Biomarkers of Binge Drinking in Maltreated Adolescents

项目摘要 在目前的R15应用中，我们提出了一个基于家庭的纵向研究的关键延续，旨在 鉴定与重度间歇性饮酒（HED;即， 酗酒）与对照组相比。第一阶段从12到14岁的孩子开始 来捕捉HED行为的开始。第二阶段将跟踪17至19岁青少年的发展， 这在第一阶段是不可能的，因为年轻人太年轻了。第二阶段扩展了 对受虐待青少年进行了一项成功的、纵向的、以家庭为基础的脑电图（EEG）研究（N=61，98%）， 前三年的保留）。整个样本（CM和匹配的对照青年）从部门招募 社会服务，以最大限度地匹配邻里，社会经济地位，种族和其他因素。每个 参加者有3次年度评估。在第二阶段，我们将扩大样本量（从60人增加到120人）， 继续随访所有现有参与者，每年进行3次家庭EEG、CM、表型、行为， 对12-19岁儿童进行认知、情感和物质使用评估。这将产生总共582项研究 访视，其将被把握度检测与CM和脑功能相关的HED发作和峰值。在第二阶段， 大多数样本将在青春期后期，当HED行为达到高峰时;因此，我们预计HED的发生率会更高。 基于任务的EEG和额叶EEG不对称（EA）是新的焦点，因为它们与方法有关- 避免网络与青少年，成人和跨物种的创伤和酒精使用相关。具有6 多年的数据，包括发病和高峰期HED发展时期是至关重要的，以确定长期模式， 可能成为预防和干预工作目标的机制。本科生和研究生将 从事第二阶段的所有方面，包括荣誉论文，硕士论文和博士论文。 有许多研究措施尚未进行评估或需要额外的年龄数据建议 在第二阶段检查弹道因此，该项目的第二阶段将继续直接让学生参与 神经科学和酒精使用研究的各个层面。它还将包括新的神经科学，旨在 了解受虐待青少年中HED的风险和机制。

PROJECT SUMMARY In the current R15 application, we propose a critical continuation of a home-based, longitudinal study aimed at identifying neurodevelopmental pathways associated with risk and resilience to heavy episodic drinking (HED; i.e., binge drinking) in maltreated adolescents compared to matched controls. Phase I began with 12- to 14-year-olds to capture onset of HED behaviors. Phase II will follow youth developmentally up to age 17- to 19-year-olds to capture peak use, which was not possible in Phase I because youth were too young. Phase II extends a successful, longitudinal, home-based, electroencephalogram (EEG) study of maltreated adolescents (N=61, 98% retention in first 3 years). The entire sample (both CM and matched control youth) was recruited from Department of Social Services to maximize matching of neighborhood, socioeconomic status, ethnicity and other factors. Each participant has had 3 annual assessments. With Phase II, we will expand the sample size (from 60 to 120) and will continue to follow all existing participants with 3 more annual home-based EEG, CM, phenotypic, behavioral, cognitive, affective, and substance use assessments for ages 12-19 years. This will yield a total of 582 study visits, which will be powered do detect onset and peak HED in relation to CM and brain function. In Phase II, the majority of sample will be in late adolescence, when HED behaviors peak; so, we expect higher rates of HED. Task-based EEG and frontal EEG asymmetry (EA) are new foci because they have been linked to the approach- avoidance networks associated with trauma and alcohol use in adolescents, adults, and across species. Having 6 years of data that include onset and peak HED developmental period is vital for identifying long-term patterns and mechanisms that may be targets in prevention and intervention efforts. Undergraduate and graduate students will be engaged all aspects of Phase II including with honors theses, master’s theses, and doctoral dissertations. There are numerous study measures that have not yet been evaluated or require the additional age data proposed in Phase II to examine trajectories. Therefore, Phase II of this project will continue to directly engage students in neuroscience and alcohol use research at every level. It will also include novel neuroscience aimed at understanding risks and mechanisms for HED in maltreated adolescents.