Molecular Pathogenesis of the Hamartoma Syndromes

错构瘤综合征的分子发病机制

• 批准号: 10221612
• 负责人: DAVID J. KWIATKOWSKI
• 金额: $ 176.14万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221612
• 关键词: ATP Synthesis Pathway; Acetyl-CoA Carboxylase; Adult; Alleles; Bannayan Syndrome; Biguanides; CRISPR screen; Candidate Disease Gene; Cell division; Cells; ChIP-seq; Defect; Dependence; Development; Disease; Drosophila genus; Epigenetic Process; Event; Fatty Acids; Frequencies; Gene Targeting; Genes; Genetic; Genetic Predisposition to Disease; Genetic Screening; Genetic Transcription; Germ-Line Mutation; Goals; Growth; Hamartoma; Impairment; In Vitro; Individual; Knock-out; Knowledge; Malignant Neoplasms; Mammalian Cell; Metabolic; Modality; Modeling; Molecular; Multiple Hamartoma Syndrome; Mutation; Oncogenic; Oxidative Phosphorylation; Oxygen; Pathogenesis; Pathway interactions; Peutz-Jeghers Syndrome; Play; Principal Investigator; Program Research Project Grants; Purines; Role; Signal Pathway; Signal Transduction; Stress; Syndrome; TSC1 gene; TSC1/2 gene; The Cancer Genome Atlas; Tuberous sclerosis protein complex; Tumor Suppressor Genes; Tumor Suppressor Proteins; United States National Institutes of Health; ascorbate; cancer genetics; cell killing; cytotoxic; efficacy evaluation; gene function; in vivo; inhibitor/antagonist; insight; mTOR Signaling Pathway; new therapeutic target; novel; novel therapeutic intervention; nucleotide metabolism; programs; screening; stem; therapeutic target; transcription factor; tumor

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项目总结/摘要 请参阅每个项目/核心的个别项目摘要/摘要