Secondary Analyses of Clinical Trial Data to Understand Factors Associated with Alcohol Use Among Alaska Native Populations

对临床试验数据进行二次分析，以了解与阿拉斯加原住民饮酒相关的因素

• 批准号: 10315800
• 负责人: Maria Christina Crouch
• 金额: $ 7.1万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-14 至 2024-07-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10315800
• 关键词: Address; Alaska Native; Alcohol abuse; Alcohol consumption; Alcohols; American Indians; Applications Grants; Area; Attention; Awareness; Belief; Cardiac health; Cardiovascular Diseases; Cessation of life; Clinical Trials; Communities; Data; Data Set; Death Rate; Development; Diabetes Mellitus; Diet; Ethics; Exercise; Fellowship; Future; Goals; Health; Health Services Accessibility; Health behavior; Healthcare; Healthy Eating; Heart; Holistic Health; Injury; Institutional Racism; Intervention; Investigation; Knowledge; Literature; Liver diseases; Logistic Regressions; Mental Health; Mental disorders; Methodology; Modeling; Morbidity - disease rate; Naltrexone; National Institute on Alcohol Abuse and Alcoholism; Native-Born; Nature; Outcome; Pain; Participant; Personal Satisfaction; Physical activity; Population; Post-Traumatic Stress Disorders; Prevalence; Public Health; Publications; Quality of life; Randomized; Recording of previous events; Recovery; Research; Research Personnel; Risk; Risk Behaviors; Role; Sampling; Sertraline; Severities; Smoker; Smoking; Smoking and Health Research; Stereotyping; Stigmatization; Survival Analysis; Textiles; Tobacco; Tobacco Use Cessation; Tobacco smoke; Training; Trauma; Treatment outcome; United States National Institutes of Health; Writing; alcohol abuse therapy; alcohol effect; alcohol intervention; alcohol related consequences; alcohol research; alcohol use disorder; alcohol-related injury; binge drinking; cardiovascular health; career; clinical trial analysis; control trial; design; drinking; exhaustion; experience; health disparity; improved; intervention effect; medication compliance; modifiable risk; non-Native; nutrition; physical conditioning; physical inactivity; premature; protective factors; resilience; secondary analysis; skills; social stigma; traumatic stress; treatment effect; treatment planning; treatment research; treatment trial

Project Summary/Abstract This project proposal reflects a collaborative and coordinated training and research plan that will facilitate the applicant’s transition towards becoming an independent alcohol researcher within Alaska Native (AN) communities. Namely, four training goals are proposed: 1) Develop expertise in alcohol treatment and clinical trials research within the AN population; 2) Obtain proficiency in traumatic stress research and the impact of trauma on alcohol use among AN people; 3) Acquire methodological and advanced quantitative skills for designing and analyzing clinical trials; and 4) Further develop scientific writing skills, strengthen publication record, and grow professionally as an AN alcohol researcher and future leader in the field. These skills will be applied to carrying out the proposed project of examining two randomized control trial datasets related to alcohol use disorder (AUD), problematic drinking, smoking, trauma, culture, and quality of life (QOL). Clinical trials data will be from (1) the Naltrexone Study39, a clinical trial of naltrexone and sertraline for the treatment of AUD among an AN and non-Native sample; and (2) the HEALTHH Study42, a clinical trial for people who smoke tobacco that includes two interventions to promote heart health (a) tobacco cessation and physical activity and (b) medication adherence and a heart healthy AN diet. Research examining AN representation in clinical trials for major mental disorders between 1986 and 2005 found that not one of the 10,000 participants were from American Indian (AI) or AN heritage5. Moreover, an exhaustive literature search in 2014 of AI/AN mental health treatment intervention resulted in only two clinical trials. This is more than troublesome given the fact that AN people experience disproportionately high rates of AUD, problematic drinking, alcohol-related injury and death, smoking, health disparities, high rates of PTSD and traumatic stress, and systemic racism and oppression2,5,12,16,25,48. These factors impact the very fabric of AN culture, wellbeing, and alcohol treatment access, utilization, and outcomes8,13,23. Thus, this project will explore the extent to which trauma, smoking, and culture impacts drinking and QOL outcomes. Aim 1 is to examine predictors of alcohol use and moderators of naltrexone treatment effects among AN people using data from the Naltrexone Study and Aim 2 is to examine the impact of drinking on the efficacy of two culturally tailored interventions targeting modifiable risks for cardiovascular health and the effects of these intervention on drinking among AN people using data from The HEALTHH Study. Resultant data from these aims have the potential to identify the nature and impacts of factors associated with alcohol use, treatment, and outcomes among AN people, which is of great public health importance. Additionally, the results have implications for developing trauma-informed, culturally derived, multilevel alcohol treatment interventions for AN people.

项目摘要/摘要 该项目建议反映了一项协作和协调的培训和研究计划，这将有助于 申请人过渡到成为阿拉斯加本地人（AN）的独立酒精研究人员 社区。即提出了四​​个培训目标：1）在酒精治疗和临床方面发展专业知识 AN人群中的试验研究； 2）熟练掌握创伤性压力研究和 人们对饮酒的创伤； 3）获得方法论和高级定量技能 设计和分析临床试验； 4）进一步发展科学写作技巧，增强出版 记录并成为该领域的酒精研究人员和未来领导者的专业成长。这些技能将是 应用于进行拟议的项目，以检查两个随机对照试验数据集 酒精使用障碍（AUD），有问题的饮酒，吸烟，创伤，文化和生活质量（QOL）。临床 试验数据将来自（1）Naltrexone study39，Naltrexone研究，这是Naltrexone和Serialline的临床试验，用于处理 在AN和非本地样本中aud; （2）Healthh研究42，这是一项针对那些人的临床试验 烟烟草包括两种促进心脏健康的干预措施（a）烟草戒烟和身体 活性和（b）药物依从性和心脏健康的饮食。研究研究 1986年至2005年之间主要精神障碍的临床试验发现，10,000名参与者中没有一个 来自美洲印第安人（AI）或遗产5。此外，AI/AN的详尽文献搜索 心理健康治疗干预措施仅导致两项临床试验。鉴于 人们经历的声音，饮酒率有问题，与酒精有关的事实不成比例 受伤和死亡，吸烟，健康差异，PTSD和创伤性压力高的率以及全身种族主义 和观点2,5,12,16,25,48。这些因素会影响文化，福祉和酒精治疗的结构 访问，利用和结果8,13,23。那个项目将探讨创伤，吸烟和 文化会影响饮酒和质量结果。目的1是检查酒精使用和主持人的预测指标 使用Naltrexone研究和AIM 2的数据，纳曲酮治疗的效果是检查 饮酒对两种文化量身定制干预措施的有效性的影响，针对可改变的风险 心血管健康以及这些干预对饮酒的影响 Healthh研究。这些目标的结果数据有可能确定的性质和影响 与饮酒，治疗和结果相关的因素，这是很棒的公共卫生 重要性。此外，结果对开发创伤的，文化的衍生，有影响 人民的多级酒精治疗干预措施。