FASEB's The Endoplasmic Reticulum (ER) Conference: Structure, Function, and Disease

项目总结/摘要 该提案要求提供资金，以支持初级摘要选定和邀请的差旅和住宿费用 研究人员在“内质网会议：结构，功能和疾病”，由 美国实验生物学学会联合会（FASEB）将于2021年6月在 佛蒙特州萨克斯顿河的佛蒙特学院这是一个两年一度的会议，起源于2007年， 传统上是内质网的生物化学、细胞生物学、生理学和病理生理学， 网织膜（ER）。特别是对于2021年，这次会议将特别强调将基本的 ER功能的研究与许多不同疾病的转化/临床研究， 功能障碍-“ER应激”-被牵连。本次会议有三个目标：（1）利用发言人 邀请，程序结构，和会议推广，以统一的基础和转化研究， 内质网（ER），以加速发现广泛的治疗靶点， 其中涉及ER功能障碍-“ER应激”的疾病。(2)促进参与和职业生涯 培养早期职业调查人员和受训人员、妇女和代表性不足群体的成员， 通过有针对性的演讲邀请，明智的抽象选择和丰富的演讲机会， 职业研讨会的重点。和（3），通过邀请，为该领域注入新的视角 向未参加会议的调查人员宣传会议， 过去这些目标将通过PI的规划来促进，PI是 会议在2019年，和Co-I，谁与会议有着悠久的历史，并带来了互补的科学 领导团队的专业知识。提议邀请的发言人出席会议，其中许多人已经 确认的参与，包括研究ER蛋白靶向的基础科学家的强有力代表， 折叠和成熟，ER相关降解，ER应激传感和信号传导，以及通信 ER和其他细胞器以及细胞过程之间的联系。补充这些领域的是类似的 研究代谢性疾病和肥胖症、肾脏疾病、癌症、囊性 纤维化、病原体感染和与ER功能障碍相关的其他疾病。此外，发言者名单将带来 许多新的与会者参加会议，并包括一个干部，是人口多样化，包括 妇女、初级调查员和代表性不足群体的成员人数较多。职业生涯 为选定的摘要举办的发展讲习班和长篇讲座将提供一种额外的机制， 这些群体的知名度。在一个允许从美国境内和从 欧洲，即风景优美，又能满足与会者的家庭需求，并结合针对性 通过传统渠道和社交媒体的推广，我们相信这次会议将吸引强大的 最能促进上述目标的受众。

Project Summary/Abstract This proposal requests funds to support travel and lodging costs for junior abstract-selected and invited investigators at the “Endoplasmic Reticulum Meeting: Structure, Function, and Disease”, sponsored by the Federation of American Societies for Experimental Biology (FASEB) and to be held in June, 2021 at the Vermont Academy in Saxton's River, Vermont. This is a biennial meeting which originated in 2007, the focus of which has traditionally been the biochemistry, cell biology, physiology, and pathophysiology of the endoplasmic reticulum (ER). For 2021 in particular, this meeting will place a particular emphasis on bringing together basic research on ER function with translational/clinical research on the many diverse diseases in which ER dysfunction—“ER stress”—is implicated. There are three objectives to this meeting: (1) Utilize speaker invitations, program structure, and meeting promotion to unite basic and translational research on the endoplasmic reticulum (ER), in order to accelerate the discovery of therapeutic targets for the broad array of diseases in which ER dysfunction—“ER stress”—is implicated. (2) Facilitate the participation and career development of early-career investigators and trainees, women, and members of underrepresented groups, through targeted speaker invitations, judicious abstract selection and plentiful speaking opportunities, and focused career workshop sessions. And (3), inject new perspectives into the field through invitations to speakers new to the meeting and promotion of the meeting to investigators that have not been represented in the past. These objectives will be facilitated by the planning of the PI, who was the junior organizer for the meeting in 2019, and the Co-I, who has a long history with the meeting and brings complementary scientific expertise to the leadership team. The proposed invited speakers to the meeting, many of whom have already confirmed participation, include strong representation among basic scientists studying ER protein targeting, folding, and maturation, ER-associated degradation, ER stress sensing and signaling, and communication between the ER and other organelles and cellular processes. Complementing these areas are a similarly dynamic group of investigators studying metabolic diseases and obesity, kidney disease, cancer, cystic fibrosis, pathogen infection, and other diseases linked to ER dysfunction. Moreover, the speaker list will bring many new attendees to the meeting, and encompasses a cadre that is demographically diverse, including strong representation of women, junior investigators, and members of underrepresented groups. Career development workshops and full-length talks for selected abstracts will allow an additional mechanism to foster the visibility of these groups. In a location that permits easy travel from within the United States and from Europe, that is scenic, and that can accommodate family needs of attendees, and combined with targeted promotion through traditional channels and social media, we believe that this meeting will attract a robust audience that can best foster the objectives listed above.