Administrative Core

行政核心

• 批准号: 10232834
• 负责人: Edward M. Schwarz
• 金额: $ 27.7万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10232834
• 关键词: Academic Medical Centers; Award; Basic Science; Biochemistry; Biocompatible Materials; Biology; Biomechanics; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Country; Custom; Data Science; Department chair; Direct Costs; Elements; Endowment; Ensure; Exercise; Faculty; Feedback; Fostering; Funding; Goals; Grant; Growth; Histology; Human Subject Research; Institutes; International; Investments; Leadership; Letters; Malignant Neoplasms; Mentors; Mission; Monitor; Multimodal Imaging; Muscle; Musculoskeletal; Names; Orthopedics; Productivity; Publications; RNA; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; Role; Running; Series; Services; Strategic Planning; Structure; Tissue imaging; Translating; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Visit; Work; academic program; base; big-data science; bone; clinical application; clinical translation; collaborative environment; cost effective; design; high standard; innovation; laboratory facility; meetings; mid-career faculty; molecular imaging; multimodality; nutrition; outreach; population health; professor; programs; ranpirnase; recruit; response; success; surgery outcome; symposium; tenure track

Abstract The Administrative Core will run the Enrichment Program, and will coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, Biomaterials and Multimodal Tissue Imaging (B2MTI) Cores, in order to ensure progress of the Rochester Resource- based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) in an efficient manner. The Core Users Committees, the URMC Shared Resource Laboratories & Facilities, and meeting structure of the Administrative Core are key elements that organize the communication and collaboration among the ROCSTARR investigators, as well as with other faculty in the Center for Musculoskeletal Research (CMSR) and collaborating Departments and Centers within the University. The activities of the Co-Directors, Mentors, Advisors, and staff in the Administrative Core will be tightly monitored by the Core Users Committee, which is made up of junior to mid-career faculty and trainees, and was established in our 2019 Center for Musculoskeletal Research (CMSR) 5-year Strategic Plan to provide direct feedback. These activities, which will be formally reviewed weekly by the Co-Directors, are embodied by the following Specific Aims. 1) To maintain state-of-the-art resource-based Cores for basic science, translational and clinical bone, muscle & orthopaedic research; and utilize these resources in a cost-effective manner to accelerate the pace of discovery and clinical translation. 2) To continue to foster our highly collaborative environment that translates basic research into clinical trials, and to expand our outreach activities with a new focus on underrepresented minorities, to promote the use of the resources offered by the P30 Core to new external collaborations that will grow our musculoskeletal research base at URMC, nationally and internationally. 3) To grow our Pilot Grant Program from $100,000 to $130,000 per year with a new parallel Discovery Fund, with which the Mentoring Core will expeditiously allocate small grants up to $5,000. We will also enhance our Enrichment Programs beyond these Pilot Grants, the William F. Neuman Visiting Professor series, and Annual Musculoskeletal Research Symposium, by expanding the community and promoting innovative research in bone, muscle and orthopaedic research. 4) To maintain our Clinical-Translational Sub- Core that administers human subject research services leveraging and customizing resources from the Clinical-Translational Science Institute, to enhance the translation of musculoskeletal basic science to clinical application, and grow collaborative networks with a new emphasis on Big Data science, surgical outcomes and population health research. And, 5) To expand our highly successful Mentoring Program, which facilitates the advancement of our New/Early Stage Investigators to NIH R01 funded PIs and national leadership status, and implements the highest standards of scientific rigor in response to NIH’s plan to enhance reproducibility. Execution of these aims will accelerate and enhance the productivity and establishment of the musculoskeletal research work force at URMC and beyond.

摘要 行政核心将运行浓缩计划，并将协调和整合 组织学、生物化学和分子成像(HBMI)与生物力学、生物材料和 多模式组织成像(B2MTI)核心，以确保罗切斯特资源的进展- 以骨、肌肉和整形外科研究中心(ROCSTARR)为基地，以高效的方式。 核心用户委员会、城市资源中心共享资源实验室和设施以及会议 行政核心的结构是组织沟通和 ROCSTARR调查人员之间的合作，以及与该中心的其他教员的合作 肌肉骨骼研究(CMSR)和大学内的合作部门和中心。 行政核心中的联席主任、导师、顾问和工作人员的活动将密切相关 由职业生涯初级至中期教员和实习生组成的核心用户委员会进行监测， 并在我们的2019年肌肉骨骼研究中心(CMSR)五年战略计划中成立，以 提供直接反馈。这些活动将由联合主任每周正式审查， 具体目标有以下几点。1)维护最先进的基于资源的核心 基础科学、翻译和临床骨、肌肉和骨科研究；并利用这些 资源，以经济高效的方式加快发现和临床翻译的步伐。2)至 继续促进我们高度协作的环境，将基础研究转化为临床试验， 并扩大我们的外展活动，把新的重点放在代表性不足的少数族裔身上，以促进 将P30 Core提供的资源用于新的外部协作，这将使我们的 在国内和国际上的URMC肌肉骨骼研究基地。3)增加我们的试点补助金 计划从每年100,000美元增加到130,000美元，并设立了一个新的并行发现基金， 指导核心将迅速分配高达5,000美元的小额赠款。我们还将加强我们的 这些试点助学金之外的丰富计划，威廉·F·诺伊曼客座教授系列，以及 一年一度的肌肉骨骼研究研讨会，通过扩大社区和促进创新 骨骼、肌肉和骨科研究。4)维护我们的临床-翻译子- 管理人类主题研究服务的核心，利用和定制来自 临床-翻译科学研究所，加强肌肉骨骼基础科学的翻译 临床应用，并发展协作网络，新的重点是大数据科学、外科 结果和人口健康研究。以及，5)扩大我们非常成功的指导 计划，这有助于我们的新/早期调查人员进入NIH R01资助的 PIS和国家领导地位，并实施最高标准的科学严谨应对 美国国立卫生研究院提高再生性的计划。执行这些目标将加速和加强 URMC及其他机构的生产力和肌肉骨骼研究工作队伍的建立。