A Multicomponent Intervention to Increase HIV Risk Perceptions and PrEP Initiation among Black Men Who Have Sex With Men

旨在提高男男性行为黑人的 HIV 风险认知和 PrEP 启动的多成分干预措施

• 批准号: 10223987
• 负责人: Derek Tramel Dangerfield II
• 金额: $ 18.39万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223987
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Age; Appointments and Schedules; Award; Baltimore; Behavior; Behavioral; California; Cessation of life; Cities; Clinical; Communities; Data; Data Collection; Development; Discrimination; Disease susceptibility; Doctor of Philosophy; Educational workshop; Elements; Evaluation; Exposure to; Focus Groups; Fostering; Future; Guidelines; HIV; HIV Infections; HIV Seronegativity; HIV risk; HIV/STD; Health; Health Personnel; Health Promotion; Healthcare; Incidence; Infection; Insurance; Insurance Coverage; Intervention; Judgment; Lead; Life; Life Cycle Stages; Maryland; Medical; Mentors; Mentorship; Methods; Modeling; Opioid; Patients; Perception; Phase; Population; Predisposition; Prevention education; Prevention strategy; Principal Investigator; Procedures; Provider; Public Health Schools; Recording of previous events; Research; Research Methodology; Research Personnel; Research Training; Risk; Risk Behaviors; Role; Sampling; School Nursing; Scientist; Self Efficacy; Services; Sex Behavior; Statistical Data Interpretation; Structure; Techniques; Technology; Telemedicine; Testing; Time; TimeLine; Training; Universities; Work; acceptability and feasibility; base; behavioral/social science; black men who have sex with men; career; cohort; data standards; design; diaries; efficacy trial; experience; generation difference; health belief; health disparity; high risk; implementation science; improved; innovation; interest; medical schools; men who have sex with men; motivational enhancement therapy; multi-component intervention; peer; peer support; pre-exposure prophylaxis; preference; prevent; research and development; risk perception; sexual risk behavior; skills; smartphone Application; social stigma; theories; therapy design; training opportunity; transmission process; uptake; willingness

PROJECT SUMMARY/ABSTRACT Tragically, HIV infections among Black men who have sex with men (BMSM) in the U.S. persist. Despite the availability and interest in pre-exposure prophylaxis (PrEP), effective uptake among BMSM remains low. It is imperative to mitigate barriers to PrEP initiation among this group, which could require HIV interventions that incorporate behavioral, biomedical, and structural strategies. The proposed theory-guided, multi-component intervention is designed to enhance HIV risk perceptions and increase PrEP initiation among BMSM in Baltimore City, using an existing mobile smartphone application along with peer change agents to record and review sexual risk behaviors and encourage PrEP initiation. The proposed research and training plan in this Mentored Research Scientist Developmental Award (K01) proposal will provide the principal investigator, Derek T. Dangerfield II, PhD, with the skills needed in intervention design to develop into a productive, independent investigator. The research and training aims proposed address a critical gap in HIV prevention; it is well established that extant work has failed to substantially lower infections among BMSM throughout the U.S. To strategically advance these training aims, this K01 proposal is crafted to facilitate professional development and research capacities as a rising independent investigator. Targeted course work, didactic workshops, and in-depth mentorship from experts in the domains of clinical intervention design, life course theoretical approaches to health, and statistical analysis are incorporated to facilitate hands-on opportunities to apply newly developed skills. The combined use of technology, peers, and PrEP leverages existing relevant prevention strategies for a multi-component intervention. This research is innovative and timely as it responds to federal and academic calls for carefully considerate, interdisciplinary interventions to reduce HIV incidence among priority populations. The aims of this proposal incorporate qualitative and quantitative research methods to explore the preferences of the components of an intervention to increase PrEP initiation among the population. This research has implications for understanding whether the methods used in this intervention can be applied in clinical settings or can be applied in peer-based settings to circumvent the barriers of traditional healthcare engagement. Dr. Dangerfield will be primarily mentored by senior investigator Jason Farley, PhD, MPH, ANP-BC, FAAN at the Johns Hopkins School of Nursing, with additional mentoring from Drs. Chris Beyrer (Johns Hopkins Bloomberg School of Public Health), Ricky Bluthenthal (University of Southern California Keck School of Medicine), and Renata Arrington-Sanders (Johns Hopkins School of Medicine). Through research and didactic mentoring and training, Dr. Dangerfield will build upon his expertise in behavioral social science to develop a successful career in designing high-impact, multicomponent clinical interventions and reduce health disparities.

项目总结/摘要 不幸的是，美国黑人男性同性性行为（BMSM）中的艾滋病毒感染持续存在。 尽管存在暴露前预防（PrEP），但BMSM中的有效吸收 仍然很低。当务之急是减少这一群体中启动PrEP的障碍，这可能需要艾滋病毒 包括行为、生物医学和结构战略的干预措施。提出的理论指导， 多成分干预旨在提高艾滋病毒风险认知，并增加PrEP的启动， 巴尔的摩市的BMSM，使用现有的移动的智能手机应用程序沿着同伴变更代理， 记录和审查性风险行为，并鼓励PrEP启动。拟议的研究和培训 本指导研究科学家发展奖（K 01）提案中的计划将提供主要 调查员德里克·T Dangerfield II，博士，具有干预设计所需的技能，以发展成为一个 高效独立的调查员拟议的研究和培训目标针对艾滋病毒方面的一个重大差距 预防;众所周知，现存的工作未能大幅降低BMSM之间的感染 为了在战略上推进这些训练目标，K 01建议旨在促进 专业发展和研究能力作为一个新兴的独立调查员。有针对性的课程， 教学研讨会，并在临床干预设计，生活领域的专家深入指导 课程的理论方法，以健康和统计分析被纳入，以促进实践 有机会应用新开发的技能。技术、同行和PrEP的结合使用 现有的多组成部分干预的相关预防战略。这项研究具有创新性， 及时，因为它响应了联邦和学术界对仔细考虑的跨学科干预措施的呼吁， 降低重点人群的艾滋病毒感染率。本提案的目标包括质量和 定量研究方法，探讨干预措施的组成部分的偏好，以增加 在人群中启动PrEP。这项研究对于理解这些方法是否 在这种干预中使用的方法可以应用于临床环境，也可以应用于基于同行的环境， 规避传统医疗保健参与的障碍。丹格菲尔德博士将主要由 高级研究员Jason法利，博士，公共卫生硕士，ANP-BC，FAAN在约翰霍普金斯护理学院， 克里斯·贝勒博士（约翰霍普金斯布隆伯格公共卫生学院）、里奇· Bluthenthal（南加州凯克医学院）和Renata Arrington-Sanders（约翰 霍普金斯医学院）。通过研究和教学指导和培训，Dangerfield博士将建立 凭借他在行为社会科学方面的专业知识，在设计高影响力方面取得了成功， 多方面的临床干预措施，减少健康差距。