Function of RELMβ in oral tolerance breakdown in food allergy

RELMβ 在食物过敏口服耐受破坏中的作用

基本信息

  • 批准号:
    10301157
  • 负责人:
  • 金额:
    $ 19.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-06-09 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT: Research: Food allergy is a potentially life-threatening health condition that affects an increasing proportion of individuals in the US alone. Current daily management of patients with food allergies is limited by the unavailability of reliable biomarkers to accurately predict onset, severity and resolution of disease, and by the lack of curative treatments to replace strict avoidance of the culprit food. A deeper understanding of additional mechanisms - other than IgE - acting in food allergy pathogenesis will be key in filling these gaps. This proposal details a five-year plan to provide Dr. Crestani with the training and expertise to evaluate the role of RELMb as a novel biomarker and molecular player in food allergy building and expanding on strong preliminary observations both in a murine model of food allergy and in food allergic children. The comprehensive evaluation of the role of RELMb in food allergy holds the promise of identifying strongly needed biomarker(s) of disease and possible targets for therapeutic interventions which will be the focus of future longitudinal investigations and may significantly impact the daily care and quality of life of food allergic patients. Candidate: Dr. Crestani long-term goal is to become an independent, NIH-funded investigator focused on disease mechanisms and biomarkers of food allergy, with the goal of improving the currently suboptimal care of food-allergic individuals. There is an urgent and unmet need for novel biomarkers and therapeutic approaches in food allergies. To achieve this goal, her short-term objectives are to obtain further training in biostatistics, data analysis, laboratory techniques, as well as practical skills in cohort building and management. This will be accomplished with formal classes, collaborative work, attendance at conferences, and guidance from established mentors/scientific advisors with relevant expertise. This will result in a unique combination of practical skills and scientific knowledge that will successfully position her for an R01 application and an independent career as a physician-scientist in the field of food allergy. Environment: Dr. Crestani will be mentored by Dr. Chatila (Primary Mentor), a leader investigator in mechanisms of food allergy and head of a fully NIH-funded laboratory, and Dr. Phipatanakul (Co-Mentor), an expert in epidemiology, human cohorts, and clinical investigation in asthma and allergic diseases. Dr. Crestani has assembled an extraordinary team of advisors, including Drs. Lynda Schneider, Kari Nadeau and Rima Kaddurah-Daouk, who have committed their time, resources, and expertise to facilitate Dr. Crestani’s career development and successful completion of the proposed project. During this award period, Dr. Crestani will obtain a Master of Public Health in Clinical Effectiveness through the Harvard School of Public Health (HSPH), and complete additional complementary coursework. The academic environment created by the mentors, institution, and Harvard community at large will provide the ideal milieu for learning and research implementation that will guarantee Dr. Crestani transition into a highly successful independent investigator.
项目摘要/摘要: 研究:食物过敏是一种潜在威胁生命的健康状况,影响到越来越多的 仅在美国就有个人。目前对食物过敏患者的日常管理受到 无法获得可靠的生物标记物来准确预测疾病的发病、严重程度和消退,以及 缺乏根治疗法来替代,严格避免罪魁祸首的饮食。更深入地了解其他 除了免疫球蛋白E以外,作用于食物过敏发病机制的机制将是填补这些空白的关键。这项建议 详细说明了一项五年计划,为克雷斯塔尼博士提供培训和专业知识,以评估RELMb作为 一种新的生物标志物和分子参与者在食物过敏中的建立和扩展 在食物过敏的小鼠模型和食物过敏儿童中的观察。综合评价 RELMb在食物过敏中的作用的研究有望识别疾病急需的生物标记物(S) 和可能的治疗干预目标,这将是未来纵向调查和 可能会显著影响食物过敏患者的日常护理和生活质量。 候选人:克雷斯塔尼博士的长期目标是成为一名独立的、由NIH资助的研究人员,专注于 食物过敏的疾病机制和生物标记物,目的是改善目前不太理想的食物过敏治疗 对食物过敏的人。对新的生物标志物和治疗方法的迫切需求和未得到满足的需求 在食物过敏方面。为了实现这一目标,她的短期目标是获得生物统计学、数据方面的进一步培训 分析、实验室技术,以及队列建设和管理方面的实用技能。这将是 完成正式课程,协作工作,出席会议,并从建立的指导 具有相关专业知识的导师/科学顾问。这将产生一个独特的实践技能和 科学知识,将成功地定位她的R01申请和独立的职业生涯作为 内科医生--食物过敏领域的科学家。 环境:克雷斯塔尼博士将由Chatila博士(主要导师)指导,他是 食物过敏机制和NIH全额资助实验室的负责人,以及Phipatanakul博士(共同导师), 在哮喘和过敏性疾病方面的流行病学、人类队列和临床研究方面的专家。克雷斯塔尼博士 组建了一支非凡的顾问团队,包括Lynda Schneider博士、Kari Nadeau博士和Rima博士 Kaddurah-Daouk,他们投入了时间、资源和专业知识来促进克雷斯塔尼博士的职业生涯 开发并成功完成拟议的项目。在此颁奖期间,克雷斯塔尼博士将 通过哈佛大学公共卫生学院(HSPH)获得临床有效性公共卫生硕士学位, 并完成额外的补充课程作业。导师们营造的学术环境, 机构和整个哈佛社区将为学习和研究的实施提供理想的环境 这将保证克雷斯塔尼博士转变为一名非常成功的独立调查员。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Elena Crestani其他文献

Elena Crestani的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Elena Crestani', 18)}}的其他基金

Function of RELMβ in oral tolerance breakdown in food allergy
RELMβ 在食物过敏口服耐受破坏中的作用
  • 批准号:
    10424584
  • 财政年份:
    2021
  • 资助金额:
    $ 19.49万
  • 项目类别:
Function of RELMβ in oral tolerance breakdown in food allergy
RELMβ 在食物过敏口服耐受破坏中的作用
  • 批准号:
    10621812
  • 财政年份:
    2021
  • 资助金额:
    $ 19.49万
  • 项目类别:

相似海外基金

Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
  • 批准号:
    495182
  • 财政年份:
    2023
  • 资助金额:
    $ 19.49万
  • 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
  • 批准号:
    2601817
  • 财政年份:
    2021
  • 资助金额:
    $ 19.49万
  • 项目类别:
    Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
  • 批准号:
    2029039
  • 财政年份:
    2020
  • 资助金额:
    $ 19.49万
  • 项目类别:
    Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
  • 批准号:
    9888417
  • 财政年份:
    2019
  • 资助金额:
    $ 19.49万
  • 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
  • 批准号:
    17K11318
  • 财政年份:
    2017
  • 资助金额:
    $ 19.49万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9320090
  • 财政年份:
    2017
  • 资助金额:
    $ 19.49万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    10166936
  • 财政年份:
    2017
  • 资助金额:
    $ 19.49万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9761593
  • 财政年份:
    2017
  • 资助金额:
    $ 19.49万
  • 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
  • 批准号:
    BB/M50306X/1
  • 财政年份:
    2014
  • 资助金额:
    $ 19.49万
  • 项目类别:
    Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
  • 批准号:
    288272
  • 财政年份:
    2013
  • 资助金额:
    $ 19.49万
  • 项目类别:
    Miscellaneous Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了