Secondary Analyses of Clinical Trial Data to Understand Factors Associated with Alcohol Use Among Alaska Native Populations

对临床试验数据进行二次分析，以了解与阿拉斯加原住民饮酒相关的因素

• 批准号: 10315800
• 负责人: Maria Christina Crouch
• 金额: $ 7.1万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-14 至 2024-07-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10315800
• 关键词: Address; Alaska Native; Alcohol abuse; Alcohol consumption; Alcohols; American Indians; Applications Grants; Area; Attention; Awareness; Belief; Cardiac health; Cardiovascular Diseases; Cessation of life; Clinical Trials; Communities; Data; Data Set; Death Rate; Development; Diabetes Mellitus; Diet; Ethics; Exercise; Fellowship; Future; Goals; Health; Health Services Accessibility; Health behavior; Healthcare; Healthy Eating; Heart; Holistic Health; Injury; Institutional Racism; Intervention; Investigation; Knowledge; Literature; Liver diseases; Logistic Regressions; Mental Health; Mental disorders; Methodology; Modeling; Morbidity - disease rate; Naltrexone; National Institute on Alcohol Abuse and Alcoholism; Native-Born; Nature; Outcome; Pain; Participant; Personal Satisfaction; Physical activity; Population; Post-Traumatic Stress Disorders; Prevalence; Public Health; Publications; Quality of life; Randomized; Recording of previous events; Recovery; Research; Research Personnel; Risk; Risk Behaviors; Role; Sampling; Sertraline; Severities; Smoker; Smoking; Smoking and Health Research; Stereotyping; Stigmatization; Survival Analysis; Textiles; Tobacco; Tobacco Use Cessation; Tobacco smoke; Training; Trauma; Treatment outcome; United States National Institutes of Health; Writing; alcohol abuse therapy; alcohol effect; alcohol intervention; alcohol related consequences; alcohol research; alcohol use disorder; alcohol-related injury; binge drinking; cardiovascular health; career; clinical trial analysis; control trial; design; drinking; exhaustion; experience; health disparity; improved; intervention effect; medication compliance; modifiable risk; non-Native; nutrition; physical conditioning; physical inactivity; premature; protective factors; resilience; secondary analysis; skills; social stigma; traumatic stress; treatment effect; treatment planning; treatment research; treatment trial

Project Summary/Abstract This project proposal reflects a collaborative and coordinated training and research plan that will facilitate the applicant’s transition towards becoming an independent alcohol researcher within Alaska Native (AN) communities. Namely, four training goals are proposed: 1) Develop expertise in alcohol treatment and clinical trials research within the AN population; 2) Obtain proficiency in traumatic stress research and the impact of trauma on alcohol use among AN people; 3) Acquire methodological and advanced quantitative skills for designing and analyzing clinical trials; and 4) Further develop scientific writing skills, strengthen publication record, and grow professionally as an AN alcohol researcher and future leader in the field. These skills will be applied to carrying out the proposed project of examining two randomized control trial datasets related to alcohol use disorder (AUD), problematic drinking, smoking, trauma, culture, and quality of life (QOL). Clinical trials data will be from (1) the Naltrexone Study39, a clinical trial of naltrexone and sertraline for the treatment of AUD among an AN and non-Native sample; and (2) the HEALTHH Study42, a clinical trial for people who smoke tobacco that includes two interventions to promote heart health (a) tobacco cessation and physical activity and (b) medication adherence and a heart healthy AN diet. Research examining AN representation in clinical trials for major mental disorders between 1986 and 2005 found that not one of the 10,000 participants were from American Indian (AI) or AN heritage5. Moreover, an exhaustive literature search in 2014 of AI/AN mental health treatment intervention resulted in only two clinical trials. This is more than troublesome given the fact that AN people experience disproportionately high rates of AUD, problematic drinking, alcohol-related injury and death, smoking, health disparities, high rates of PTSD and traumatic stress, and systemic racism and oppression2,5,12,16,25,48. These factors impact the very fabric of AN culture, wellbeing, and alcohol treatment access, utilization, and outcomes8,13,23. Thus, this project will explore the extent to which trauma, smoking, and culture impacts drinking and QOL outcomes. Aim 1 is to examine predictors of alcohol use and moderators of naltrexone treatment effects among AN people using data from the Naltrexone Study and Aim 2 is to examine the impact of drinking on the efficacy of two culturally tailored interventions targeting modifiable risks for cardiovascular health and the effects of these intervention on drinking among AN people using data from The HEALTHH Study. Resultant data from these aims have the potential to identify the nature and impacts of factors associated with alcohol use, treatment, and outcomes among AN people, which is of great public health importance. Additionally, the results have implications for developing trauma-informed, culturally derived, multilevel alcohol treatment interventions for AN people.

项目总结/文摘