Feasibility of a smartphone based c-peptide lateral flow test for use in home based screening for type 1 diabetes
基于智能手机的 C 肽侧向层析测试用于家庭 1 型糖尿病筛查的可行性
基本信息
- 批准号:10044903
- 负责人:
- 金额:$ 6.37万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Grant for R&D
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The vision of this project is to evaluate a safe and efficient screening system for type 1 diabetes (T1D). Digostics is working with Oxford and Yale universities to incorporate its novel GTT@home product into home-based T1D screening; GTT@home is seen as a major step forward, replacing in-clinic oral glucose tolerance test (OGTT), a major barrier to testing, with a convenient, easy to use home test.Testing for c-peptide (an indicator of insulin production), is another important element of T1D screening; OGTT and c-peptide together provide important clinical information. Oxford University will soon evaluate 2 methods of home sample collection for laboratory c-peptide testing, to be provided with GTT@home. The samples will be mailed to a lab for testing. Potential issues with this approach include the sample collection procedure and the need to mail the samples for laboratory testing, with the associated complexities and risk of sample degradation.The proposed project will evaluate modifying the use of a new lateral flow test device (LFD) for c-peptide that is intended for in-clinic testing. Digostics will replace the in-clinic benchtop LFD reading unit with a smartphone app that can image the LFD test using a smartphone camera, allowing the test data to be collected from home, as happens currently with Digostics' GTT@home OGTT system. Ultimately, the two tests could be read using a modified Digostics smartphone app.With the LFD system modified to enable imaging of the LFD test by smartphone, and with calibration of the test data performed in the Cloud, a method comparison will be undertaken at Swansea University, comparing the LFD point of care system to the LFD smartphone system. If the performance of the smartphone c-peptide system is acceptable in the method comparison, it will be presented to the T1D researchers at Oxford and Yale Universities for review, with a view to scoping a subsequent programme to evaluate home c-peptide LFD testing in combination with GTT@home, with both tests being read by a Digostics mobile app and data sent to the Digostics Cloud for processing. With home LFD testing and the associated use of smartphone apps now proven to be reliable and highly acceptable to users, implementing c-peptide alongside GTT@home should be a straightforward task. Success in this project would present a major step forward in T1D screening, which is constrained by clinic workload and patient accessibility to in-clinic testing.
该项目的愿景是评估1型糖尿病(T1 D)安全有效的筛查系统。Digostics正在与牛津大学和耶鲁大学合作,将其新型GTT@home产品纳入家庭T1 D筛查; GTT@home被视为向前迈出的重要一步,用方便,易于使用的家庭测试取代了临床口服葡萄糖耐量试验(OGTT),这是测试的主要障碍。(胰岛素产生的指标)是T1 D筛查的另一个重要因素; OGTT和C肽一起提供重要的临床信息。牛津大学将很快评估2种用于实验室c肽检测的家庭样本采集方法,将由GTT@home提供。样本将被邮寄到实验室进行测试。这种方法的潜在问题包括样本采集程序和邮寄样本进行实验室检测的需要,以及相关的复杂性和样本降解的风险。拟议项目将评估修改用于临床检测的新型c肽侧流检测装置(LFD)的使用。Digostics将用一个智能手机应用程序取代诊所内的台式LFD阅读单元,该应用程序可以使用智能手机摄像头对LFD测试进行成像,从而允许从家中收集测试数据,就像Digostics的GTT@home OGTT系统目前所做的那样。最终,这两个测试可以使用修改后的Digostics智能手机应用程序进行读取。随着LFD系统的修改,使LFD测试的智能手机成像,并在云中进行测试数据的校准,斯旺西大学将进行方法比较,比较LFD护理点系统与LFD智能手机系统。如果智能手机c肽系统的性能在方法比较中是可接受的,它将被提交给牛津大学和耶鲁大学的T1 D研究人员进行审查,以期确定后续计划的范围,以评估家庭c肽LFD测试与GTT@home的组合,两种测试都由Digostics移动的应用程序读取,数据发送到Digostics Cloud进行处理。随着家庭LFD测试和智能手机应用程序的相关使用现在被证明是可靠的,并且被用户高度接受,将C肽与GTT@home一起实施应该是一项简单的任务。该项目的成功将使T1 D筛查向前迈出重要一步,T1 D筛查受到诊所工作量和患者对诊所内检测的可及性的限制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
- 批准号:
2879865 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
相似海外基金
Impact of Urban Environmental Factors on Momentary Subjective Wellbeing (SWB) using Smartphone-Based Experience Sampling Methods
使用基于智能手机的体验采样方法研究城市环境因素对瞬时主观幸福感 (SWB) 的影响
- 批准号:
2750689 - 财政年份:2025
- 资助金额:
$ 6.37万 - 项目类别:
Studentship
I-Corps: Translation Potential of a Smartphone-Based Crop Disease Detection Application
I-Corps:基于智能手机的农作物病害检测应用程序的翻译潜力
- 批准号:
2403496 - 财政年份:2024
- 资助金额:
$ 6.37万 - 项目类别:
Standard Grant
Development of non-invasive smartphone based navigation system for total hip arthroplasty.
开发基于智能手机的非侵入性全髋关节置换术导航系统。
- 批准号:
23K15709 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Development and evaluation of smartphone application-based education program for improving maternal nutrition in Tanzania
开发和评估基于智能手机应用程序的教育计划,以改善坦桑尼亚孕产妇营养
- 批准号:
23K16471 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Targeting Alcohol-Opioid Co-Use Among Young Adults Using a Novel MHealth Intervention
使用新型 MHealth 干预措施针对年轻人中酒精与阿片类药物的同时使用
- 批准号:
10456380 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别:
iKinnect Mobile Technology to Reduce Teen Substance Misuse and Health Disparities
iKinnect 移动技术可减少青少年药物滥用和健康差异
- 批准号:
10545162 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别:
DS-ARC: A Remote Digital Cognitive Assessment for Down Syndrome-Associated Alzheimer's Disease
DS-ARC:针对唐氏综合症相关阿尔茨海默病的远程数字认知评估
- 批准号:
10638314 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别:
Dynamic Neural Computations Underlying Cognitive Control in Bulimia Nervosa
神经性贪食症认知控制下的动态神经计算
- 批准号:
10638708 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别:
Development of an mHealth Behavioral Sleep Medicine Intervention for use during Medication Assisted Treatment for Opioid Use Disorder
开发用于阿片类药物使用障碍药物辅助治疗的 mHealth 行为睡眠医学干预措施
- 批准号:
10681901 - 财政年份:2023
- 资助金额:
$ 6.37万 - 项目类别: