Therapeutic interventions for post-stroke rehabilitation

中风后康复的治疗干预

• 批准号: 10314765
• 负责人: Helen M Bramlett
• 金额: --
• 依托单位: MIAMI VA HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-01 至 2025-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10314765
• 关键词: Acute; Adoptive Transfer; Affect; Animal Model; Body Weight decreased; Brain; Brain hemorrhage; Caring; Cause of Death; Cerebral Ischemia; Clinic; Clinical; Clinical Trials; Cognition; Cognitive; Communication; Communities; Data; Deterioration; Exercise; Fatigue; Female; Fingerprint; Frequencies; Future; Gait speed; Genes; Goals; Hippocampus (Brain); Home; Hormones; Human; Impaired cognition; Infarction; Inflammation; Inflammatory; Intervention; Ischemic Brain Injury; Ischemic Stroke; Laboratories; Laboratory Animals; Link; Mechanics; Mediating; Middle Cerebral Artery Occlusion; Mitochondria; Modeling; Monitor; Muscle; Neurons; Outcome; Patients; Physical Exercise; Physical activity; Physiological; Pilot Projects; Play; Proteomics; Quality of life; Rattus; Recovery; Research; Role; Serum; Skeleton; Stroke; Stroke prevention; Temperature; Testing; Therapeutic; Therapeutic Effect; Therapeutic Intervention; Tissues; Transient Ischemic Attack; Translating; Treatment Efficacy; United States Department of Veterans Affairs; Vesicle; Veterans; Veterans Health Administration; aged; base; behavioral study; cost; cytokine; disability; efficacy testing; extracellular vesicles; frailty; glucose metabolism; hormone therapy; improved; in vivo; indexing; insight; middle age; mitochondrial dysfunction; mortality; motor deficit; motor learning; natural hypothermia; neurobehavior; neuroinflammation; neuronal survival; novel; novel therapeutic intervention; out-of-hospital cardiac arrest; post stroke; post stroke cognitive impairment; preclinical study; response; sex; spinal cord and brain injury; stroke model; stroke outcome; stroke patient; stroke rehabilitation; stroke risk; stroke survivor; thrombolysis; transcriptional reprogramming; transcriptomics; translational goal; vibration

Stroke remains one of the leading causes of death and disability in the USA. The principal objective of the current proposal is to test the efficacy of combined therapeutic hypothermia with whole body vibration on post-stroke cognitive improvement using a model of stroke in aged rats. There are three main types of stroke: transient ischemic attack, hemorrhagic stroke and acute ischemic stroke, with the latter constituting 87% of total stroke cases. Currently, the only clinical therapies available for acute ischemic stroke are thrombolysis (tPA) and mechanical endovascular recanalization, both of which have only limited applications in a small number of patients. Cognitive decline is one of the most significant problems affecting almost two-thirds of stroke survivors for up to 6 years post-stroke. Therefore, identifying novel neuroprotective strategies to improve post-stroke cognition remains a high priority. In animal models of stroke (transient middle cerebral artery occlusion – tMCAO), behavioral studies yield evidence of deficits in spatial, non-spatial, and motor learning. These deficits can be minimized in middle-aged rat models of stroke with noninvasive whole body vibration (WBV) therapy. Likewise, long-standing research from our laboratory shows that therapeutic hypothermia (TH) is a potent neuroprotective therapy in experimental cerebral ischemia with multiple effects at several stages of the ischemic cascade. The translational goal of our successful study will be to identify a novel therapeutic approach for stroke rehabilitation that can be moved quickly to testing in clinical trials.

中风仍然是美国死亡和残疾的主要原因之一。的主要目标 目前的建议是测试联合治疗低温与全身振动的疗效， 使用老年大鼠中风模型的中风后认知改善。主要有三类 中风：短暂性脑缺血发作、出血性中风和急性缺血性中风，后者构成 87%的中风病例。目前，可用于急性缺血性卒中的唯一临床疗法是 血栓溶解（tPA）和机械血管内再通，两者都只有有限的 应用于少数患者。认知能力下降是最重要的问题之一 影响了近三分之二的中风幸存者长达6年的中风后。因此，识别新 改善中风后认知的神经保护策略仍然是高度优先的。的动物模型中 中风（短暂性大脑中动脉闭塞- tMCAO），行为研究提供了缺陷的证据 在空间、非空间和运动学习方面。这些缺陷可以在中年大鼠模型中最小化 非侵入性全身振动（WBV）治疗中风。同样，长期的研究 我们实验室的研究表明，治疗性低温（TH）是一种有效的神经保护疗法， 实验性脑缺血在缺血级联反应的几个阶段具有多重影响。的 我们成功研究的一个转化目标将是确定一种新的治疗中风的方法 康复可以迅速转移到临床试验中进行测试。