FASEB's The Endoplasmic Reticulum (ER) Conference: Structure, Function, and Disease

项目摘要/摘要 该提案要求提供资金，以支持被选中和被邀请的青少年的旅费和住宿费 “内质网会议：结构、功能和疾病”的研究人员，由 美国实验生物学学会联合会(FASEB)将于2021年6月在 位于佛蒙特州萨克斯顿河的佛蒙特州学院。这是一次始于2007年的两年一次的会议，重点是 它传统上是内质的生物化学、细胞生物学、生理学和病理生理学 网状结构(ER)。特别是在2021年，本次会议将特别强调将基本的 内质网功能的研究与内质网在多种疾病中的翻译/临床研究 功能障碍--“内质网应激”--也有牵连。这次会议有三个目的：(1)利用演讲者 邀请、计划结构和会议推广，以统一基础研究和翻译研究 内质网(ER)，以加速发现治疗靶点的广泛阵列 内质网功能障碍--“内质网应激”--涉及的疾病。(2)促进参与和职业发展 发展职业生涯早期调查员和实习生、妇女和代表性不足群体的成员， 通过有针对性的演讲邀请、明智的摘要选择和丰富的演讲机会，以及 有重点的职业研讨会。以及(3)，通过邀请 新参加会议的发言者和向尚未派代表参加会议的调查人员宣传会议 过去的事。这些目标将通过国际和平协会的规划而得到促进，国际和平协会是 2019年的会议，以及与会议有着悠久历史并带来互补科学的 向领导团队提供专业知识。提议邀请演讲者参加会议，其中许多人已经 已确认的参与，包括研究ER蛋白靶向的基础科学家中的强烈代表性， 折叠和成熟，内质网相关的降解，内质网应激感应和信号传递，以及沟通 内质网与其他细胞器和细胞过程之间的联系。与这些领域相辅相成的是类似的 研究代谢性疾病和肥胖、肾脏疾病、癌症、囊肿症的动态研究小组 纤维化、病原体感染和其他与内质网功能障碍有关的疾病。此外，演讲者名单将带来 许多新参加会议的人，包括人口统计上不同的干部，包括 妇女、初级调查员和任职人数不足的群体成员的代表人数较多。职业生涯 发展研讨会和选定摘要的全程演讲将允许建立一个额外的机制，以促进 这些团体的可见度。在一个可以方便地从美国境内和从美国 欧洲，即风景秀丽，又能容纳家庭需求的与会者，并有针对性地与之相结合 通过传统渠道和社交媒体进行推广，我们相信这次会议将吸引稳健的 能够最好地促进上述目标的受众。

Project Summary/Abstract This proposal requests funds to support travel and lodging costs for junior abstract-selected and invited investigators at the “Endoplasmic Reticulum Meeting: Structure, Function, and Disease”, sponsored by the Federation of American Societies for Experimental Biology (FASEB) and to be held in June, 2021 at the Vermont Academy in Saxton's River, Vermont. This is a biennial meeting which originated in 2007, the focus of which has traditionally been the biochemistry, cell biology, physiology, and pathophysiology of the endoplasmic reticulum (ER). For 2021 in particular, this meeting will place a particular emphasis on bringing together basic research on ER function with translational/clinical research on the many diverse diseases in which ER dysfunction—“ER stress”—is implicated. There are three objectives to this meeting: (1) Utilize speaker invitations, program structure, and meeting promotion to unite basic and translational research on the endoplasmic reticulum (ER), in order to accelerate the discovery of therapeutic targets for the broad array of diseases in which ER dysfunction—“ER stress”—is implicated. (2) Facilitate the participation and career development of early-career investigators and trainees, women, and members of underrepresented groups, through targeted speaker invitations, judicious abstract selection and plentiful speaking opportunities, and focused career workshop sessions. And (3), inject new perspectives into the field through invitations to speakers new to the meeting and promotion of the meeting to investigators that have not been represented in the past. These objectives will be facilitated by the planning of the PI, who was the junior organizer for the meeting in 2019, and the Co-I, who has a long history with the meeting and brings complementary scientific expertise to the leadership team. The proposed invited speakers to the meeting, many of whom have already confirmed participation, include strong representation among basic scientists studying ER protein targeting, folding, and maturation, ER-associated degradation, ER stress sensing and signaling, and communication between the ER and other organelles and cellular processes. Complementing these areas are a similarly dynamic group of investigators studying metabolic diseases and obesity, kidney disease, cancer, cystic fibrosis, pathogen infection, and other diseases linked to ER dysfunction. Moreover, the speaker list will bring many new attendees to the meeting, and encompasses a cadre that is demographically diverse, including strong representation of women, junior investigators, and members of underrepresented groups. Career development workshops and full-length talks for selected abstracts will allow an additional mechanism to foster the visibility of these groups. In a location that permits easy travel from within the United States and from Europe, that is scenic, and that can accommodate family needs of attendees, and combined with targeted promotion through traditional channels and social media, we believe that this meeting will attract a robust audience that can best foster the objectives listed above.