Administrative Core

项目总结/摘要 饮酒在艾滋病病毒携带者中很常见，在艾滋病的风险和管理中发挥着越来越重要的作用。 HIV相关合并症。不健康的饮酒会加剧两个高度流行的艾滋病毒相关的 合并症/并存疾病、慢性疼痛和身体活动不足，这些反过来又会加重酒精中毒 使用和影响PLWH的身体和精神功能。我们建议波士顿酒精研究 艾滋病毒/艾滋病合作-科摩罗中心（波士顿艾滋病中心），作为我们波士顿艾滋病中心的延伸。 酒精研究合作艾滋病毒/艾滋病（ESTA）队列于2011年启动，并于2016年更新， 由NIAAA资助。在波士顿，我们在随机试验中针对这两个可改变的条件，疼痛， 和缺乏身体活动，这对各种其他艾滋病毒相关的合并症有重要影响。我们还将 支持对现有波士顿队列的二次分析，并为以下人员提供支持和指导： 学员和研究人员访问队列。行政核心将负责日常工作， 管理波士顿航空公司及其组成部分的运作。除行政 核心，波士顿研究和临床试验委员会的要素包括两个研究项目组成部分（临床试验）， 生物统计和数据管理核心，领导我们的二次分析和培训任务。具体 行政核心的目标是：1）为波士顿大学提供丰富的研究环境 调查人员和受训人员，并确保高质量的酒精和艾滋病毒的共同感染/共同感染的有效进展， 发生条件科学; 2）集中支持研究项目组成部分临床试验的实施 (e.g.数据安全监测、数字化临床试验招募和入组、生态瞬时 评估，酒精生物标志物测试），超出了个别独立项目所能实现的范围; 3） 促进波士顿队列数据分析的二次数据分析、数据共享和发布 与疼痛、身体活动不足以及身心健康功能有关; 4）提供资源和指导 对于有兴趣从事酒精和艾滋病毒研究的早期职业调查人员; 5）参与合作 科学在波士顿大学的内外。行政核心，以其科学和 行政领导和协调活动，将是必不可少的，以确保波士顿 实现其减少酒精和艾滋病毒相关合并症的目标。

PROJECT SUMMARY/ABSTRACT Alcohol use, common among PLWH, plays an increasingly important role in the risk for and management of HIV-associated comorbidities. Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in PLWH. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of our Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) cohort launched in 2011 and renewed in 2016 with funding from NIAAA. In Boston ARCH CC we target in randomized trials these two modifiable conditions, pain and physical inactivity, that have a critical impact on a variety of other HIV-related comorbidities. We will also support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort. The Administrative Core will be responsible for the day-to-day management of the Boston ARCH CC and the operation of its components. In addition to the Administrative Core, Boston ARCH CC elements include two Research Project Components (clinical trials), and a Biostatistics and Data Management Core that leads our secondary analysis and training missions. The specific aims of the Administrative Core are to: 1) Provide a rich research environment for Boston ARCH CC investigators and trainees, and assure efficient progress of high-quality alcohol and HIV comorbidity/co- occurring condition science; 2) Centralize support for Research Project Component clinical trial implementation (e.g. Data Safety Monitoring, digital clinical trial recruitment and enrollment, ecological momentary assessments, alcohol biomarker tests), beyond what would be achievable by individual stand-alone projects; 3) Facilitate secondary data analysis, data sharing, and publication from analyses of Boston ARCH cohort data related to pain, physical inactivity, and physical and mental health function; 4) Offer resources and mentoring for early career investigators interested in engaging in alcohol and HIV research; 5) Engage in collaborative science within and beyond the Boston ARCH CC. The Administrative Core, with its scientific and administrative leadership and coordinated activities, will be essential for assuring that Boston ARCH CC achieves its goals to reduce alcohol and HIV-associated comorbidities.