功能获得性 SAMD9 和 SAMD9L 突变的造血后果-猫眼课题宝

功能获得性 SAMD9 和 SAMD9L 突变的造血后果

批准号：

10294460

负责人：

Jason Ross Schwartz

金额：

$5.68万

依托单位：

VANDERBILT UNIVERSITY MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

未结题

起止时间：

2020-11-01 至 2025-01-31

来源：

https://reporter.nih.gov/project-details/10294460

关键词：

ANXA5 gene Addison&apos s disease Alleles Apoptosis Architecture Ataxia Autophagocytosis Bone Marrow Diseases CD34 gene CRISPR/Cas technology Caspase Cell Count Cell Cycle Arrest Cell Line Cell Proliferation Cells Cellular Assay Childhood Chromosome 7 Chromosome Deletion Chromosomes Clinical Clonal Evolution Data Development Dysmyelopoietic Syndromes Genes Genetic Genital system Genomics Germ-Line Mutation Goals Growth Hematologic Neoplasms Hematopoietic Hematopoietic stem cells Hypocellular Bone Marrow In Vitro Infection Interferon-alpha Interferons Lead Lesion Malignant Neoplasms Maps Modeling Molecular Monosomy 7 Mutate Mutation Myelogenous Myeloid Cells Myelopoiesis Neoplasms Outcome Output Pancytopenia Pathologic Pathway interactions Patients Pediatric Hematology Phenotype Proteins Publishing Recovery Reporting Research Support Resolution Sampling Series Somatic Mutation Stains Syndrome Time Uniparental Disomy Variant alanine aminopeptidase clinical phenotype cohort cytotoxic differential expression gain of function gain of function mutation hematopoietic cell transplantation improved in vivo induced pluripotent stem cell insight mutant pressure repaired senescence stem cell model stem cells tool transcriptome sequencing

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会议论文

Hematopoietic consequences of gain-of-function SAMD9 and SAMD9L mutations

批准号：

10363681
项目类别：
资助金额：

$14.87万
财政年份：

2020
负责人：

Jason Ross Schwartz
依托单位：

VANDERBILT UNIVERSITY MEDICAL CENTER

Hematopoietic consequences of gain-of-function SAMD9 and SAMD9L mutations

批准号：

10549853
项目类别：
资助金额：

$14.87万
财政年份：

2020
负责人：

Jason Ross Schwartz
依托单位：

VANDERBILT UNIVERSITY MEDICAL CENTER