Systems Biology Approach to SARS-CoV-2 Infection in Individuals with known COVID-19 Contacts: A Prospective Cohort Study
Systems Biology Approach to SARS-CoV-2 Infection in Individuals with known COVID-19 Contacts: A Prospective Cohort Study
批准号:
10287089
负责人:
Nicholas Scanlon
金额:
$10.89万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-07 至 2022-08-31
关键词:
2019-nCoVAntibodiesAntibody ResponseAntibody titer measurementAwardB-LymphocytesBindingBioinformaticsBiological AssayBiometryBloodCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 diagnosisCOVID-19 severityCellsCellular biologyClinicClinicalClinical ResearchCohort StudiesCollaborationsData AnalysesDiagnostic ProcedureDiseaseEducational workshopEnrollmentEnzyme-Linked Immunosorbent AssayEvaluationFingersFlow CytometryFoundationsFundingGenesGoalsHealth PersonnelHelper-Inducer T-LymphocyteHomeHouseholdHumanImmuneImmune responseImmune systemImmunoglobulin GImmunoglobulin MImmunologic MarkersImmunologicsImmunologyIndividualInfectionKnowledgeLaboratoriesLaboratory ResearchLightMemoryMemory B-LymphocyteMentorsMethodsMolecularNatural ImmunityPatientsPopulationPositioning AttributeProspective cohort studyPublic Health SchoolsResearchResearch ProposalsResearch TrainingResidenciesRiskSARS-CoV-2 antibodySARS-CoV-2 infectionSARS-CoV-2 positiveSamplingScientistSerologySeveritiesSeverity of illnessStructureSymptomsSystemSystems BiologyTechniquesTechnologyTestingTimeTrainingTranslational ResearchUnited States National Institutes of HealthUniversitiesVaccinesViral Load resultVisitWorkWorkplaceadaptive immune responseadaptive immunityarmasymptomatic COVID-19careercohortcytokinedesigndifferential expressionexperiencehigh riskinnovationinsightneutralizing antibodyoutcome predictionpandemic diseasepredictive markerrapid testingresponsesingle-cell RNA sequencingskillssymptomatic COVID-19therapeutic vaccinetraining opportunitytranscriptometranscriptome sequencingvaccinology
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
With this K38 Mentored Stimulating Access to Research in Residency Transition Scholar (StARRTS) award, I
will develop the necessary skills to become an independently funded clinician-scientist, working at the
intersection of immunology, systems biology, and vaccinology. My longstanding commitment to translational
and clinical research provides me with the foundation for this work. During this Award, I will be mentored by Dr.
Nadine Rouphael, an expert in translational immunology, who is interim director of the Hope Clinic, the clinical
arm of the Emory Vaccine Center, Dr. Bali Pulendran, an expert in systems biology at Stanford University, Dr.
Erin Scherer, an expert in B-cell biology and director of the Hope Clinic Vaccine and Treatment Evaluation Unit
(VTEU) Research Laboratory, and Dr. Christina Mehta, an expert in applied biostatistics in the Department of
Biostatistics and Bioinformatics at the Rollins School of Public Health of Emory University. I will have hands on
clinical research and biostatistical training as well as training in laboratory methods related to systems biology,
and will attend workshops in the field. Currently, I am enrolling subjects for my R38 research year and using the
combined diagnostic methods of anti-SARS-CoV-2 IgM/IgG testing and symptom-driven SARS-CoV-2 PCR
testing to better identify individuals with asymptomatic and mild COVID-19. We hypothesize that a systems
biology approach will identify specific baseline immunologic signatures, which predict COVID-19 disease
acquisition and severity and that mild and asymptomatic COVID-19 will be characterized by a specific innate and
adaptive immune responses. We propose a cohort study to complete the following aims: 1) To identify baseline
immunologic markers predictive of COVID-19 disease acquisition and severity, and 2) To characterize the innate
and adaptive immune responses to SARS-CoV-2 in individuals with asymptomatic and mildly symptomatic
COVID-19. Completion of these aims will provide a better understanding of COVID-19 and position me to
transition to independence as a clinician-scientist.
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