Administrative Core

项目摘要/摘要 饮酒在PLWH中很常见，在患高血压的风险和管理中发挥着越来越重要的作用 与艾滋病毒相关的合并症。不健康的饮酒会加剧两种与艾滋病毒相关的高度流行 共病/共病、慢性疼痛和缺乏体力活动，这反过来又会加剧酒精 使用和影响PLWH的生理和心理功能。我们建议波士顿酒精研究中心 关于艾滋病毒/艾滋病-共病中心的合作(波士顿ARCH CC)是我们波士顿中心的延伸 关于艾滋病毒/艾滋病的酒精研究合作(ARCH)队列于2011年启动，并于2016年续签， 资金来自NIAAA。在波士顿ARCH CC中，我们在随机试验中针对这两种可修改的情况，疼痛 以及缺乏体力活动，这对其他各种与艾滋病毒有关的合并症具有严重影响。我们还将 支持对现有波士顿ARCH队列的二次分析，并提供支持和指导 受训人员和调查人员进入队列。行政核心将负责日常工作 管理波士顿拱形CC及其部件的运行。除行政部门外 核心，波士顿ARCH CC要素包括两个研究项目组成部分(临床试验)和一个 生物统计和数据管理核心，领导我们的二级分析和培训任务。具体的 管理核心的目标是：1)为波士顿ARCH CC提供丰富的研究环境 调查人员和受训人员，并确保高质量酒精和艾滋病毒共病/共病的有效进展 发生条件科学；2)集中支持研究项目组成部分临床试验实施 (例如数据安全监测、数字临床试验招募和招募、生态瞬间 评估、酒精生物标记物测试)，超出了单个独立项目所能实现的目标；3) 促进波士顿ARCH队列数据分析的二次数据分析、数据共享和发布 与疼痛、缺乏运动以及身心健康功能有关；4)提供资源和指导 对于有兴趣从事酒精和艾滋病毒研究的早期职业调查人员；5)参与合作 波士顿拱门CC内外的科学。行政核心，具有科学性和科学性 行政领导和协调活动，将是确保波士顿ARCH CC 实现了减少酒精和艾滋病毒相关共病的目标。

PROJECT SUMMARY/ABSTRACT Alcohol use, common among PLWH, plays an increasingly important role in the risk for and management of HIV-associated comorbidities. Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in PLWH. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of our Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) cohort launched in 2011 and renewed in 2016 with funding from NIAAA. In Boston ARCH CC we target in randomized trials these two modifiable conditions, pain and physical inactivity, that have a critical impact on a variety of other HIV-related comorbidities. We will also support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort. The Administrative Core will be responsible for the day-to-day management of the Boston ARCH CC and the operation of its components. In addition to the Administrative Core, Boston ARCH CC elements include two Research Project Components (clinical trials), and a Biostatistics and Data Management Core that leads our secondary analysis and training missions. The specific aims of the Administrative Core are to: 1) Provide a rich research environment for Boston ARCH CC investigators and trainees, and assure efficient progress of high-quality alcohol and HIV comorbidity/co- occurring condition science; 2) Centralize support for Research Project Component clinical trial implementation (e.g. Data Safety Monitoring, digital clinical trial recruitment and enrollment, ecological momentary assessments, alcohol biomarker tests), beyond what would be achievable by individual stand-alone projects; 3) Facilitate secondary data analysis, data sharing, and publication from analyses of Boston ARCH cohort data related to pain, physical inactivity, and physical and mental health function; 4) Offer resources and mentoring for early career investigators interested in engaging in alcohol and HIV research; 5) Engage in collaborative science within and beyond the Boston ARCH CC. The Administrative Core, with its scientific and administrative leadership and coordinated activities, will be essential for assuring that Boston ARCH CC achieves its goals to reduce alcohol and HIV-associated comorbidities.