Carolina Center on Alzheimer's Disease and Minority Research (CCADMR)

整个截面 项目概要/摘要 由于其巨大的人力和财政负担，阿尔茨海默病和相关的痴呆症 （ADRD）已经上升到美国（美国）的最前沿。公共卫生议程。老年 非裔美国人患ADRD的可能性增加。南卡罗来纳州有 美国ADRD的年龄调整死亡率最高。 社会文化，行为和环境决定因素对ADRD结果的影响， 东南部的非洲裔美国人社区是迫切需要的。的 拟议中的卡罗莱纳老年痴呆症和少数民族研究中心的总体目标 （CCADMR）的目标是增加以人口健康为重点的研究队伍的多样性 和决定因素的ADRD差距通过持续的基础设施，将支持 代表性不足和少数民族（URM）的教师专注于少数民族的健康和福祉 长老拟议的AD-RCMAR的具体目标是：（1）增加URM的容量 学者推动科学的社会文化，行为和环境因素， * 影响防治荒漠化和农村发展成果，以减少与防治荒漠化和农村发展有关的差距，重点是非洲 美国人，（2）推进ADRD研究的科学，重点是人口健康， 通过在以人口为基础的中等教育中开展研究教育， 数据分析，跨学科的共同指导团队，完善的招聘战略， AD-RCMAR科学家，健康差异和少数民族老龄化研究教育。的 拟议的CCADMR是一个全州范围的合作，提供指导和教育， ADRD差异的决定因素，使用基于人口的数据集为URM教师在整个 南卡罗来纳州，在三大研究机构，包括南卡罗来纳州大学 （UofSC）、南卡罗来纳州医科大学（MUSC）和克莱姆森大学（CU），以及三所 历史上的黑人学院和大学（HBCUs），包括艾伦大学，克拉夫林 大学和南卡罗来纳州州立大学。跨学科和合作伙伴参与的研究， 主要研究者（PI）和研究团队拥有专业知识，将是一个 有效战略，以解决与ADRD有关的差异。拟议的中心利用 多个PI在为URM提供老龄化和ADRD关键培训方面的广泛领导力 科学家和他们在认知老化，少数民族健康和ADRD差异方面的研究专长。 PI和核心领导是信誉卓著的合作学者， 指导经验和内容知识，这将有助于成功的建议 CCADMR。

OVERALL SECTION PROJECT SUMMARY/ABSTRACT Due to its tremendous human and financial burden, Alzheimer’s disease and related dementias (ADRD) have risen to the forefront of the United States (U.S.) public health agenda. Older African Americans are at an increased likelihood of having ADRD. South Carolina has the highest age-adjusted death rate from ADRD in the U.S. A better understanding of the role that sociocultural, behavioral, and environmental determinants have on ADRD outcomes among African-American communities in the Southeast is critically and immediately needed. The overall goal of the proposed Carolina Center on Alzheimer’s Disease and Minority Research (CCADMR) is to increase the diversity of the research workforce focused on population health and determinants of ADRD disparities through sustained infrastructure that will support underrepresented and minority (URM) faculty focused on the health and well-being of minority elders. The Specific Aims of the proposed AD-RCMAR are to: (1) increase the capacity of URM scholars to advance the science on the sociocultural, behavioral, and environmental factors that influence ADRD outcomes in order to reduce ADRD-related disparities, with a focus on African Americans, and (2) advance the science of ADRD research focused on population health and determinants of ADRD disparities through research education in population-based, secondary data analysis, interdisciplinary co-mentoring teams, well-established strategies for recruitment of AD-RCMAR Scientists, and education on Health Disparities and Minority Aging Research. The proposed CCADMR is a state-wide collaboration, providing mentorship and education on determinants of ADRD disparities using population-based datasets for URM faculty throughout South Carolina, at the three major research institutions, including University of South Carolina (UofSC), Medical University of South Carolina (MUSC), and Clemson University (CU), and three Historically Black Colleges and Universities (HBCUs), including Allen University, Claflin University, and South Carolina State University. Interdisciplinary and partner-engaged research, with which the principal investigators (PIs) and research team have expertise, will be an effective strategy for addressing ADRD-related disparities. The proposed Center leverages the multiple PIs’ extensive leadership in providing critical training in aging and ADRD for URM Scientists and their research expertise in cognitive aging, minority health, and ADRD disparities. The PIs and Core Leads are well-established and collaborative scholars with substantial mentoring experience and content knowledge that will contribute to the success of the proposed CCADMR.