Multi-feature, Multi-scale Atlas

多特征、多尺度图集

• 批准号: 10302203
• 负责人: Paul S Katz
• 金额: $ 26.37万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10302203
• 关键词: Address; Adolescent; Adult; Anatomy; Animal Model; Animals; Atlases; BRAIN initiative; Biological Models; Brain; Cells; Censuses; Complex; Data; Data Science Core; Development; Electrons; Fantasy; Gene Expression; Gene Expression Profile; Genes; Genomics; Goals; Human; Imaging technology; Individual; Interneurons; Mammals; Maps; Modeling; Modernization; Nature; Nervous System Physiology; Nervous system structure; Neuroanatomy; Neurons; Neurosciences; Olfactory Pathways; Organ; Organism; Pathway interactions; Peripheral; Peripheral Nervous System; Standard Model; Synapses; System; Testing; Vision; Visual; Visual system structure; base; cell type; computerized tools; connectome; data access; insight; juvenile animal; large datasets; member; multisensory; nudibranch; relating to nervous system; somatosensory; tool; transcriptome sequencing; web interface

SUMMARY / ABSTRACT – Project 1. Multi-feature, Multi-scale Atlas Project 1 of the Berghia Brain Project is to create a multi-scale, multi-feature atlas of the Berghia brain and peripheral neural plexus. Berghia has a brain that is both physically small enough to be serially sectioned and reconstructed from electron micrographs and also has few enough neurons that they can be individually characterized and catalogued. Developing the tools for this undertaking will aid in the long term goal of the BRAIN Initiative to fully map the human brain. The Berghia brain atlas will contain the connectivity, neuroanatomy, and gene expression profile of individual neurons in the brain. It will also feature how those central neurons connect to neurons in periphery and to end organs. The peripheral plexus itself will be characterized and mapped. This will aid in understanding how a brain and a distributed periphery interact. The atlas will be used to trace out the somatosensory, olfactory, and visual systems to test fundamental models of how these systems are organized. This project will determine whether somatotopic maps are present in the brain. It will also determine how an olfactory system is organized without glomeruli. Finally, it will examine the distributed, multi-sensory nature of vision.

摘要/摘要--项目1.多专题、多比例地图集 贝吉亚大脑项目的第一个项目是创建一个多尺度、多特征的贝吉亚大脑和 周围神经丛。伯吉亚的大脑既小到可以连续切片，又有 从电子显微镜照片重建的，也有足够少的神经元，它们可以单独 刻画并编目的。为这项事业开发工具将有助于实现 大脑倡议，以全面绘制人类大脑的地图。伯吉亚大脑地图集将包含连接， 神经解剖学，以及大脑中单个神经元的基因表达谱。它还将展示那些 中枢神经元与周围的神经元相连，也与末梢器官相连。外周神经丛本身将是 描述并绘制了地图。这将有助于理解大脑和分布的外围设备是如何相互作用的。这个 阿特拉斯将被用来追踪体感、嗅觉和视觉系统，以测试 这些系统是如何组织的。这个项目将确定躯体定位图是否出现在 大脑。它还将决定嗅觉系统是如何在没有肾小球的情况下组织起来的。最后，它将检查 视觉的分布式、多感官特性。