Core C Analysis and Modeling --Davenport UNSW

分析和建模核心将通过1)开发最优研究设计和 测量和比较S(H)IV在猕猴体内潜伏期再激活的建模方法 BNAbs或FTY-720；2)开发分析方法以确定SIV重新激活的早期来源和 分析处理中断(ATI)后油层“补种”的量化；3)免疫分析 ATI和反弹过程中的动态和病毒选择；4)协调和整合分析 项目1和2，并向更广泛的研究社区提供数据和分析工具。AMC将是 与所有项目和子项目紧密结合，确保实验和动物研究 设计和实施的目的是最大限度地提高我们分析病毒重新激活的动态和 抗体和细胞在这上面迁移。AMC成员将与项目负责人密切合作，以 制定最佳研究设计，包括采样时间和测序深度等参数 必填项。

The Analysis and Modeling Core will support the Program by 1) developing optimal study design and modeling methods for measuring and comparing S(H)IV reactivation from latency in monkeys treated with bNAbs or FTY-720; 2) developing analytical approaches for identifying early sources of SIV reactivation and quantification of reservoir ‘re-seeding’ following analytical treatment interruption (ATI); 3) analyzing immune dynamics and viral selection during ATI and rebound; and 4) coordinating and integrating analysis between Projects 1 & 2, and providing data and analysis tools to the broader research community. The AMC will be integrated closely within all projects and sub-projects to ensure that the experimental and animal research is designed and conducted to maximize our ability to dissect the dynamics of viral reactivation and the impact of antibodies and cell migration on this. Members of the AMC will work closely with the Project leaders to develop optimal study designs, including parameters such as sampling times and depth of sequencing required.