COMPREHENSIVE REAGENTS FOR IMMUNOPHENOTYPING RABBIT CELL-MEDIATED IMMUNITY.
COMPREHENSIVE REAGENTS FOR IMMUNOPHENOTYPING RABBIT CELL-MEDIATED IMMUNITY.
用于兔细胞介导免疫免疫表型分析的综合试剂。
批准号：
10291477
负责人：
NATALIE CASTELLANA
金额：
$54.06万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-07-01 至 2022-06-30
关键词：
AntibodiesAntibody RepertoireCD19 geneCD3 AntigensCellsCellular ImmunityCommunicable DiseasesEvaluationGenerationsITGAX geneImmuneImmunophenotypingLlamaMonoclonal AntibodiesMusOryctolagus cuniculusPapillomavirus InfectionsReagentRecombinantsTuberculosisbasehuman modelnanobodiesnew technologyprotein expressionquality assurance
中文摘要
翻译
本提案的目的是产生针对免疫细胞的试剂，包括先天和适应性免疫细胞，以全面分析兔细胞介导的免疫。这是基于需要扩大单克隆抗体（MAb）库，用于人类传染病（如结核病和乳头瘤病毒感染）的兔模型。投标者建议使用两种不同的方法来制造这些抗体，并利用几种新技术来产生可能更有市场的纳米体。
英文摘要
The objective of this proposal is to generate reagents against immune cells including innate and adaptive immune cells, for comprehensive profiling of rabbit cell-mediated immunity. This is based on the need to expand the monoclonal antibody(MAb) repertoire for rabbit models of human infectious diseases such as tuberculosis and papillomavirus infection. The Offeror proposes to use two different approaches to make these Abs and to exploit several novel technologies to generate nanobodies that may be more marketable.
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