systems cover the two extremes of SPARC-relevant organs in two ways: (1) very slow (GI system) to very fast (cardiac) time scales; and (2) fully data-driven (GI system) to very detailed mechanistic (cardiac) models due to the different levels of basic understanding of these organs. This will allow us to develop tools that are likely to be applicable to other SPARC-relevant organs/functions that lie between these two extremes. We will use containerization and workflow management services to create modular algorithm libraries to ensure reproducibility. CONTROL-CORE will be central to the successful deployment of electroceutical closed-loop neuromodulation therapies in the next 1-4 years by enabling experimentalists, modelers and device developers to work in concert and share results in a unified framework. In particular, planning of in vivo studies for developing personalizable therapies using closed-loop peripheral neuromodulation strategies will be greatly facilitated by the in silico testing capabilities provided by CONTROL-CORE. To this end, the major tasks to be performed include: Task 1- Develop the CONTROL-CORE algorithm libraries to enable modular construction, simulation and prototyping of closed-loop neuromodulation control architectures. We will develop closed-loop control algorithms based on data-driven models (GI) and mechanistic models (cardiac) of the organ system. Task 2- Develop the CONTROL-CORE software and services for containerization of the algorithms and models, and orchestration of the containers to construct and prototype closed-loop control pipelines and seamless integration with the O2S2PARC platform. Task 3- Integrate CONTROL-CORE with the O2S2PARC platform and validate closed-loop simulation in the O2S2PARC using the cardiac mechanistic models and the GI data-driven models. After validation, we will prepare documentations and disseminate the tools and procedures. We will employ an iterative design and development process to ensure compatibility with the O2S2PARC platform. The major deliverables of the project include: (1) Incorporation of at least one data driven model for GI and one mechanistic/mixed grey-box model for cardiac system in a format suitable for controller testing within O2S2PARC. (2) At least one closed-loop control algorithm connecting measured output to stimulation input for the GI system and one for the cardiac system outside of O2S2PARC. (3) A plan to identify required technical capabilities for SIM-CORE to be compatible with CONTROL-CORE for simulating pipeline systems with closed-loops. (4) Implementation of at least one model and one controller, in closed-loop, containerized and deployed in the O2S2PARC platform. (5) Closed-loop control system demonstrating simulations for each expository case -- the GI system and the cardiac system within O2S2PARC.