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3D Ultra-sensitive Ultrasound Microvessel Imaging for Breast Mass Differentiation

3D 超灵敏超声微血管成像用于乳腺肿块分化

基本信息

批准号：
10282891
负责人：
Ping Gong
金额：
$ 7.95万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10282891
关键词：
3-Dimensional Acoustics Affect American American Cancer Society Anxiety Benign Biological Markers Biopsy Blood Vessels Breast Cancer Etiology Cessation of life Classification Clinical Clinical Research Code Contrast Media Custom Development Diagnosis Diagnostic Doppler Ultrasound Enhancement Technology Ensure Evaluation Favorable Clinical Outcome Goals Gold Image Imaging Techniques Imaging technology Investigation Light Lobe Malignant Neoplasms Mammary Neoplasms Mammography Mass in breast Methods Morphologic artifacts Pathology Patients Penetration Research Scanning Screening for cancer Side Specificity Techniques Technology Testing Three-Dimensional Imaging Tissues Tumor Angiogenesis Tumor Pathology Ultrasonography United States Woman breast cancer diagnosis breast imaging cancer diagnosis cost cost effective detection sensitivity diagnostic accuracy experience imaging modality improved malignant breast neoplasm novel radiologist recruit transmission process tumor two-dimensional

项目摘要

PROJECT SUMMARY Breast cancer, the second-leading cause of cancer deaths among women, affects millions of Americans. Early cancer detection and accurate tumor diagnosis are crucial for favorable clinical outcomes. Ultrasonography (US) is an important imaging modality adjunct to mammography as it is noninvasive, cost-effective, and widely available. However, the low specificity of US limits its diagnosis accuracy, even in combination with mammography. The resultant unnecessary benign biopsies substantially increase patients’ cost and anxiety. Tumor angiogenesis can be used as a valuable biomarker for better breast tumor US differentiation. However, conventional Doppler imaging has insufficient vessel detection sensitivity. We have recently developed a novel 2-dimensional ultra-sensitive ultrasound microvessel imaging (2D-UMI) technology, which demonstrates significantly increased vessel detection sensitivity over conventional Doppler methods without the need of using contrast agents. In our preliminary study, the diagnosis accuracy of combining US with 2D-UMI was improved by 15% compared to using conventional US alone. However, 2D tumor vascularity evaluation may be incomprehensive as most tumors are heterogeneous. In the proposed research, the 2D-UMI technique will be advanced to 3D imaging, and further enhanced to provide a comprehensive tumor vessel investigation to improve breast tumor classification accuracy and reduce unnecessary benign biopsies. In light of clinical need and our recent diagnostic development, this proposal has two specific aims: Specific Aim 1: Develop and enhance the 3D-UMI scanning sequence. We will develop the UMI sequence in 3D imaging using a Verasonics Vantage research scanner. We will apply multiple coded plane wave transmissions to ensure sufficient incident acoustic energy and ultrasound penetration. We will also develop new tissue clutter filters to eliminate the banding side-lobe artifacts caused by strong reflectors in breast imaging. We will then use a custom flow phantom to test and enhance the technology, and pave the way for the clinical study in Aim 2. Specific Aim 2: Conduct a pilot clinical study of 3D-UMI on patients with breast masses. We will study 42 patients with breast tumors to assess the 3D-UMI’s efficacy in improving breast tumor classification. An experienced radiologist will evaluate the results. We will then compare the diagnosis accuracy (using pathology as the gold standard) between the combined diagnosis of conventional US plus 3D-UMI versus use of conventional US alone. Successful completion of the proposed research will lead to a novel ultra-sensitive 3D Doppler technology to facilitate diagnosis of breast tumors with high accuracy.

项目总结