Biostatistics Core

生物统计学核心

• 批准号: 10222603
• 负责人: Peng Huang
• 金额: $ 25.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-18 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222603
• 关键词: Address; Animals; Basic Science; Bioinformatics; Biological; Biometry; Biostatistics Core; Cancer Biology; Clinical Sciences; Collaborations; Consultations; Custom; Data; Data Analyses; Data Discovery; Data Storage and Retrieval; Detection; Development; Ensure; Equipment; Faculty; Funding; Genome; Genomics; Goals; Human; Immunologics; Information Storage; K-Series Research Career Programs; Laboratory Finding; Learning; Malignant Neoplasms; Malignant neoplasm of ovary; Manuscripts; Methodology; Modeling; Monitor; Morbidity - disease rate; Morphologic artifacts; Oncology; Positioning Attribute; Publications; Quality Control; Recording of previous events; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Running; Services; Techniques; Technology; Testing; Visualization; Work; Writing; base; cancer genetics; cancer genomics; cancer prevention; cancer therapy; data acquisition; design; genomic data; in vivo; innovation; interest; member; mortality; multidimensional data; personalized medicine; programs; stem; synergism; therapeutic target; tool

BIOSTATISTICS CORE: PROJECT SUMMARY The Biostatistics Core Resource will provide comprehensive biostatistics and bioinformatics consultation and collaboration to all Research Projects in the proposed Johns Hopkins Ovarian Cancer SPORE. Core members will work with project investigators across a wide spectrum of activities, encompassing data acquisition (including study design, feasibility of objectives, availability of public-access genomic information, and data storage), statistical quality control (including artifact detection and preprocessing of data from genomic technologies), data analysis (including visualization, biostatistical modeling, and assistance with manuscript writing), and development of innovative customized biostatistical methodologies and tools if required by specific projects. The proposed Ovarian Cancer SPORE Biostatistics Core is housed in the Division of Oncology Biostatistics and Bioinformatics of the Department of Oncology, an active and committed group of biostatistics and bioinformatics faculty members, with access to state-of-the art equipment and a broad range of expertise. This Core resource builds on expertise gained by Core members who actively participate in other SPOREs at Johns Hopkins. Core members have a strong commitment to this SPORE, stemming from: a) a history of collaboration with the investigators on this other research projects in ovarian cancer, b) an active and independently funded agenda of synergistic projects in cancer genetics and genomics, and c) a demonstrated interest and understanding of both the biological and analytical questions and challenges. All proposed Projects are anticipated to make use of this Resource.

生物统计学核心：项目摘要 生物统计核心资源将提供全面的生物统计和生物信息学咨询以及 与约翰霍普金斯提议的卵巢癌孢子的所有研究项目合作。核心成员 将在广泛的活动范围内与项目调查人员合作，包括数据获取(包括 研究设计、目标的可行性、可供公众获取的基因组信息和数据存储)， 统计质量控制(包括人工产物检测和来自基因组技术的数据的预处理)、数据 分析(包括可视化、生物统计建模和协助手稿写作)，以及 如果具体项目需要，开发创新的定制生物统计方法和工具。这个 拟议的卵巢癌孢子生物统计核心设在肿瘤学生物统计和 肿瘤学系的生物信息学，一个积极和致力于生物统计和生物信息学的团体 拥有先进的设备和广泛的专业知识的教职员工。此核心资源 建立在约翰霍普金斯大学积极参与其他孢子活动的核心成员所获得的专业知识的基础上。堆芯 成员对这一孢子有着坚定的承诺，源于：a)与 这一卵巢癌其他研究项目的调查人员，b)积极和独立资助的议程 癌症遗传学和基因组学方面的协同项目，以及c)对两者都表现出兴趣和理解 生物学和分析方面的问题和挑战。所有拟议的项目预计都将利用这一点 资源。