Microglia and the inflammation spectrum - not just good or bad

小胶质细胞和炎症谱——不仅仅是好还是坏

• 批准号: DP210103469
• 负责人: A/Prof Marco Morsch
• 金额: $ 29.29万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103469
• 关键词: Microglia; inflammation; spectrum; just; good

Cell-mediated tissue clearance following brain injury is a universal mechanism. However, our understanding of the cells that perform these tasks is very limited. Our project will characterise this inflammatory response at a single-cell level using the zebrafish spinal cord as a versatile experimental model. The project is expected to strongly contribute to the molecular understanding of the mechanisms underlying debris removal and will advance innovative technologies that facilitate intellectual progress in neuroscience. It will produce new insights into the process of neuronal degeneration, promote Australia’s growing reputation as a global leader in neuroscience, and provide high quality training for early career researchers.

脑损伤后细胞介导的组织清除是一种普遍的机制。然而，我们对执行这些任务的细胞的了解非常有限。我们的项目将使用斑马鱼脊髓作为通用的实验模型，在单细胞水平上表征这种炎症反应。该项目预计将极大地促进对碎片清除机制的分子理解，并将推动推动神经科学方面的智力进步的创新技术。它将对神经元退化过程产生新的见解，促进澳大利亚作为全球神经科学领先者的声誉日益增长，并为早期职业研究人员提供高质量的培训。