Carolina Center on Alzheimer's Disease and Minority Research (CCADMR)

整体剖面 项目概要/摘要 由于其巨大的人力和经济负担，阿尔茨海默病和相关痴呆症 （ADRD）已上升到美国（U.S.）公共卫生议程的最前沿。年长的 非裔美国人患 ADRD 的可能性增加。南卡罗来纳州有 美国 ADRD 的年龄调整死亡率最高 更好地了解 ADRD 的作用 社会文化、行为和环境决定因素对ADRD结果的影响 东南部的非裔美国人社区迫切需要。的 拟议的卡罗莱纳州阿尔茨海默病和少数族裔研究中心的总体目标 (CCADMR) 旨在增加专注于人口健康的研究队伍的多样性 通过持续的基础设施来支持 ADRD 差异的决定因素 代表性不足和少数族裔 (URM) 教员专注于少数族裔的健康和福祉 长老们。拟议 AD-RCMAR 的具体目标是： (1) 增加 URM 的容量 学者们致力于推动社会文化、行为和环境因素的科学发展 影响 ADRD 结果，以减少 ADRD 相关差异，重点关注非洲 美国人，以及 (2) 推进 ADRD 研究的科学性，重点关注人口健康和 通过以人口为基础的中等教育的研究教育来确定ADRD差异的决定因素 数据分析、跨学科联合指导团队、完善的招聘策略 AD-RCMAR 科学家，以及健康差异和少数民族老龄化研究教育。的 拟议的 CCADMR 是一项全州范围的合作，提供以下方面的指导和教育： 使用 URM 教师基于人口的数据集来确定 ADRD 差异的决定因素 南卡罗来纳州，在三大研究机构，包括南卡罗来纳大学 （UofSC）、南卡罗来纳医科大学（MUSC）和克莱姆森大学（CU），以及三所 传统黑人学院和大学 (HBCU)，包括艾伦大学、克拉夫林大学 大学和南卡罗来纳州立大学。跨学科和合作伙伴参与的研究， 主要研究者 (PI) 和研究团队拥有专业知识，将成为 解决 ADRD 相关差异的有效策略。拟议的中心利用 多个 PI 在为 URM 提供老龄化和 ADRD 关键培训方面发挥了广泛的领导作用 科学家及其在认知衰老、少数族裔健康和 ADRD 差异方面的研究专业知识。 PI 和核心领导者都是知名的协作学者，拥有大量的研究成果。 指导经验和内容知识将有助于拟议的成功 CCADMR。

OVERALL SECTION PROJECT SUMMARY/ABSTRACT Due to its tremendous human and financial burden, Alzheimer’s disease and related dementias (ADRD) have risen to the forefront of the United States (U.S.) public health agenda. Older African Americans are at an increased likelihood of having ADRD. South Carolina has the highest age-adjusted death rate from ADRD in the U.S. A better understanding of the role that sociocultural, behavioral, and environmental determinants have on ADRD outcomes among African-American communities in the Southeast is critically and immediately needed. The overall goal of the proposed Carolina Center on Alzheimer’s Disease and Minority Research (CCADMR) is to increase the diversity of the research workforce focused on population health and determinants of ADRD disparities through sustained infrastructure that will support underrepresented and minority (URM) faculty focused on the health and well-being of minority elders. The Specific Aims of the proposed AD-RCMAR are to: (1) increase the capacity of URM scholars to advance the science on the sociocultural, behavioral, and environmental factors that influence ADRD outcomes in order to reduce ADRD-related disparities, with a focus on African Americans, and (2) advance the science of ADRD research focused on population health and determinants of ADRD disparities through research education in population-based, secondary data analysis, interdisciplinary co-mentoring teams, well-established strategies for recruitment of AD-RCMAR Scientists, and education on Health Disparities and Minority Aging Research. The proposed CCADMR is a state-wide collaboration, providing mentorship and education on determinants of ADRD disparities using population-based datasets for URM faculty throughout South Carolina, at the three major research institutions, including University of South Carolina (UofSC), Medical University of South Carolina (MUSC), and Clemson University (CU), and three Historically Black Colleges and Universities (HBCUs), including Allen University, Claflin University, and South Carolina State University. Interdisciplinary and partner-engaged research, with which the principal investigators (PIs) and research team have expertise, will be an effective strategy for addressing ADRD-related disparities. The proposed Center leverages the multiple PIs’ extensive leadership in providing critical training in aging and ADRD for URM Scientists and their research expertise in cognitive aging, minority health, and ADRD disparities. The PIs and Core Leads are well-established and collaborative scholars with substantial mentoring experience and content knowledge that will contribute to the success of the proposed CCADMR.